diff --git a/.coveragerc b/.coveragerc
index e7f99d9982e..426114c6576 100644
--- a/.coveragerc
+++ b/.coveragerc
@@ -520,6 +520,7 @@ omit =
     homeassistant/components/iperf3/*
     homeassistant/components/iqvia/*
     homeassistant/components/irish_rail_transport/sensor.py
+    homeassistant/components/iss/__init__.py
     homeassistant/components/iss/binary_sensor.py
     homeassistant/components/isy994/__init__.py
     homeassistant/components/isy994/binary_sensor.py
diff --git a/CODEOWNERS b/CODEOWNERS
index e5b6ed9798a..cb2573eedb8 100644
--- a/CODEOWNERS
+++ b/CODEOWNERS
@@ -467,6 +467,8 @@ tests/components/iqvia/* @bachya
 homeassistant/components/irish_rail_transport/* @ttroy50
 homeassistant/components/islamic_prayer_times/* @engrbm87
 tests/components/islamic_prayer_times/* @engrbm87
+homeassistant/components/iss/* @DurgNomis-drol
+tests/components/iss/* @DurgNomis-drol
 homeassistant/components/isy994/* @bdraco @shbatm
 tests/components/isy994/* @bdraco @shbatm
 homeassistant/components/izone/* @Swamp-Ig
diff --git a/homeassistant/components/iss/__init__.py b/homeassistant/components/iss/__init__.py
index 51487bdfaf2..af44e621a7f 100644
--- a/homeassistant/components/iss/__init__.py
+++ b/homeassistant/components/iss/__init__.py
@@ -1 +1,27 @@
 """The iss component."""
+from __future__ import annotations
+
+from homeassistant.config_entries import ConfigEntry
+from homeassistant.const import Platform
+from homeassistant.core import HomeAssistant
+
+from .const import DOMAIN
+
+PLATFORMS = [Platform.BINARY_SENSOR]
+
+
+async def async_setup_entry(hass: HomeAssistant, entry: ConfigEntry) -> bool:
+    """Set up this integration using UI."""
+
+    hass.data.setdefault(DOMAIN, {})
+
+    hass.config_entries.async_setup_platforms(entry, PLATFORMS)
+
+    return True
+
+
+async def async_unload_entry(hass: HomeAssistant, entry: ConfigEntry) -> bool:
+    """Handle removal of an entry."""
+    if unload_ok := await hass.config_entries.async_unload_platforms(entry, PLATFORMS):
+        del hass.data[DOMAIN]
+    return unload_ok
diff --git a/homeassistant/components/iss/binary_sensor.py b/homeassistant/components/iss/binary_sensor.py
index eab1294ad10..5272053a517 100644
--- a/homeassistant/components/iss/binary_sensor.py
+++ b/homeassistant/components/iss/binary_sensor.py
@@ -1,4 +1,4 @@
-"""Support for International Space Station binary sensor."""
+"""Support for iss binary sensor."""
 from __future__ import annotations
 
 from datetime import timedelta
@@ -10,6 +10,7 @@ from requests.exceptions import HTTPError
 import voluptuous as vol
 
 from homeassistant.components.binary_sensor import PLATFORM_SCHEMA, BinarySensorEntity
+from homeassistant.config_entries import SOURCE_IMPORT, ConfigEntry
 from homeassistant.const import (
     ATTR_LATITUDE,
     ATTR_LONGITUDE,
@@ -22,6 +23,8 @@ from homeassistant.helpers.entity_platform import AddEntitiesCallback
 from homeassistant.helpers.typing import ConfigType, DiscoveryInfoType
 from homeassistant.util import Throttle
 
+from .const import DOMAIN
+
 _LOGGER = logging.getLogger(__name__)
 
 ATTR_ISS_NEXT_RISE = "next_rise"
@@ -46,22 +49,40 @@ def setup_platform(
     add_entities: AddEntitiesCallback,
     discovery_info: DiscoveryInfoType | None = None,
 ) -> None:
-    """Set up the ISS binary sensor."""
-    if None in (hass.config.latitude, hass.config.longitude):
-        _LOGGER.error("Latitude or longitude not set in Home Assistant config")
-        return
+    """Import ISS configuration from yaml."""
+    _LOGGER.warning(
+        "Configuration of the iss platform in YAML is deprecated and will be "
+        "removed in Home Assistant 2022.5; Your existing configuration "
+        "has been imported into the UI automatically and can be safely removed "
+        "from your configuration.yaml file"
+    )
+    hass.async_create_task(
+        hass.config_entries.flow.async_init(
+            DOMAIN,
+            context={"source": SOURCE_IMPORT},
+            data=config,
+        )
+    )
+
+
+async def async_setup_entry(
+    hass: HomeAssistant,
+    entry: ConfigEntry,
+    async_add_entities: AddEntitiesCallback,
+) -> None:
+    """Set up the sensor platform."""
+
+    name = entry.data.get(CONF_NAME, DEFAULT_NAME)
+    show_on_map = entry.data.get(CONF_SHOW_ON_MAP, False)
 
     try:
         iss_data = IssData(hass.config.latitude, hass.config.longitude)
-        iss_data.update()
+        await hass.async_add_executor_job(iss_data.update)
     except HTTPError as error:
         _LOGGER.error(error)
         return
 
-    name = config.get(CONF_NAME)
-    show_on_map = config.get(CONF_SHOW_ON_MAP)
-
-    add_entities([IssBinarySensor(iss_data, name, show_on_map)], True)
+    async_add_entities([IssBinarySensor(iss_data, name, show_on_map)], True)
 
 
 class IssBinarySensor(BinarySensorEntity):
diff --git a/homeassistant/components/iss/config_flow.py b/homeassistant/components/iss/config_flow.py
new file mode 100644
index 00000000000..e1703b54acb
--- /dev/null
+++ b/homeassistant/components/iss/config_flow.py
@@ -0,0 +1,48 @@
+"""Config flow to configure iss component."""
+
+import voluptuous as vol
+
+from homeassistant import config_entries
+from homeassistant.const import CONF_NAME, CONF_SHOW_ON_MAP
+from homeassistant.data_entry_flow import FlowResult
+
+from .const import DOMAIN
+
+
+class ConfigFlow(config_entries.ConfigFlow, domain=DOMAIN):
+    """Config flow for iss component."""
+
+    VERSION = 1
+
+    async def async_step_user(self, user_input=None) -> FlowResult:
+        """Handle a flow initialized by the user."""
+        # Check if already configured
+        if self._async_current_entries():
+            return self.async_abort(reason="single_instance_allowed")
+
+        # Check if location have been defined.
+        if not self.hass.config.latitude and not self.hass.config.longitude:
+            return self.async_abort(reason="latitude_longitude_not_defined")
+
+        if user_input is not None:
+            return self.async_create_entry(
+                title="International Space Station", data=user_input
+            )
+
+        return self.async_show_form(
+            step_id="user",
+            data_schema=vol.Schema(
+                {
+                    vol.Optional(CONF_SHOW_ON_MAP, default=False): bool,
+                }
+            ),
+        )
+
+    async def async_step_import(self, conf: dict) -> FlowResult:
+        """Import a configuration from configuration.yaml."""
+        return await self.async_step_user(
+            user_input={
+                CONF_NAME: conf[CONF_NAME],
+                CONF_SHOW_ON_MAP: conf[CONF_SHOW_ON_MAP],
+            }
+        )
diff --git a/homeassistant/components/iss/const.py b/homeassistant/components/iss/const.py
new file mode 100644
index 00000000000..3d240041b67
--- /dev/null
+++ b/homeassistant/components/iss/const.py
@@ -0,0 +1,3 @@
+"""Constants for iss."""
+
+DOMAIN = "iss"
diff --git a/homeassistant/components/iss/manifest.json b/homeassistant/components/iss/manifest.json
index 740dbbb9ff4..bd1aa967f07 100644
--- a/homeassistant/components/iss/manifest.json
+++ b/homeassistant/components/iss/manifest.json
@@ -1,9 +1,10 @@
 {
   "domain": "iss",
+  "config_flow": true,
   "name": "International Space Station (ISS)",
   "documentation": "https://www.home-assistant.io/integrations/iss",
   "requirements": ["pyiss==1.0.1"],
-  "codeowners": [],
+  "codeowners": ["@DurgNomis-drol"],
   "iot_class": "cloud_polling",
   "loggers": ["pyiss"]
 }
diff --git a/homeassistant/components/iss/strings.json b/homeassistant/components/iss/strings.json
new file mode 100644
index 00000000000..cdbaecbeba5
--- /dev/null
+++ b/homeassistant/components/iss/strings.json
@@ -0,0 +1,16 @@
+{
+    "config": {
+      "step": {
+        "user": {
+          "description": "Do you want to configure the Internation Space Station?",
+          "data": {
+            "show_on_map": "Show on map?"
+          }
+        }
+      },
+      "abort": {
+        "single_instance_allowed": "[%key:common::config_flow::abort::single_instance_allowed%]",
+        "latitude_longitude_not_defined": "Latitude and longitude is not defind in Home Assistant."
+      }
+    }
+  }
\ No newline at end of file
diff --git a/homeassistant/components/iss/translations/en.json b/homeassistant/components/iss/translations/en.json
new file mode 100644
index 00000000000..13483418ffa
--- /dev/null
+++ b/homeassistant/components/iss/translations/en.json
@@ -0,0 +1,16 @@
+{
+    "config": {
+        "abort": {
+            "latitude_longitude_not_defined": "Latitude and longitude is not defind in Home Assistant.",
+            "single_instance_allowed": "Already configured. Only a single configuration possible."
+        },
+        "step": {
+            "user": {
+                "data": {
+                    "show_on_map": "Show on map?"
+                },
+                "description": "Do you want to configure the Internation Space Station?"
+            }
+        }
+    }
+}
\ No newline at end of file
diff --git a/homeassistant/generated/config_flows.py b/homeassistant/generated/config_flows.py
index bf64bc4a51c..365aa903b09 100644
--- a/homeassistant/generated/config_flows.py
+++ b/homeassistant/generated/config_flows.py
@@ -159,6 +159,7 @@ FLOWS = [
     "ipp",
     "iqvia",
     "islamic_prayer_times",
+    "iss",
     "isy994",
     "izone",
     "jellyfin",
diff --git a/requirements_test_all.txt b/requirements_test_all.txt
index 83086ebb786..52b93948e43 100644
--- a/requirements_test_all.txt
+++ b/requirements_test_all.txt
@@ -998,6 +998,9 @@ pyipp==0.11.0
 # homeassistant.components.iqvia
 pyiqvia==2021.11.0
 
+# homeassistant.components.iss
+pyiss==1.0.1
+
 # homeassistant.components.isy994
 pyisy==3.0.1
 
diff --git a/tests/components/iss/__init__.py b/tests/components/iss/__init__.py
new file mode 100644
index 00000000000..7fa75a42ccb
--- /dev/null
+++ b/tests/components/iss/__init__.py
@@ -0,0 +1 @@
+"""Tests for the iss component."""
diff --git a/tests/components/iss/test_config_flow.py b/tests/components/iss/test_config_flow.py
new file mode 100644
index 00000000000..a20a8729f55
--- /dev/null
+++ b/tests/components/iss/test_config_flow.py
@@ -0,0 +1,78 @@
+"""Test iss config flow."""
+from unittest.mock import patch
+
+from homeassistant import data_entry_flow
+from homeassistant.components.iss.binary_sensor import DEFAULT_NAME
+from homeassistant.components.iss.const import DOMAIN
+from homeassistant.config import async_process_ha_core_config
+from homeassistant.config_entries import SOURCE_IMPORT, SOURCE_USER
+from homeassistant.const import CONF_NAME, CONF_SHOW_ON_MAP
+
+from tests.common import MockConfigEntry
+
+
+async def test_import(hass):
+    """Test entry will be imported."""
+
+    imported_config = {CONF_NAME: DEFAULT_NAME, CONF_SHOW_ON_MAP: False}
+
+    with patch("homeassistant.components.iss.async_setup_entry", return_value=True):
+
+        result = await hass.config_entries.flow.async_init(
+            DOMAIN, context={"source": SOURCE_IMPORT}, data=imported_config
+        )
+        assert result.get("type") == data_entry_flow.RESULT_TYPE_CREATE_ENTRY
+        assert result.get("result").data == imported_config
+
+
+async def test_create_entry(hass):
+    """Test we can finish a config flow."""
+
+    result = await hass.config_entries.flow.async_init(
+        DOMAIN, context={"source": SOURCE_USER}
+    )
+
+    assert result.get("type") == data_entry_flow.RESULT_TYPE_FORM
+    assert result.get("step_id") == SOURCE_USER
+
+    with patch("homeassistant.components.iss.async_setup_entry", return_value=True):
+
+        result = await hass.config_entries.flow.async_configure(
+            result["flow_id"],
+            {CONF_SHOW_ON_MAP: True},
+        )
+
+        assert result.get("type") == data_entry_flow.RESULT_TYPE_CREATE_ENTRY
+        assert result.get("result").data[CONF_SHOW_ON_MAP] is True
+
+
+async def test_integration_already_exists(hass):
+    """Test we only allow a single config flow."""
+
+    MockConfigEntry(
+        domain=DOMAIN,
+        data={},
+    ).add_to_hass(hass)
+
+    result = await hass.config_entries.flow.async_init(
+        DOMAIN, context={"source": SOURCE_USER}, data={CONF_SHOW_ON_MAP: False}
+    )
+
+    assert result.get("type") == data_entry_flow.RESULT_TYPE_ABORT
+    assert result.get("reason") == "single_instance_allowed"
+
+
+async def test_abort_no_home(hass):
+    """Test we don't create an entry if no coordinates are set."""
+
+    await async_process_ha_core_config(
+        hass,
+        {"latitude": 0.0, "longitude": 0.0},
+    )
+
+    result = await hass.config_entries.flow.async_init(
+        DOMAIN, context={"source": SOURCE_USER}, data={CONF_SHOW_ON_MAP: False}
+    )
+
+    assert result.get("type") == data_entry_flow.RESULT_TYPE_ABORT
+    assert result.get("reason") == "latitude_longitude_not_defined"