diff --git a/homeassistant/components/homeassistant_green/__init__.py b/homeassistant/components/homeassistant_green/__init__.py
index fbcd2093778..ed86723ab94 100644
--- a/homeassistant/components/homeassistant_green/__init__.py
+++ b/homeassistant/components/homeassistant_green/__init__.py
@@ -1,7 +1,7 @@
 """The Home Assistant Green integration."""
 from __future__ import annotations
 
-from homeassistant.components.hassio import get_os_info
+from homeassistant.components.hassio import get_os_info, is_hassio
 from homeassistant.config_entries import ConfigEntry
 from homeassistant.core import HomeAssistant
 from homeassistant.exceptions import ConfigEntryNotReady
@@ -9,6 +9,11 @@ from homeassistant.exceptions import ConfigEntryNotReady
 
 async def async_setup_entry(hass: HomeAssistant, entry: ConfigEntry) -> bool:
     """Set up a Home Assistant Green config entry."""
+    if not is_hassio(hass):
+        # Not running under supervisor, Home Assistant may have been migrated
+        hass.async_create_task(hass.config_entries.async_remove(entry.entry_id))
+        return False
+
     if (os_info := get_os_info(hass)) is None:
         # The hassio integration has not yet fetched data from the supervisor
         raise ConfigEntryNotReady
diff --git a/homeassistant/components/homeassistant_green/manifest.json b/homeassistant/components/homeassistant_green/manifest.json
index 7c9dd0322ec..d543d562ee3 100644
--- a/homeassistant/components/homeassistant_green/manifest.json
+++ b/homeassistant/components/homeassistant_green/manifest.json
@@ -1,9 +1,10 @@
 {
   "domain": "homeassistant_green",
   "name": "Home Assistant Green",
+  "after_dependencies": ["hassio"],
   "codeowners": ["@home-assistant/core"],
   "config_flow": false,
-  "dependencies": ["hardware", "hassio", "homeassistant_hardware"],
+  "dependencies": ["hardware", "homeassistant_hardware"],
   "documentation": "https://www.home-assistant.io/integrations/homeassistant_green",
   "integration_type": "hardware"
 }
diff --git a/tests/components/homeassistant_green/test_config_flow.py b/tests/components/homeassistant_green/test_config_flow.py
index 84af22509f9..cfac774f77e 100644
--- a/tests/components/homeassistant_green/test_config_flow.py
+++ b/tests/components/homeassistant_green/test_config_flow.py
@@ -3,9 +3,11 @@ from unittest.mock import patch
 
 import pytest
 
+from homeassistant.components.hassio import DOMAIN as HASSIO_DOMAIN
 from homeassistant.components.homeassistant_green.const import DOMAIN
 from homeassistant.core import HomeAssistant
 from homeassistant.data_entry_flow import FlowResultType
+from homeassistant.setup import async_setup_component
 
 from tests.common import MockConfigEntry, MockModule, mock_integration
 
@@ -36,6 +38,7 @@ def mock_set_green_settings():
 async def test_config_flow(hass: HomeAssistant) -> None:
     """Test the config flow."""
     mock_integration(hass, MockModule("hassio"))
+    await async_setup_component(hass, HASSIO_DOMAIN, {})
 
     with patch(
         "homeassistant.components.homeassistant_green.async_setup_entry",
@@ -60,6 +63,7 @@ async def test_config_flow(hass: HomeAssistant) -> None:
 async def test_config_flow_single_entry(hass: HomeAssistant) -> None:
     """Test only a single entry is allowed."""
     mock_integration(hass, MockModule("hassio"))
+    await async_setup_component(hass, HASSIO_DOMAIN, {})
 
     # Setup the config entry
     config_entry = MockConfigEntry(
@@ -115,6 +119,7 @@ async def test_option_flow_led_settings(
 ) -> None:
     """Test updating LED settings."""
     mock_integration(hass, MockModule("hassio"))
+    await async_setup_component(hass, HASSIO_DOMAIN, {})
 
     # Setup the config entry
     config_entry = MockConfigEntry(
@@ -146,6 +151,7 @@ async def test_option_flow_led_settings_unchanged(
 ) -> None:
     """Test updating LED settings."""
     mock_integration(hass, MockModule("hassio"))
+    await async_setup_component(hass, HASSIO_DOMAIN, {})
 
     # Setup the config entry
     config_entry = MockConfigEntry(
@@ -171,6 +177,7 @@ async def test_option_flow_led_settings_unchanged(
 async def test_option_flow_led_settings_fail_1(hass: HomeAssistant) -> None:
     """Test updating LED settings."""
     mock_integration(hass, MockModule("hassio"))
+    await async_setup_component(hass, HASSIO_DOMAIN, {})
 
     # Setup the config entry
     config_entry = MockConfigEntry(
@@ -196,6 +203,7 @@ async def test_option_flow_led_settings_fail_2(
 ) -> None:
     """Test updating LED settings."""
     mock_integration(hass, MockModule("hassio"))
+    await async_setup_component(hass, HASSIO_DOMAIN, {})
 
     # Setup the config entry
     config_entry = MockConfigEntry(
diff --git a/tests/components/homeassistant_green/test_hardware.py b/tests/components/homeassistant_green/test_hardware.py
index 0221bf3a577..c9f958b882c 100644
--- a/tests/components/homeassistant_green/test_hardware.py
+++ b/tests/components/homeassistant_green/test_hardware.py
@@ -3,8 +3,10 @@ from unittest.mock import patch
 
 import pytest
 
+from homeassistant.components.hassio import DOMAIN as HASSIO_DOMAIN
 from homeassistant.components.homeassistant_green.const import DOMAIN
 from homeassistant.core import HomeAssistant
+from homeassistant.setup import async_setup_component
 
 from tests.common import MockConfigEntry, MockModule, mock_integration
 from tests.typing import WebSocketGenerator
@@ -15,6 +17,7 @@ async def test_hardware_info(
 ) -> None:
     """Test we can get the board info."""
     mock_integration(hass, MockModule("hassio"))
+    await async_setup_component(hass, HASSIO_DOMAIN, {})
 
     # Setup the config entry
     config_entry = MockConfigEntry(
@@ -66,6 +69,7 @@ async def test_hardware_info_fail(
 ) -> None:
     """Test async_info raises if os_info is not as expected."""
     mock_integration(hass, MockModule("hassio"))
+    await async_setup_component(hass, HASSIO_DOMAIN, {})
 
     # Setup the config entry
     config_entry = MockConfigEntry(
diff --git a/tests/components/homeassistant_green/test_init.py b/tests/components/homeassistant_green/test_init.py
index 0df7d918039..b183a332f50 100644
--- a/tests/components/homeassistant_green/test_init.py
+++ b/tests/components/homeassistant_green/test_init.py
@@ -1,9 +1,11 @@
 """Test the Home Assistant Green integration."""
 from unittest.mock import patch
 
+from homeassistant.components.hassio import DOMAIN as HASSIO_DOMAIN
 from homeassistant.components.homeassistant_green.const import DOMAIN
 from homeassistant.config_entries import ConfigEntryState
 from homeassistant.core import HomeAssistant
+from homeassistant.setup import async_setup_component
 
 from tests.common import MockConfigEntry, MockModule, mock_integration
 
@@ -11,6 +13,7 @@ from tests.common import MockConfigEntry, MockModule, mock_integration
 async def test_setup_entry(hass: HomeAssistant) -> None:
     """Test setup of a config entry."""
     mock_integration(hass, MockModule("hassio"))
+    await async_setup_component(hass, HASSIO_DOMAIN, {})
 
     # Setup the config entry
     config_entry = MockConfigEntry(
@@ -32,9 +35,32 @@ async def test_setup_entry(hass: HomeAssistant) -> None:
     assert await hass.config_entries.async_unload(config_entry.entry_id)
 
 
+async def test_setup_entry_no_hassio(hass: HomeAssistant) -> None:
+    """Test setup of a config entry without hassio."""
+    # Setup the config entry
+    config_entry = MockConfigEntry(
+        data={},
+        domain=DOMAIN,
+        options={},
+        title="Home Assistant Green",
+    )
+    config_entry.add_to_hass(hass)
+    assert len(hass.config_entries.async_entries()) == 1
+
+    with patch(
+        "homeassistant.components.homeassistant_green.get_os_info"
+    ) as mock_get_os_info:
+        assert not await hass.config_entries.async_setup(config_entry.entry_id)
+        await hass.async_block_till_done()
+
+    assert len(mock_get_os_info.mock_calls) == 0
+    assert len(hass.config_entries.async_entries()) == 0
+
+
 async def test_setup_entry_wrong_board(hass: HomeAssistant) -> None:
     """Test setup of a config entry with wrong board type."""
     mock_integration(hass, MockModule("hassio"))
+    await async_setup_component(hass, HASSIO_DOMAIN, {})
 
     # Setup the config entry
     config_entry = MockConfigEntry(
@@ -60,6 +86,7 @@ async def test_setup_entry_wrong_board(hass: HomeAssistant) -> None:
 async def test_setup_entry_wait_hassio(hass: HomeAssistant) -> None:
     """Test setup of a config entry when hassio has not fetched os_info."""
     mock_integration(hass, MockModule("hassio"))
+    await async_setup_component(hass, HASSIO_DOMAIN, {})
 
     # Setup the config entry
     config_entry = MockConfigEntry(