diff --git a/packages/python/security/pycryptodome/package.mk b/packages/python/security/pycryptodome/package.mk
index 9968250abe..ed656eeee7 100644
--- a/packages/python/security/pycryptodome/package.mk
+++ b/packages/python/security/pycryptodome/package.mk
@@ -7,24 +7,21 @@ PKG_SHA256="35019dff66c25db80d0c739b9c7b59bb0f61551897681c6dbdbdd0f7198f780f"
 PKG_LICENSE="BSD"
 PKG_SITE="https://pypi.org/project/pycryptodome"
 PKG_URL="https://github.com/Legrandin/${PKG_NAME}/archive/v${PKG_VERSION}.tar.gz"
-PKG_DEPENDS_TARGET="toolchain Python3 distutilscross:host"
+PKG_DEPENDS_TARGET="toolchain Python3"
 PKG_LONGDESC="PyCryptodome is a self-contained Python package of low-level cryptographic primitives."
 PKG_TOOLCHAIN="manual"
 
 pre_configure_target() {
   cd ${PKG_BUILD}
   rm -rf .${TARGET_NAME}
-
-  export PYTHONXCPREFIX="${SYSROOT_PREFIX}/usr"
-  export LDSHARED="${CC} -shared"
 }
 
 make_target() {
-  python3 setup.py build --cross-compile
+  python_target_env python3 setup.py build
 }
 
 makeinstall_target() {
-  python3 setup.py install --root=${INSTALL} --prefix=/usr
+  exec_thread_safe python_target_env python3 setup.py install --root=${INSTALL} --prefix=/usr
 
   # Remove SelfTest bloat
   find ${INSTALL} -type d -name SelfTest -exec rm -fr "{}" \; 2>/dev/null || true