diff --git a/packages/addons/addon-depends/rpi-tools-depends/lg-gpio/package.mk b/packages/addons/addon-depends/rpi-tools-depends/lg-gpio/package.mk
index 3d1ed533c2..9c533d66ba 100644
--- a/packages/addons/addon-depends/rpi-tools-depends/lg-gpio/package.mk
+++ b/packages/addons/addon-depends/rpi-tools-depends/lg-gpio/package.mk
@@ -7,7 +7,7 @@ PKG_SHA256="b08d8569d6dc8fa91a42ba1e37f620fdcb19d6bf2330e4b7d7301431ddbe124c"
 PKG_LICENSE="Unlicense"
 PKG_SITE="http://abyz.me.uk/lg/"
 PKG_URL="https://github.com/joan2937/lg/archive/v${PKG_VERSION}.tar.gz"
-PKG_DEPENDS_TARGET="toolchain Python3 swig:host"
+PKG_DEPENDS_TARGET="toolchain Python3 swig:host setuptools:host"
 PKG_LONGDESC="A library for Linux Single Board Computers (SBC) which allows control of the General Purpose Input Outputs (GPIO)"
 PKG_TOOLCHAIN="manual"
 
@@ -21,6 +21,6 @@ make_target() {
   (
     cd PY_LGPIO
     swig -python lgpio.i
-    python_target_env python setup.py build
+    python_target_env python3 -m build -n -w -x
   )
 }
diff --git a/packages/addons/addon-depends/system-tools-depends/i2c-tools/package.mk b/packages/addons/addon-depends/system-tools-depends/i2c-tools/package.mk
index daf6199b59..be4a517f2b 100644
--- a/packages/addons/addon-depends/system-tools-depends/i2c-tools/package.mk
+++ b/packages/addons/addon-depends/system-tools-depends/i2c-tools/package.mk
@@ -7,7 +7,7 @@ PKG_SHA256="1f899e43603184fac32f34d72498fc737952dbc9c97a8dd9467fadfdf4600cf9"
 PKG_LICENSE="GPL"
 PKG_SITE="https://i2c.wiki.kernel.org/index.php/I2C_Tools"
 PKG_URL="https://www.kernel.org/pub/software/utils/i2c-tools/${PKG_NAME}-${PKG_VERSION}.tar.xz"
-PKG_DEPENDS_TARGET="toolchain Python3"
+PKG_DEPENDS_TARGET="toolchain Python3 setuptools:host"
 PKG_LONGDESC="A heterogeneous set of I2C tools for Linux."
 PKG_BUILD_FLAGS="-sysroot"
 
@@ -20,7 +20,7 @@ make_target() {
 
   (
     cd py-smbus
-    python_target_env python3 setup.py build
+    python_target_env python3 -m build -n -w -x
   )
 }
 
@@ -31,6 +31,6 @@ makeinstall_target() {
         install
   (
     cd py-smbus
-    exec_thread_safe python_target_env python3 setup.py install --root=${INSTALL} --prefix=/usr
+    python3 -m installer --overwrite-existing dist/*.whl -d ${INSTALL} -p /usr
   )
 }
diff --git a/packages/python/devel/Jinja2/package.mk b/packages/python/devel/Jinja2/package.mk
index 1ae9fff438..f2f1c953fc 100644
--- a/packages/python/devel/Jinja2/package.mk
+++ b/packages/python/devel/Jinja2/package.mk
@@ -9,9 +9,4 @@ PKG_SITE="https://pypi.org/project/Jinja2/"
 PKG_URL="https://files.pythonhosted.org/packages/source/${PKG_NAME:0:1}/${PKG_NAME}/${PKG_NAME,,}-${PKG_VERSION}.tar.gz"
 PKG_DEPENDS_HOST="Python3:host setuptools:host MarkupSafe:host"
 PKG_LONGDESC="Jinja is a fast, expressive, extensible templating engine."
-PKG_TOOLCHAIN="manual"
-
-makeinstall_host() {
-  export DONT_BUILD_LEGACY_PYC=1
-  exec_thread_safe python3 setup.py install --prefix=${TOOLCHAIN}
-}
+PKG_TOOLCHAIN="python"
diff --git a/packages/python/devel/Jinja2/patches/0001-revert-setuptools-removal.patch b/packages/python/devel/Jinja2/patches/0001-revert-setuptools-removal.patch
deleted file mode 100644
index 06be73f67a..0000000000
--- a/packages/python/devel/Jinja2/patches/0001-revert-setuptools-removal.patch
+++ /dev/null
@@ -1,116 +0,0 @@
-From 24f91e001d3b7b7037b2fb572a633f3a7fa7ca1c Mon Sep 17 00:00:00 2001
-From: Rudi Heitbaum <rudi@heitbaum.com>
-Date: Wed, 17 Jul 2024 11:19:20 +0000
-Subject: [PATCH] revert setuptools removal
-
----
- setup.cfg | 81 +++++++++++++++++++++++++++++++++++++++++++++++++++++++
- setup.py  |  8 ++++++
- 2 files changed, 89 insertions(+)
- create mode 100644 setup.cfg
- create mode 100644 setup.py
-
-diff --git a/setup.cfg b/setup.cfg
-new file mode 100644
-index 0000000..b4531db
---- /dev/null
-+++ b/setup.cfg
-@@ -0,0 +1,81 @@
-+[metadata]
-+name = Jinja2
-+version = attr: jinja2.__version__
-+url = https://palletsprojects.com/p/jinja/
-+project_urls =
-+    Donate = https://palletsprojects.com/donate
-+    Documentation = https://jinja.palletsprojects.com/
-+    Changes = https://jinja.palletsprojects.com/changes/
-+    Source Code = https://github.com/pallets/jinja/
-+    Issue Tracker = https://github.com/pallets/jinja/issues/
-+    Chat = https://discord.gg/pallets
-+license = BSD-3-Clause
-+license_files = LICENSE.rst
-+maintainer = Pallets
-+maintainer_email = contact@palletsprojects.com
-+description = A very fast and expressive template engine.
-+long_description = file: README.rst
-+long_description_content_type = text/x-rst
-+classifiers =
-+    Development Status :: 5 - Production/Stable
-+    Environment :: Web Environment
-+    Intended Audience :: Developers
-+    License :: OSI Approved :: BSD License
-+    Operating System :: OS Independent
-+    Programming Language :: Python
-+    Topic :: Internet :: WWW/HTTP :: Dynamic Content
-+    Topic :: Text Processing :: Markup :: HTML
-+
-+[options]
-+packages = find:
-+package_dir = = src
-+include_package_data = True
-+python_requires = >= 3.7
-+# Dependencies are in setup.py for GitHub's dependency graph.
-+
-+[options.packages.find]
-+where = src
-+
-+[options.entry_points]
-+babel.extractors =
-+    jinja2 = jinja2.ext:babel_extract[i18n]
-+
-+[tool:pytest]
-+testpaths = tests
-+filterwarnings =
-+    error
-+
-+[coverage:run]
-+branch = True
-+source =
-+    jinja2
-+    tests
-+
-+[coverage:paths]
-+source =
-+    src
-+    */site-packages
-+
-+[mypy]
-+files = src/jinja2
-+python_version = 3.7
-+show_error_codes = True
-+disallow_subclassing_any = True
-+disallow_untyped_calls = True
-+disallow_untyped_defs = True
-+disallow_incomplete_defs = True
-+no_implicit_optional = True
-+local_partial_types = True
-+no_implicit_reexport = True
-+strict_equality = True
-+warn_redundant_casts = True
-+warn_unused_configs = True
-+warn_unused_ignores = True
-+warn_return_any = True
-+warn_unreachable = True
-+
-+[mypy-jinja2.defaults]
-+no_implicit_reexport = False
-+
-+[mypy-markupsafe]
-+no_implicit_reexport = False
-diff --git a/setup.py b/setup.py
-new file mode 100644
-index 0000000..79d0708
---- /dev/null
-+++ b/setup.py
-@@ -0,0 +1,8 @@
-+from setuptools import setup
-+
-+# Metadata goes in setup.cfg. These are here for GitHub's dependency graph.
-+setup(
-+    name="Jinja2",
-+    install_requires=["MarkupSafe>=2.0"],
-+    extras_require={"i18n": ["Babel>=2.7"]},
-+)
--- 
-2.43.0
-
diff --git a/packages/python/devel/Mako/package.mk b/packages/python/devel/Mako/package.mk
index 80e7fb98d6..f99520bbce 100644
--- a/packages/python/devel/Mako/package.mk
+++ b/packages/python/devel/Mako/package.mk
@@ -10,9 +10,4 @@ PKG_SITE="https://pypi.org/project/Mako"
 PKG_URL="https://files.pythonhosted.org/packages/source/${PKG_NAME:0:1}/${PKG_NAME}/${PKG_NAME}-${PKG_VERSION}.tar.gz"
 PKG_DEPENDS_HOST="Python3:host setuptools:host MarkupSafe:host"
 PKG_LONGDESC="Mako is a super-fast templating language that borrows the best ideas from the existing templating languages."
-PKG_TOOLCHAIN="manual"
-
-makeinstall_host() {
-  export DONT_BUILD_LEGACY_PYC=1
-  exec_thread_safe python3 setup.py install --prefix=${TOOLCHAIN}
-}
+PKG_TOOLCHAIN="python"
diff --git a/packages/python/devel/MarkupSafe/package.mk b/packages/python/devel/MarkupSafe/package.mk
index 66a06a9df2..e11cc64e6f 100644
--- a/packages/python/devel/MarkupSafe/package.mk
+++ b/packages/python/devel/MarkupSafe/package.mk
@@ -10,9 +10,4 @@ PKG_SITE="https://pypi.org/project/MarkupSafe/"
 PKG_URL="https://files.pythonhosted.org/packages/source/${PKG_NAME:0:1}/${PKG_NAME}/${PKG_NAME}-${PKG_VERSION}.tar.gz"
 PKG_DEPENDS_HOST="Python3:host setuptools:host"
 PKG_LONGDESC="MarkupSafe implements a XML/HTML/XHTML Markup safe string for Python"
-PKG_TOOLCHAIN="manual"
-
-makeinstall_host() {
-  export DONT_BUILD_LEGACY_PYC=1
-  exec_thread_safe python3 setup.py install --prefix=${TOOLCHAIN}
-}
+PKG_TOOLCHAIN="python"
diff --git a/packages/python/devel/flit/package.mk b/packages/python/devel/flit/package.mk
new file mode 100644
index 0000000000..726ecf3550
--- /dev/null
+++ b/packages/python/devel/flit/package.mk
@@ -0,0 +1,22 @@
+# SPDX-License-Identifier: GPL-2.0
+# Copyright (C) 2024-present Team LibreELEC (https://libreelec.tv)
+
+PKG_NAME="flit"
+PKG_VERSION="3.9.0"
+PKG_SHA256="72ad266176c4a3fcfab5f2930d76896059851240570ce9a98733b658cb786eba"
+PKG_LICENSE="BSD"
+PKG_SITE="https://pypi.org/project/flit-core/"
+PKG_URL="https://files.pythonhosted.org/packages/source/f/flit_core/flit_core-${PKG_VERSION}.tar.gz"
+PKG_SOURCE_DIR="flit_core-${PKG_VERSION}"
+PKG_DEPENDS_HOST="Python3:host"
+PKG_LONGDESC="flit provides a PEP 517 build backend for packages using Flit."
+PKG_TOOLCHAIN="manual"
+
+make_host() {
+  export DONT_BUILD_LEGACY_PYC=1
+  python3 -m flit_core.wheel
+}
+
+makeinstall_host() {
+  exec_thread_safe python3 -m bootstrap_install dist/*.whl --installdir=${TOOLCHAIN}/lib/${PKG_PYTHON_VERSION}/site-packages
+}
diff --git a/packages/python/devel/meson/package.mk b/packages/python/devel/meson/package.mk
index 1e1ec1f8fd..33ab09fe10 100644
--- a/packages/python/devel/meson/package.mk
+++ b/packages/python/devel/meson/package.mk
@@ -9,16 +9,9 @@ PKG_SITE="https://mesonbuild.com"
 PKG_URL="https://github.com/mesonbuild/meson/releases/download/${PKG_VERSION}/${PKG_NAME}-${PKG_VERSION}.tar.gz"
 PKG_DEPENDS_HOST="Python3:host setuptools:host"
 PKG_LONGDESC="High productivity build system"
-PKG_TOOLCHAIN="manual"
-
-makeinstall_host() {
-  export DONT_BUILD_LEGACY_PYC=1
-  python3 setup.py build
-}
-
-makeinstall_host() {
-  exec_thread_safe python3 setup.py install --prefix=${TOOLCHAIN} --skip-build
+PKG_TOOLCHAIN="python"
 
+post_makeinstall_target() {
   # Avoid using full path to python3 that may exceed 128 byte limit.
   # Instead use PATH as we know our toolchain is first.
   sed -e '1 s/^#!.*$/#!\/usr\/bin\/env python3/' -i ${TOOLCHAIN}/bin/meson
diff --git a/packages/python/devel/pybuild/package.mk b/packages/python/devel/pybuild/package.mk
new file mode 100644
index 0000000000..6783c4c679
--- /dev/null
+++ b/packages/python/devel/pybuild/package.mk
@@ -0,0 +1,13 @@
+# SPDX-License-Identifier: GPL-2.0
+# Copyright (C) 2024-present Team LibreELEC (https://libreelec.tv)
+
+PKG_NAME="pybuild"
+PKG_VERSION="1.2.1"
+PKG_SHA256="526263f4870c26f26c433545579475377b2b7588b6f1eac76a001e873ae3e19d"
+PKG_LICENSE="BSD"
+PKG_SITE="https://pypi.org/project/build/"
+PKG_URL="https://files.pythonhosted.org/packages/source/b/build/build-${PKG_VERSION}.tar.gz"
+PKG_SOURCE_DIR="build-${PKG_VERSION}"
+PKG_DEPENDS_HOST="flit:host pyproject-hooks:host pyinstaller:host pypackaging:host"
+PKG_LONGDESC="A simple, correct Python build frontend."
+PKG_TOOLCHAIN="python-flit"
diff --git a/packages/python/devel/pycparser/package.mk b/packages/python/devel/pycparser/package.mk
index 45e757101c..b3ea0be6b2 100644
--- a/packages/python/devel/pycparser/package.mk
+++ b/packages/python/devel/pycparser/package.mk
@@ -9,9 +9,4 @@ PKG_SITE="https://pypi.org/project/pycparser/"
 PKG_URL="https://files.pythonhosted.org/packages/source/${PKG_NAME:0:1}/${PKG_NAME}/${PKG_NAME}-${PKG_VERSION}.tar.gz"
 PKG_DEPENDS_HOST="Python3:host setuptools:host"
 PKG_LONGDESC="Complete C99 parser in pure Python"
-PKG_TOOLCHAIN="manual"
-
-makeinstall_host() {
-  export DONT_BUILD_LEGACY_PYC=1
-  exec_thread_safe python3 setup.py install --prefix="${TOOLCHAIN}"
-}
+PKG_TOOLCHAIN="python"
diff --git a/packages/python/devel/pyelftools/package.mk b/packages/python/devel/pyelftools/package.mk
index 0cbb817091..139abca524 100644
--- a/packages/python/devel/pyelftools/package.mk
+++ b/packages/python/devel/pyelftools/package.mk
@@ -9,8 +9,4 @@ PKG_SITE="https://github.com/eliben/pyelftools"
 PKG_URL="https://github.com/eliben/pyelftools/archive/refs/tags/v${PKG_VERSION}.tar.gz"
 PKG_DEPENDS_HOST="Python3:host setuptools:host"
 PKG_LONGDESC="Library for analyzing ELF files and DWARF debugging information"
-PKG_TOOLCHAIN="manual"
-
-makeinstall_host() {
-  exec_thread_safe python3 setup.py install --prefix=${TOOLCHAIN}
-}
+PKG_TOOLCHAIN="python"
diff --git a/packages/python/devel/pyinstaller/package.mk b/packages/python/devel/pyinstaller/package.mk
new file mode 100644
index 0000000000..94f4334126
--- /dev/null
+++ b/packages/python/devel/pyinstaller/package.mk
@@ -0,0 +1,18 @@
+# SPDX-License-Identifier: GPL-2.0
+# Copyright (C) 2024-present Team LibreELEC (https://libreelec.tv)
+
+PKG_NAME="pyinstaller"
+PKG_VERSION="0.7.0"
+PKG_SHA256="a26d3e3116289bb08216e0d0f7d925fcef0b0194eedfa0c944bcaaa106c4b631"
+PKG_LICENSE="MIT"
+PKG_SITE="https://pypi.org/project/installer/"
+PKG_URL="https://files.pythonhosted.org/packages/source/i/installer/installer-${PKG_VERSION}.tar.gz"
+PKG_SOURCE_DIR="installer-${PKG_VERSION}"
+PKG_DEPENDS_HOST="flit:host"
+PKG_LONGDESC="installer provides basic functionality and abstractions for handling wheels and installing packages from wheels."
+PKG_TOOLCHAIN="python-flit"
+
+makeinstall_host() {
+  # simple bootstrap install, but should be able to call itself if needed
+  unzip -o -d ${TOOLCHAIN}/lib/${PKG_PYTHON_VERSION}/site-packages dist/*.whl
+}
diff --git a/packages/python/devel/pyinstaller/patches/0001-Add-overwrite-existing-option-that-overwrites-existi.patch b/packages/python/devel/pyinstaller/patches/0001-Add-overwrite-existing-option-that-overwrites-existi.patch
new file mode 100644
index 0000000000..145d8687f2
--- /dev/null
+++ b/packages/python/devel/pyinstaller/patches/0001-Add-overwrite-existing-option-that-overwrites-existi.patch
@@ -0,0 +1,82 @@
+From 4628ef70e1159d3cbab58d395f647c3dff887650 Mon Sep 17 00:00:00 2001
+From: Carl Smedstad <carl.smedstad@protonmail.com>
+Date: Tue, 13 Feb 2024 21:10:22 +0100
+Subject: [PATCH] Add --overwrite-existing option that overwrites existing
+ files
+
+Implement the --overwrite-existing option that, if supplied, will make
+installer overwrite any already existing package files instead of
+failing. With this flag, installer can be used in an idempotent manner,
+i.e. the same command can be executed multiple times with the same
+result:
+
+    python -m installer --overwrite-existing --destdir=tmp dist/*.whl
+    python -m installer --overwrite-existing --destdir=tmp dist/*.whl
+    python -m installer --overwrite-existing --destdir=tmp dist/*.whl
+---
+ src/installer/__main__.py     |  6 ++++++
+ src/installer/destinations.py |  5 ++++-
+ tests/test_destinations.py    | 22 ++++++++++++++++++++++
+ 3 files changed, 32 insertions(+), 1 deletion(-)
+
+diff --git a/src/installer/__main__.py b/src/installer/__main__.py
+index 7ece8d213fe4..b587232912f9 100644
+--- a/src/installer/__main__.py
++++ b/src/installer/__main__.py
+@@ -51,6 +51,11 @@ def _get_main_parser() -> argparse.ArgumentParser:
+         choices=["all", "entries", "none"],
+         help="validate the wheel against certain part of its record (default=none)",
+     )
++    parser.add_argument(
++        "--overwrite-existing",
++        action="store_true",
++        help="silently overwrite existing files",
++    )
+     return parser
+ 
+ 
+@@ -95,6 +100,7 @@ def _main(cli_args: Sequence[str], program: Optional[str] = None) -> None:
+             script_kind=get_launcher_kind(),
+             bytecode_optimization_levels=bytecode_levels,
+             destdir=args.destdir,
++            overwrite_existing=args.overwrite_existing,
+         )
+         installer.install(source, destination, {})
+ 
+diff --git a/src/installer/destinations.py b/src/installer/destinations.py
+index 31a254c387be..982e6adfc218 100644
+--- a/src/installer/destinations.py
++++ b/src/installer/destinations.py
+@@ -111,6 +111,7 @@ class SchemeDictionaryDestination(WheelDestination):
+         hash_algorithm: str = "sha256",
+         bytecode_optimization_levels: Collection[int] = (),
+         destdir: Optional[str] = None,
++        overwrite_existing: bool = False,
+     ) -> None:
+         """Construct a ``SchemeDictionaryDestination`` object.
+ 
+@@ -127,6 +128,7 @@ class SchemeDictionaryDestination(WheelDestination):
+         :param destdir: A staging directory in which to write all files. This
+             is expected to be the filesystem root at runtime, so embedded paths
+             will be written as though this was the root.
++        :param overwrite_existing: silently overwrite existing files.
+         """
+         self.scheme_dict = scheme_dict
+         self.interpreter = interpreter
+@@ -134,6 +136,7 @@ class SchemeDictionaryDestination(WheelDestination):
+         self.hash_algorithm = hash_algorithm
+         self.bytecode_optimization_levels = bytecode_optimization_levels
+         self.destdir = destdir
++        self.overwrite_existing = overwrite_existing
+ 
+     def _path_with_destdir(self, scheme: Scheme, path: str) -> str:
+         file = os.path.join(self.scheme_dict[scheme], path)
+@@ -161,7 +164,7 @@ class SchemeDictionaryDestination(WheelDestination):
+         - Hashes the written content, to determine the entry in the ``RECORD`` file.
+         """
+         target_path = self._path_with_destdir(scheme, path)
+-        if os.path.exists(target_path):
++        if not self.overwrite_existing and os.path.exists(target_path):
+             message = f"File already exists: {target_path}"
+             raise FileExistsError(message)
+ 
diff --git a/packages/python/devel/pypackaging/package.mk b/packages/python/devel/pypackaging/package.mk
new file mode 100644
index 0000000000..ac48d7327d
--- /dev/null
+++ b/packages/python/devel/pypackaging/package.mk
@@ -0,0 +1,13 @@
+# SPDX-License-Identifier: GPL-2.0
+# Copyright (C) 2024-present Team LibreELEC (https://libreelec.tv)
+
+PKG_NAME="pypackaging"
+PKG_VERSION="24.1"
+PKG_SHA256="026ed72c8ed3fcce5bf8950572258698927fd1dbda10a5e981cdf0ac37f4f002"
+PKG_LICENSE="BSD"
+PKG_SITE="https://pypi.org/project/build/"
+PKG_URL="https://files.pythonhosted.org/packages/source/p/packaging/packaging-${PKG_VERSION}.tar.gz"
+PKG_SOURCE_DIR="packaging-${PKG_VERSION}"
+PKG_DEPENDS_HOST="flit:host pyinstaller:host"
+PKG_LONGDESC="Reusable core utilities for various Python Packaging interoperability specifications."
+PKG_TOOLCHAIN="python-flit"
diff --git a/packages/python/devel/pyproject-hooks/package.mk b/packages/python/devel/pyproject-hooks/package.mk
new file mode 100644
index 0000000000..02d8696834
--- /dev/null
+++ b/packages/python/devel/pyproject-hooks/package.mk
@@ -0,0 +1,13 @@
+# SPDX-License-Identifier: GPL-2.0
+# Copyright (C) 2024-present Team LibreELEC (https://libreelec.tv)
+
+PKG_NAME="pyproject-hooks"
+PKG_VERSION="1.0.0"
+PKG_SHA256="f271b298b97f5955d53fb12b72c1fb1948c22c1a6b70b315c54cedaca0264ef5"
+PKG_LICENSE="BSD"
+PKG_SITE="https://pypi.org/project/pyproject-hooks/"
+PKG_URL="https://files.pythonhosted.org/packages/source/p/pyproject_hooks/pyproject_hooks-${PKG_VERSION}.tar.gz"
+PKG_SOURCE_DIR="pyproject_hooks-${PKG_VERSION}"
+PKG_DEPENDS_HOST="flit:host pyinstaller:host"
+PKG_LONGDESC="pyproject-hooks provides the basic functionality to help write tooling that generates distribution files from Python projects."
+PKG_TOOLCHAIN="python-flit"
diff --git a/packages/python/devel/pyyaml/package.mk b/packages/python/devel/pyyaml/package.mk
index 6141591ded..7bd3c2b4bd 100644
--- a/packages/python/devel/pyyaml/package.mk
+++ b/packages/python/devel/pyyaml/package.mk
@@ -9,9 +9,4 @@ PKG_SITE="https://pypi.org/project/PyYAML/"
 PKG_URL="https://files.pythonhosted.org/packages/source/${PKG_NAME:0:1}/${PKG_NAME}/${PKG_NAME}-${PKG_VERSION}.tar.gz"
 PKG_DEPENDS_HOST="Python3:host setuptools:host"
 PKG_LONGDESC="YAML parser and emitter for Python"
-PKG_TOOLCHAIN="manual"
-
-makeinstall_host() {
-  export DONT_BUILD_LEGACY_PYC=1
-  exec_thread_safe python3 setup.py install --prefix="${TOOLCHAIN}"
-}
+PKG_TOOLCHAIN="python"
diff --git a/packages/python/devel/setuptools/package.mk b/packages/python/devel/setuptools/package.mk
index f91679b31c..edb9bd04b4 100644
--- a/packages/python/devel/setuptools/package.mk
+++ b/packages/python/devel/setuptools/package.mk
@@ -3,19 +3,11 @@
 # Copyright (C) 2018-present Team LibreELEC (https://libreelec.tv)
 
 PKG_NAME="setuptools"
-PKG_VERSION="52.0.0"
-PKG_SHA256="ff0c74d1b905a224d647f99c6135eacbec2620219992186b81aa20012bc7f882"
+PKG_VERSION="73.0.1"
+PKG_SHA256="d59a3e788ab7e012ab2c4baed1b376da6366883ee20d7a5fc426816e3d7b1193"
 PKG_LICENSE="OSS"
 PKG_SITE="https://pypi.org/project/setuptools"
-PKG_URL="https://github.com/pypa/setuptools/archive/v${PKG_VERSION}.tar.gz"
-PKG_DEPENDS_HOST="Python3:host"
+PKG_URL="https://files.pythonhosted.org/packages/source/${PKG_NAME:0:1}/${PKG_NAME}/${PKG_NAME,,}-${PKG_VERSION}.tar.gz"
+PKG_DEPENDS_HOST="pybuild:host"
 PKG_LONGDESC="Replaces Setuptools as the standard method for working with Python module distributions."
-PKG_TOOLCHAIN="manual"
-
-make_host() {
-  python3 bootstrap.py
-}
-
-makeinstall_host() {
-  exec_thread_safe python3 setup.py install --prefix=${TOOLCHAIN}
-}
+PKG_TOOLCHAIN="python"
diff --git a/packages/python/graphics/Pillow/package.mk b/packages/python/graphics/Pillow/package.mk
index e40f324ddd..7f8f2ac8b3 100644
--- a/packages/python/graphics/Pillow/package.mk
+++ b/packages/python/graphics/Pillow/package.mk
@@ -10,15 +10,9 @@ PKG_SITE="https://python-pillow.org/"
 PKG_URL="https://github.com/python-pillow/${PKG_NAME}/archive/${PKG_VERSION}.tar.gz"
 PKG_DEPENDS_TARGET="toolchain Python3 zlib freetype libjpeg-turbo tiff"
 PKG_LONGDESC="The Python Imaging Library adds image processing capabilities to your Python interpreter."
-PKG_TOOLCHAIN="manual"
+PKG_TOOLCHAIN="python"
 
-make_target() {
-  python_target_env python3 setup.py build_ext --disable-platform-guessing build
-}
-
-makeinstall_target() {
-  exec_thread_safe python_target_env python3 setup.py build_ext --disable-platform-guessing install --root=${INSTALL} --prefix=/usr
-}
+PKG_PYTHON_OPTS_TARGET="-C--build-option=build_ext -C--build-option=--disable-platform-guessing"
 
 post_makeinstall_target() {
   python_remove_source
diff --git a/packages/python/graphics/Pillow/patches/Pillow-0002-Revert-Move-build-config-from-setup.cfg-to-pyproject.patch b/packages/python/graphics/Pillow/patches/Pillow-0002-Revert-Move-build-config-from-setup.cfg-to-pyproject.patch
deleted file mode 100644
index 577d1c21d8..0000000000
--- a/packages/python/graphics/Pillow/patches/Pillow-0002-Revert-Move-build-config-from-setup.cfg-to-pyproject.patch
+++ /dev/null
@@ -1,87 +0,0 @@
-From 346de8011ac8ece998d9bd857d661cf2bb7479a2 Mon Sep 17 00:00:00 2001
-From: Rudi Heitbaum <rudi@heitbaum.com>
-Date: Sat, 20 Jan 2024 02:20:01 +0000
-Subject: [PATCH] Revert "Move build config from setup.cfg to pyproject.toml"
-
-This partially reverts commit 430920e2a8420bdfcd08eafe6446d6173692e24e.
----
- setup.cfg             | 67 +++++++++++++++++++++++++++++++++++++++++++
- 1 files changed, 67 insertions(+)
- create mode 100644 setup.cfg
-
-diff --git a/setup.cfg b/setup.cfg
-new file mode 100644
-index 000000000..627788cd8
---- /dev/null
-+++ b/setup.cfg
-@@ -0,0 +1,67 @@
-+[metadata]
-+name = Pillow
-+description = Python Imaging Library (Fork)
-+long_description = file: README.md
-+long_description_content_type = text/markdown
-+url = https://python-pillow.org
-+author = Jeffrey A. Clark (Alex)
-+author_email = aclark@aclark.net
-+license = HPND
-+classifiers =
-+    Development Status :: 6 - Mature
-+    License :: OSI Approved :: Historical Permission Notice and Disclaimer (HPND)
-+    Programming Language :: Python :: 3
-+    Programming Language :: Python :: 3 :: Only
-+    Programming Language :: Python :: 3.8
-+    Programming Language :: Python :: 3.9
-+    Programming Language :: Python :: 3.10
-+    Programming Language :: Python :: 3.11
-+    Programming Language :: Python :: 3.12
-+    Programming Language :: Python :: Implementation :: CPython
-+    Programming Language :: Python :: Implementation :: PyPy
-+    Topic :: Multimedia :: Graphics
-+    Topic :: Multimedia :: Graphics :: Capture :: Digital Camera
-+    Topic :: Multimedia :: Graphics :: Capture :: Screen Capture
-+    Topic :: Multimedia :: Graphics :: Graphics Conversion
-+    Topic :: Multimedia :: Graphics :: Viewers
-+keywords = Imaging
-+project_urls =
-+    Documentation=https://pillow.readthedocs.io
-+    Source=https://github.com/python-pillow/Pillow
-+    Funding=https://tidelift.com/subscription/pkg/pypi-pillow?utm_source=pypi-pillow&utm_medium=pypi
-+    Release notes=https://pillow.readthedocs.io/en/stable/releasenotes/index.html
-+    Changelog=https://github.com/python-pillow/Pillow/blob/main/CHANGES.rst
-+    Twitter=https://twitter.com/PythonPillow
-+    Mastodon=https://fosstodon.org/@pillow
-+
-+[options]
-+packages = PIL
-+python_requires = >=3.8
-+include_package_data = True
-+package_dir =
-+    = src
-+
-+[options.extras_require]
-+docs =
-+    furo
-+    olefile
-+    sphinx>=2.4
-+    sphinx-copybutton
-+    sphinx-inline-tabs
-+    sphinx-removed-in
-+    sphinxext-opengraph
-+tests =
-+    check-manifest
-+    coverage
-+    defusedxml
-+    markdown2
-+    olefile
-+    packaging
-+    pyroma
-+    pytest
-+    pytest-cov
-+    pytest-timeout
-+
-+[flake8]
-+extend-ignore = E203
-+max-line-length = 88
--- 
-2.43.0
-
diff --git a/packages/python/graphics/glad/package.mk b/packages/python/graphics/glad/package.mk
index 9a1fe81574..36489ca842 100644
--- a/packages/python/graphics/glad/package.mk
+++ b/packages/python/graphics/glad/package.mk
@@ -7,11 +7,6 @@ PKG_SHA256="61a70234dc7da467cceb07fcdd6dec1213d6143a1b6b19ccc5d7b64cc247ea47"
 PKG_LICENSE="MIT"
 PKG_SITE="https://glad.dav1d.de"
 PKG_URL="https://github.com/Dav1dde/glad/archive/refs/tags/v${PKG_VERSION}.tar.gz"
-PKG_DEPENDS_TARGET="toolchain"
+PKG_DEPENDS_TARGET="setuptools:host"
 PKG_LONGDESC="Multi-Language Vulkan/GL/GLES/EGL/GLX/WGL Loader-Generator based on the official specs"
-PKG_TOOLCHAIN="manual"
-
-makeinstall_host() {
-  export DONT_BUILD_LEGACY_PYC=1
-  exec_thread_safe python3 setup.py install --prefix=${TOOLCHAIN}
-}
+PKG_TOOLCHAIN="python"
diff --git a/packages/python/security/pycryptodome/package.mk b/packages/python/security/pycryptodome/package.mk
index ed656eeee7..0d24d214ad 100644
--- a/packages/python/security/pycryptodome/package.mk
+++ b/packages/python/security/pycryptodome/package.mk
@@ -7,30 +7,22 @@ PKG_SHA256="35019dff66c25db80d0c739b9c7b59bb0f61551897681c6dbdbdd0f7198f780f"
 PKG_LICENSE="BSD"
 PKG_SITE="https://pypi.org/project/pycryptodome"
 PKG_URL="https://github.com/Legrandin/${PKG_NAME}/archive/v${PKG_VERSION}.tar.gz"
-PKG_DEPENDS_TARGET="toolchain Python3"
+PKG_DEPENDS_TARGET="toolchain Python3 setuptools:host"
 PKG_LONGDESC="PyCryptodome is a self-contained Python package of low-level cryptographic primitives."
-PKG_TOOLCHAIN="manual"
+PKG_TOOLCHAIN="python"
 
 pre_configure_target() {
   cd ${PKG_BUILD}
   rm -rf .${TARGET_NAME}
 }
 
-make_target() {
-  python_target_env python3 setup.py build
-}
-
-makeinstall_target() {
-  exec_thread_safe python_target_env python3 setup.py install --root=${INSTALL} --prefix=/usr
-
+post_makeinstall_target() {
   # Remove SelfTest bloat
   find ${INSTALL} -type d -name SelfTest -exec rm -fr "{}" \; 2>/dev/null || true
   find ${INSTALL} -name SOURCES.txt -exec sed -i "/\/SelfTest\//d;" "{}" \;
 
   # Create Cryptodome as an alternative namespace to Crypto (Kodi addons may use either)
   ln -sf /usr/lib/${PKG_PYTHON_VERSION}/site-packages/Crypto ${INSTALL}/usr/lib/${PKG_PYTHON_VERSION}/site-packages/Cryptodome
-}
 
-post_makeinstall_target() {
   python_remove_source
 }
diff --git a/packages/python/system/dbussy/package.mk b/packages/python/system/dbussy/package.mk
index f5e2b243f9..3b0466f7c6 100644
--- a/packages/python/system/dbussy/package.mk
+++ b/packages/python/system/dbussy/package.mk
@@ -7,17 +7,9 @@ PKG_SHA256="857104ef2fd1978323d7c87b32c753d2d178b79adbd13f52cea23511f5195ded"
 PKG_LICENSE="LGPLv2.1+"
 PKG_SITE="https://gitlab.com/ldo/dbussy"
 PKG_URL="https://github.com/ldo/${PKG_NAME}/archive/${PKG_VERSION}.tar.gz"
-PKG_DEPENDS_TARGET="toolchain Python3 dbus"
+PKG_DEPENDS_TARGET="toolchain Python3 dbus setuptools:host"
 PKG_LONGDESC="DBussy is a wrapper around libdbus, written in pure Python"
-PKG_TOOLCHAIN="manual"
-
-make_target() {
-  python3 setup.py build
-}
-
-makeinstall_target() {
-  python3 setup.py install --root=${INSTALL} --prefix=/usr
-}
+PKG_TOOLCHAIN="python"
 
 post_makeinstall_target() {
   python_remove_source
diff --git a/packages/python/system/simplejson/package.mk b/packages/python/system/simplejson/package.mk
index dea383781a..413b56345a 100644
--- a/packages/python/system/simplejson/package.mk
+++ b/packages/python/system/simplejson/package.mk
@@ -8,17 +8,9 @@ PKG_SHA256="8e086896c36210ab6050f2f9f095a5f1e03c83fa0e7f296d6cba425411364680"
 PKG_LICENSE="OSS"
 PKG_SITE="http://pypi.org/project/simplejson"
 PKG_URL="https://files.pythonhosted.org/packages/source/${PKG_NAME:0:1}/${PKG_NAME}/${PKG_NAME}-${PKG_VERSION}.tar.gz"
-PKG_DEPENDS_TARGET="toolchain Python3"
+PKG_DEPENDS_TARGET="toolchain Python3 setuptools:host"
 PKG_LONGDESC="A simple, fast, complete, correct and extensible JSON encoder and decoder for Python 2.5+."
-PKG_TOOLCHAIN="manual"
-
-make_target() {
-  python_target_env python3 setup.py build
-}
-
-makeinstall_target() {
-  exec_thread_safe python_target_env python3 setup.py install --root=${INSTALL} --prefix=/usr
-}
+PKG_TOOLCHAIN="python"
 
 post_makeinstall_target() {
   python_remove_source
diff --git a/scripts/build b/scripts/build
index fc46b8c81d..6d8e990316 100755
--- a/scripts/build
+++ b/scripts/build
@@ -119,7 +119,7 @@ if [ -z "${PKG_TOOLCHAIN}" -o "${PKG_TOOLCHAIN}" = "auto" ]; then
   fi
   _auto_toolchain=" (auto-detect)"
 fi
-if ! listcontains "meson cmake cmake-make configure ninja make autotools manual" "${PKG_TOOLCHAIN}"; then
+if ! listcontains "meson cmake cmake-make configure ninja make autotools manual python-flit python" "${PKG_TOOLCHAIN}"; then
   die "$(print_color "CLR_ERROR" "ERROR:") unknown toolchain ${PKG_TOOLCHAIN}"
 fi
 build_msg "CLR_TOOLCHAIN" "TOOLCHAIN" "${PKG_TOOLCHAIN}${_auto_toolchain}"
@@ -416,6 +416,23 @@ else
       echo "Executing (bootstrap): make ${PKG_MAKE_OPTS_BOOTSTRAP}" | tr -s " "
       make ${PKG_MAKE_OPTS_BOOTSTRAP}
       ;;
+
+    # python builds
+    "python-flit:target")
+      die "$(print_color "CLR_ERROR" "ERROR:") toolchain python-flit should not be used for target!"
+      ;;
+    "python-flit:host")
+      echo "Executing (host): python3 -m flit_core.wheel"
+      DONT_BUILD_LEGACY_PYC=1 python3 -m flit_core.wheel
+      ;;
+    "python:target")
+      echo "Executing (target): python3 -m build -n -w -x ${PKG_PYTHON_OPTS_TARGET}" | tr -s " "
+      python_target_env python3 -m build -n -w -x ${PKG_PYTHON_OPTS_TARGET}
+      ;;
+    "python:host")
+      echo "Executing (host): python3 -m build -n -w -x ${PKG_PYTHON_OPTS_HOST}" | tr -s " "
+      DONT_BUILD_LEGACY_PYC=1 python3 -m build -n -w -x ${PKG_PYTHON_OPTS_HOST}
+      ;;
   esac
 fi
 
@@ -475,6 +492,17 @@ else
     "configure:bootstrap" | "cmake-make:bootstrap" | "autotools:bootstrap" | "make:bootstrap")
       make install ${PKG_MAKEINSTALL_OPTS_BOOTSTRAP}
       ;;
+
+    # python builds
+    "python-flit:target")
+      die "$(print_color "CLR_ERROR" "ERROR:") toolchain python-flit should not be used for target!"
+      ;;
+    "python:target")
+      python3 -m installer --overwrite-existing dist/*.whl -d ${INSTALL} -p /usr
+      ;;
+    "python-flit:host" | "python:host")
+      python3 -m installer --overwrite-existing dist/*.whl
+      ;;
   esac
 fi