diff --git a/homeassistant/components/smartthings/__init__.py b/homeassistant/components/smartthings/__init__.py
index b7850bc9333..969df42bed9 100644
--- a/homeassistant/components/smartthings/__init__.py
+++ b/homeassistant/components/smartthings/__init__.py
@@ -112,9 +112,11 @@ async def async_setup_entry(hass: HomeAssistant, entry: SmartThingsConfigEntry)
                 device_registry.async_get_or_create(
                     config_entry_id=entry.entry_id,
                     identifiers={(DOMAIN, dev.device.device_id)},
-                    connections={
-                        (dr.CONNECTION_NETWORK_MAC, dev.device.hub.mac_address)
-                    },
+                    connections=(
+                        {(dr.CONNECTION_NETWORK_MAC, dev.device.hub.mac_address)}
+                        if dev.device.hub.mac_address
+                        else set()
+                    ),
                     name=dev.device.label,
                     sw_version=dev.device.hub.firmware_version,
                     model=dev.device.hub.hardware_type,
diff --git a/homeassistant/components/smartthings/manifest.json b/homeassistant/components/smartthings/manifest.json
index 7a25dc2ac13..22926e70ba0 100644
--- a/homeassistant/components/smartthings/manifest.json
+++ b/homeassistant/components/smartthings/manifest.json
@@ -29,5 +29,5 @@
   "documentation": "https://www.home-assistant.io/integrations/smartthings",
   "iot_class": "cloud_push",
   "loggers": ["pysmartthings"],
-  "requirements": ["pysmartthings==2.4.1"]
+  "requirements": ["pysmartthings==2.5.0"]
 }
diff --git a/requirements_all.txt b/requirements_all.txt
index a56afd43961..e6e91eabbe3 100644
--- a/requirements_all.txt
+++ b/requirements_all.txt
@@ -2310,7 +2310,7 @@ pysma==0.7.5
 pysmappee==0.2.29
 
 # homeassistant.components.smartthings
-pysmartthings==2.4.1
+pysmartthings==2.5.0
 
 # homeassistant.components.smarty
 pysmarty2==0.10.2
diff --git a/requirements_test_all.txt b/requirements_test_all.txt
index 40311657000..3f0115f78f4 100644
--- a/requirements_test_all.txt
+++ b/requirements_test_all.txt
@@ -1882,7 +1882,7 @@ pysma==0.7.5
 pysmappee==0.2.29
 
 # homeassistant.components.smartthings
-pysmartthings==2.4.1
+pysmartthings==2.5.0
 
 # homeassistant.components.smarty
 pysmarty2==0.10.2