diff --git a/homeassistant/components/compensation/manifest.json b/homeassistant/components/compensation/manifest.json
index ac82938b97b..a7e714a80b8 100644
--- a/homeassistant/components/compensation/manifest.json
+++ b/homeassistant/components/compensation/manifest.json
@@ -5,5 +5,5 @@
   "documentation": "https://www.home-assistant.io/integrations/compensation",
   "iot_class": "calculated",
   "quality_scale": "legacy",
-  "requirements": ["numpy==2.2.0"]
+  "requirements": ["numpy==2.2.1"]
 }
diff --git a/homeassistant/components/iqvia/manifest.json b/homeassistant/components/iqvia/manifest.json
index 0236b72c89d..4a308d02b3d 100644
--- a/homeassistant/components/iqvia/manifest.json
+++ b/homeassistant/components/iqvia/manifest.json
@@ -7,5 +7,5 @@
   "integration_type": "service",
   "iot_class": "cloud_polling",
   "loggers": ["pyiqvia"],
-  "requirements": ["numpy==2.2.0", "pyiqvia==2022.04.0"]
+  "requirements": ["numpy==2.2.1", "pyiqvia==2022.04.0"]
 }
diff --git a/homeassistant/components/stream/manifest.json b/homeassistant/components/stream/manifest.json
index b9368565e2f..e0321e306e3 100644
--- a/homeassistant/components/stream/manifest.json
+++ b/homeassistant/components/stream/manifest.json
@@ -7,5 +7,5 @@
   "integration_type": "system",
   "iot_class": "local_push",
   "quality_scale": "internal",
-  "requirements": ["PyTurboJPEG==1.7.5", "av==13.1.0", "numpy==2.2.0"]
+  "requirements": ["PyTurboJPEG==1.7.5", "av==13.1.0", "numpy==2.2.1"]
 }
diff --git a/homeassistant/components/tensorflow/manifest.json b/homeassistant/components/tensorflow/manifest.json
index 16de386b15d..d07dc53ee46 100644
--- a/homeassistant/components/tensorflow/manifest.json
+++ b/homeassistant/components/tensorflow/manifest.json
@@ -10,7 +10,7 @@
     "tensorflow==2.5.0",
     "tf-models-official==2.5.0",
     "pycocotools==2.0.6",
-    "numpy==2.2.0",
+    "numpy==2.2.1",
     "Pillow==11.0.0"
   ]
 }
diff --git a/homeassistant/components/trend/manifest.json b/homeassistant/components/trend/manifest.json
index 85012939fc1..69e8daa3ce7 100644
--- a/homeassistant/components/trend/manifest.json
+++ b/homeassistant/components/trend/manifest.json
@@ -7,5 +7,5 @@
   "integration_type": "helper",
   "iot_class": "calculated",
   "quality_scale": "internal",
-  "requirements": ["numpy==2.2.0"]
+  "requirements": ["numpy==2.2.1"]
 }
diff --git a/homeassistant/package_constraints.txt b/homeassistant/package_constraints.txt
index a66137ef8c3..3c75c404794 100644
--- a/homeassistant/package_constraints.txt
+++ b/homeassistant/package_constraints.txt
@@ -116,7 +116,7 @@ httpcore==1.0.5
 hyperframe>=5.2.0
 
 # Ensure we run compatible with musllinux build env
-numpy==2.2.0
+numpy==2.2.1
 pandas~=2.2.3
 
 # Constrain multidict to avoid typing issues
diff --git a/requirements_all.txt b/requirements_all.txt
index ab6fccd9310..9a14ed8a923 100644
--- a/requirements_all.txt
+++ b/requirements_all.txt
@@ -1504,7 +1504,7 @@ numato-gpio==0.13.0
 # homeassistant.components.stream
 # homeassistant.components.tensorflow
 # homeassistant.components.trend
-numpy==2.2.0
+numpy==2.2.1
 
 # homeassistant.components.nyt_games
 nyt_games==0.4.4
diff --git a/requirements_test_all.txt b/requirements_test_all.txt
index ccc0b921727..62fbedf4c6a 100644
--- a/requirements_test_all.txt
+++ b/requirements_test_all.txt
@@ -1258,7 +1258,7 @@ numato-gpio==0.13.0
 # homeassistant.components.stream
 # homeassistant.components.tensorflow
 # homeassistant.components.trend
-numpy==2.2.0
+numpy==2.2.1
 
 # homeassistant.components.nyt_games
 nyt_games==0.4.4
diff --git a/script/gen_requirements_all.py b/script/gen_requirements_all.py
index 86179ac228f..59ecec939f3 100755
--- a/script/gen_requirements_all.py
+++ b/script/gen_requirements_all.py
@@ -148,7 +148,7 @@ httpcore==1.0.5
 hyperframe>=5.2.0
 
 # Ensure we run compatible with musllinux build env
-numpy==2.2.0
+numpy==2.2.1
 pandas~=2.2.3
 
 # Constrain multidict to avoid typing issues