diff --git a/Dockerfile b/Dockerfile
index 917b9ca19c4..171d08731a9 100644
--- a/Dockerfile
+++ b/Dockerfile
@@ -13,7 +13,7 @@ ENV \
 ARG QEMU_CPU
 
 # Install uv
-RUN pip3 install uv==0.5.18
+RUN pip3 install uv==0.5.21
 
 WORKDIR /usr/src
 
diff --git a/homeassistant/package_constraints.txt b/homeassistant/package_constraints.txt
index 133c5bb76ed..a804cb90cf3 100644
--- a/homeassistant/package_constraints.txt
+++ b/homeassistant/package_constraints.txt
@@ -67,7 +67,7 @@ standard-telnetlib==3.13.0;python_version>='3.13'
 typing-extensions>=4.12.2,<5.0
 ulid-transform==1.2.0
 urllib3>=1.26.5,<2
-uv==0.5.18
+uv==0.5.21
 voluptuous-openapi==0.0.6
 voluptuous-serialize==2.6.0
 voluptuous==0.15.2
diff --git a/pyproject.toml b/pyproject.toml
index 73795f4ccd5..88a5410941f 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -76,7 +76,7 @@ dependencies    = [
     # Temporary setting an upper bound, to prevent compat issues with urllib3>=2
     # https://github.com/home-assistant/core/issues/97248
     "urllib3>=1.26.5,<2",
-    "uv==0.5.18",
+    "uv==0.5.21",
     "voluptuous==0.15.2",
     "voluptuous-serialize==2.6.0",
     "voluptuous-openapi==0.0.6",
diff --git a/requirements.txt b/requirements.txt
index 6b934c101e7..91a5d131b3b 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -45,7 +45,7 @@ standard-telnetlib==3.13.0;python_version>='3.13'
 typing-extensions>=4.12.2,<5.0
 ulid-transform==1.2.0
 urllib3>=1.26.5,<2
-uv==0.5.18
+uv==0.5.21
 voluptuous==0.15.2
 voluptuous-serialize==2.6.0
 voluptuous-openapi==0.0.6
diff --git a/script/hassfest/docker/Dockerfile b/script/hassfest/docker/Dockerfile
index a64859274d0..21b98d30f1e 100644
--- a/script/hassfest/docker/Dockerfile
+++ b/script/hassfest/docker/Dockerfile
@@ -14,7 +14,7 @@ WORKDIR "/github/workspace"
 COPY . /usr/src/homeassistant
 
 # Uv is only needed during build
-RUN --mount=from=ghcr.io/astral-sh/uv:0.5.18,source=/uv,target=/bin/uv \
+RUN --mount=from=ghcr.io/astral-sh/uv:0.5.21,source=/uv,target=/bin/uv \
     # Uv creates a lock file in /tmp
     --mount=type=tmpfs,target=/tmp \
     # Required for PyTurboJPEG