diff --git a/packages/addons/addon-depends/system-tools-depends/i2c-tools/package.mk b/packages/addons/addon-depends/system-tools-depends/i2c-tools/package.mk
index 15ab0b800d..fdecc73f7a 100644
--- a/packages/addons/addon-depends/system-tools-depends/i2c-tools/package.mk
+++ b/packages/addons/addon-depends/system-tools-depends/i2c-tools/package.mk
@@ -7,37 +7,26 @@ PKG_SHA256="1f899e43603184fac32f34d72498fc737952dbc9c97a8dd9467fadfdf4600cf9"
 PKG_LICENSE="GPL"
 PKG_SITE="https://i2c.wiki.kernel.org/index.php/I2C_Tools"
 PKG_URL="https://www.kernel.org/pub/software/utils/i2c-tools/${PKG_NAME}-${PKG_VERSION}.tar.xz"
-PKG_DEPENDS_TARGET="toolchain Python3 distutilscross:host"
+PKG_DEPENDS_TARGET="toolchain Python3"
 PKG_LONGDESC="A heterogeneous set of I2C tools for Linux."
 PKG_BUILD_FLAGS="-sysroot"
 
-pre_make_target() {
-  export PYTHONXCPREFIX="${SYSROOT_PREFIX}/usr"
-  export LDSHARED="${CC} -shared"
-}
-
 make_target() {
   make  CC="${CC}" \
         AR="${AR}" \
         CFLAGS="${TARGET_CFLAGS}" \
-        CPPFLAGS="${TARGET_CPPFLAGS} -I${SYSROOT_PREFIX}/usr/include/${PKG_PYTHON_VERSION}" \
-        PYTHON=${TOOLCHAIN}/bin/python3 \
+        CPPFLAGS="${TARGET_CPPFLAGS}" \
         all
 
-  make  EXTRA="py-smbus" \
-        CC="${CC}" \
-        AR="${AR}" \
-        CFLAGS="${TARGET_CFLAGS}" \
-        CPPFLAGS="${TARGET_CPPFLAGS} -I${SYSROOT_PREFIX}/usr/include/${PKG_PYTHON_VERSION}" \
-        PYTHON=${TOOLCHAIN}/bin/python3 \
-        all-python
+  (
+    cd py-smbus
+    python_target_env python3 setup.py build
+  )
 }
 
 makeinstall_target() {
-  make  EXTRA="py-smbus" \
-        DESTDIR=${INSTALL} \
-        PREFIX="/usr" \
-        prefix="/usr" \
-        PYTHON=${TOOLCHAIN}/bin/python3 \
-        install
+  (
+    cd py-smbus
+    exec_thread_safe python_target_env python3 setup.py install --root=${INSTALL} --prefix=/usr
+  )
 }
diff --git a/packages/addons/addon-depends/system-tools-depends/i2c-tools/patches/0001-py-smbus-Use-setuptools-instead-of-distutils.patch b/packages/addons/addon-depends/system-tools-depends/i2c-tools/patches/0001-py-smbus-Use-setuptools-instead-of-distutils.patch
new file mode 100644
index 0000000000..63b2a7f82f
--- /dev/null
+++ b/packages/addons/addon-depends/system-tools-depends/i2c-tools/patches/0001-py-smbus-Use-setuptools-instead-of-distutils.patch
@@ -0,0 +1,38 @@
+From cf3541b8a7ed50782edd05836020d31230fb86c6 Mon Sep 17 00:00:00 2001
+From: Ross Burton <ross.burton@arm.com>
+Date: Wed, 19 Jan 2022 12:08:53 +0100
+Subject: py-smbus: Use setuptools instead of distutils
+
+As per [1], distutils is deprecated in Python 3.10 and will be removed
+entirely in Python 3.12.
+
+As setuptools is essentially an enhanced version of distutils, it's
+trivial to port to that.
+
+[1] https://docs.python.org/3/whatsnew/3.10.html#distutils-deprecated
+
+Signed-off-by: Ross Burton <ross.burton@arm.com>
+Signed-off-by: Jean Delvare <jdelvare@suse.de>
+
+Upstream: https://git.kernel.org/pub/scm/utils/i2c-tools/i2c-tools.git/commit/?id=cf3541b8a7ed50782edd05836020d31230fb86c6
+
+Signed-off-by: Bernd Kuhls <bernd@kuhls.net>
+---
+ py-smbus/setup.py | 2 +-
+ 1 file changed, 1 insertion(+), 1 deletion(-)
+
+diff --git a/py-smbus/setup.py b/py-smbus/setup.py
+index 28a4500..26db33a 100644
+--- a/py-smbus/setup.py
++++ b/py-smbus/setup.py
+@@ -1,6 +1,6 @@
+ #!/usr/bin/env python
+ 
+-from distutils.core import setup, Extension
++from setuptools import setup, Extension
+ 
+ setup(	name="smbus",
+ 	version="1.1",
+-- 
+cgit 
+
diff --git a/packages/addons/addon-depends/system-tools-depends/i2c-tools/patches/pyinstalldir.patch b/packages/addons/addon-depends/system-tools-depends/i2c-tools/patches/pyinstalldir.patch
deleted file mode 100644
index 07ee55d27f..0000000000
--- a/packages/addons/addon-depends/system-tools-depends/i2c-tools/patches/pyinstalldir.patch
+++ /dev/null
@@ -1,12 +0,0 @@
-diff -ur a/py-smbus/Module.mk b/py-smbus/Module.mk
---- a/py-smbus/Module.mk	2014-02-20 09:37:15.711233000 +0100
-+++ b/py-smbus/Module.mk	2019-12-14 08:20:51.730946457 +0100
-@@ -22,7 +22,7 @@
- 	rm -rf py-smbus/build
- 
- install-python:
--	$(DISTUTILS) install
-+	$(DISTUTILS) install --prefix=$(DESTDIR)$(PREFIX)
- 
- all: all-python
-