diff --git a/homeassistant/config_entries.py b/homeassistant/config_entries.py
index df4cb651528..bbea3f1d5f8 100644
--- a/homeassistant/config_entries.py
+++ b/homeassistant/config_entries.py
@@ -445,6 +445,10 @@ class ConfigEntry:
 
             async def setup_again(*_: Any) -> None:
                 """Run setup again."""
+                # Check again when we fire in case shutdown
+                # has started so we do not block shutdown
+                if hass.is_stopping:
+                    return
                 self._async_cancel_retry_setup = None
                 await self.async_setup(hass, integration=integration, tries=tries)
 
diff --git a/tests/test_config_entries.py b/tests/test_config_entries.py
index aecdc79da92..12b77aded8f 100644
--- a/tests/test_config_entries.py
+++ b/tests/test_config_entries.py
@@ -29,6 +29,7 @@ from homeassistant.helpers import entity_registry as er
 from homeassistant.helpers.update_coordinator import DataUpdateCoordinator
 from homeassistant.setup import async_set_domains_to_be_loaded, async_setup_component
 from homeassistant.util import dt
+import homeassistant.util.dt as dt_util
 
 from .common import (
     MockConfigEntry,
@@ -999,6 +1000,27 @@ async def test_setup_retrying_during_unload_before_started(hass: HomeAssistant)
     )
 
 
+async def test_setup_does_not_retry_during_shutdown(hass: HomeAssistant) -> None:
+    """Test we do not retry when HASS is shutting down."""
+    entry = MockConfigEntry(domain="test")
+
+    mock_setup_entry = AsyncMock(side_effect=ConfigEntryNotReady)
+    mock_integration(hass, MockModule("test", async_setup_entry=mock_setup_entry))
+    mock_entity_platform(hass, "config_flow.test", None)
+
+    await entry.async_setup(hass)
+
+    assert entry.state is config_entries.ConfigEntryState.SETUP_RETRY
+    assert len(mock_setup_entry.mock_calls) == 1
+
+    hass.state = CoreState.stopping
+    async_fire_time_changed(hass, dt_util.utcnow() + timedelta(minutes=5))
+    await hass.async_block_till_done()
+
+    assert entry.state is config_entries.ConfigEntryState.SETUP_RETRY
+    assert len(mock_setup_entry.mock_calls) == 1
+
+
 async def test_create_entry_options(hass: HomeAssistant) -> None:
     """Test a config entry being created with options."""