diff --git a/homeassistant/package_constraints.txt b/homeassistant/package_constraints.txt
index e5e1a85c02f..3eaa0b06619 100644
--- a/homeassistant/package_constraints.txt
+++ b/homeassistant/package_constraints.txt
@@ -23,7 +23,7 @@ bluetooth-data-tools==1.19.3
 cached_ipaddress==0.3.0
 certifi>=2021.5.30
 ciso8601==2.3.1
-cryptography==42.0.8
+cryptography==43.0.0
 dbus-fast==2.22.1
 fnv-hash-fast==0.5.0
 ha-av==10.1.1
@@ -47,7 +47,7 @@ pip>=21.3.1
 psutil-home-assistant==0.0.1
 PyJWT==2.8.0
 PyNaCl==1.5.0
-pyOpenSSL==24.1.0
+pyOpenSSL==24.2.1
 pyserial==3.5
 python-slugify==8.0.4
 PyTurboJPEG==1.7.1
@@ -187,8 +187,8 @@ dacite>=1.7.0
 # Musle wheels for pandas 2.2.0 cannot be build for any architecture.
 pandas==2.1.4
 
-# chacha20poly1305-reuseable==0.12.0 is incompatible with cryptography==42.0.x
-chacha20poly1305-reuseable>=0.12.1
+# chacha20poly1305-reuseable==0.12.x is incompatible with cryptography==43.0.x
+chacha20poly1305-reuseable>=0.13.0
 
 # pycountry<23.12.11 imports setuptools at run time
 # https://github.com/pycountry/pycountry/blob/ea69bab36f00df58624a0e490fdad4ccdc14268b/HISTORY.txt#L39
diff --git a/pyproject.toml b/pyproject.toml
index d0bbc36a5ef..113fef6bfbc 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -50,9 +50,9 @@ dependencies    = [
     "lru-dict==1.3.0",
     "PyJWT==2.8.0",
     # PyJWT has loose dependency. We want the latest one.
-    "cryptography==42.0.8",
+    "cryptography==43.0.0",
     "Pillow==10.4.0",
-    "pyOpenSSL==24.1.0",
+    "pyOpenSSL==24.2.1",
     "orjson==3.10.6",
     "packaging>=23.1",
     "pip>=21.3.1",
diff --git a/requirements.txt b/requirements.txt
index 3eba90158a2..a729f09472b 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -25,9 +25,9 @@ ifaddr==0.2.0
 Jinja2==3.1.4
 lru-dict==1.3.0
 PyJWT==2.8.0
-cryptography==42.0.8
+cryptography==43.0.0
 Pillow==10.4.0
-pyOpenSSL==24.1.0
+pyOpenSSL==24.2.1
 orjson==3.10.6
 packaging>=23.1
 pip>=21.3.1
diff --git a/script/gen_requirements_all.py b/script/gen_requirements_all.py
index 3c593a2bdf7..f887f8113a7 100755
--- a/script/gen_requirements_all.py
+++ b/script/gen_requirements_all.py
@@ -208,8 +208,8 @@ dacite>=1.7.0
 # Musle wheels for pandas 2.2.0 cannot be build for any architecture.
 pandas==2.1.4
 
-# chacha20poly1305-reuseable==0.12.0 is incompatible with cryptography==42.0.x
-chacha20poly1305-reuseable>=0.12.1
+# chacha20poly1305-reuseable==0.12.x is incompatible with cryptography==43.0.x
+chacha20poly1305-reuseable>=0.13.0
 
 # pycountry<23.12.11 imports setuptools at run time
 # https://github.com/pycountry/pycountry/blob/ea69bab36f00df58624a0e490fdad4ccdc14268b/HISTORY.txt#L39