diff --git a/.coveragerc b/.coveragerc
index 7e3bd6c1e50..d3c5094d4b1 100644
--- a/.coveragerc
+++ b/.coveragerc
@@ -721,6 +721,9 @@ omit =
     homeassistant/components/mochad/*
     homeassistant/components/modbus/climate.py
     homeassistant/components/modem_callerid/sensor.py
+    homeassistant/components/moehlenhoff_alpha2/__init__.py
+    homeassistant/components/moehlenhoff_alpha2/climate.py
+    homeassistant/components/moehlenhoff_alpha2/const.py
     homeassistant/components/motion_blinds/__init__.py
     homeassistant/components/motion_blinds/const.py
     homeassistant/components/motion_blinds/cover.py
diff --git a/CODEOWNERS b/CODEOWNERS
index 1becdf7a502..20fe7d086e0 100644
--- a/CODEOWNERS
+++ b/CODEOWNERS
@@ -574,6 +574,8 @@ homeassistant/components/modem_callerid/* @tkdrob
 tests/components/modem_callerid/* @tkdrob
 homeassistant/components/modern_forms/* @wonderslug
 tests/components/modern_forms/* @wonderslug
+homeassistant/components/moehlenhoff_alpha2/* @j-a-n
+tests/components/moehlenhoff_alpha2/* @j-a-n
 homeassistant/components/monoprice/* @etsinko @OnFreund
 tests/components/monoprice/* @etsinko @OnFreund
 homeassistant/components/moon/* @fabaff
diff --git a/homeassistant/components/moehlenhoff_alpha2/__init__.py b/homeassistant/components/moehlenhoff_alpha2/__init__.py
new file mode 100644
index 00000000000..62e18917dc6
--- /dev/null
+++ b/homeassistant/components/moehlenhoff_alpha2/__init__.py
@@ -0,0 +1,159 @@
+"""Support for the Moehlenhoff Alpha2."""
+from __future__ import annotations
+
+from datetime import timedelta
+import logging
+
+import aiohttp
+from moehlenhoff_alpha2 import Alpha2Base
+
+from homeassistant.config_entries import ConfigEntry
+from homeassistant.const import Platform
+from homeassistant.core import HomeAssistant
+from homeassistant.exceptions import HomeAssistantError
+from homeassistant.helpers.update_coordinator import DataUpdateCoordinator
+
+from .const import DOMAIN
+
+_LOGGER = logging.getLogger(__name__)
+
+PLATFORMS = [Platform.CLIMATE]
+
+UPDATE_INTERVAL = timedelta(seconds=60)
+
+
+async def async_setup_entry(hass: HomeAssistant, entry: ConfigEntry) -> bool:
+    """Set up a config entry."""
+    base = Alpha2Base(entry.data["host"])
+    coordinator = Alpha2BaseCoordinator(hass, base)
+
+    await coordinator.async_config_entry_first_refresh()
+
+    hass.data.setdefault(DOMAIN, {})
+    hass.data[DOMAIN][entry.entry_id] = coordinator
+
+    hass.config_entries.async_setup_platforms(entry, PLATFORMS)
+
+    return True
+
+
+async def async_unload_entry(hass: HomeAssistant, entry: ConfigEntry) -> bool:
+    """Unload a config entry."""
+    unload_ok = await hass.config_entries.async_unload_platforms(entry, PLATFORMS)
+
+    if unload_ok and entry.entry_id in hass.data[DOMAIN]:
+        hass.data[DOMAIN].pop(entry.entry_id)
+
+    return unload_ok
+
+
+async def update_listener(hass: HomeAssistant, entry: ConfigEntry) -> None:
+    """Handle options update."""
+    await hass.config_entries.async_reload(entry.entry_id)
+
+
+class Alpha2BaseCoordinator(DataUpdateCoordinator[dict[str, dict]]):
+    """Keep the base instance in one place and centralize the update."""
+
+    def __init__(self, hass: HomeAssistant, base: Alpha2Base) -> None:
+        """Initialize Alpha2Base data updater."""
+        self.base = base
+        super().__init__(
+            hass=hass,
+            logger=_LOGGER,
+            name="alpha2_base",
+            update_interval=UPDATE_INTERVAL,
+        )
+
+    async def _async_update_data(self) -> dict[str, dict]:
+        """Fetch the latest data from the source."""
+        await self.base.update_data()
+        return {ha["ID"]: ha for ha in self.base.heat_areas if ha.get("ID")}
+
+    def get_cooling(self) -> bool:
+        """Return if cooling mode is enabled."""
+        return self.base.cooling
+
+    async def async_set_cooling(self, enabled: bool) -> None:
+        """Enable or disable cooling mode."""
+        await self.base.set_cooling(enabled)
+        for update_callback in self._listeners:
+            update_callback()
+
+    async def async_set_target_temperature(
+        self, heat_area_id: str, target_temperature: float
+    ) -> None:
+        """Set the target temperature of the given heat area."""
+        _LOGGER.debug(
+            "Setting target temperature of heat area %s to %0.1f",
+            heat_area_id,
+            target_temperature,
+        )
+
+        update_data = {"T_TARGET": target_temperature}
+        is_cooling = self.get_cooling()
+        heat_area_mode = self.data[heat_area_id]["HEATAREA_MODE"]
+        if heat_area_mode == 1:
+            if is_cooling:
+                update_data["T_COOL_DAY"] = target_temperature
+            else:
+                update_data["T_HEAT_DAY"] = target_temperature
+        elif heat_area_mode == 2:
+            if is_cooling:
+                update_data["T_COOL_NIGHT"] = target_temperature
+            else:
+                update_data["T_HEAT_NIGHT"] = target_temperature
+
+        try:
+            await self.base.update_heat_area(heat_area_id, update_data)
+        except aiohttp.ClientError as http_err:
+            raise HomeAssistantError(
+                "Failed to set target temperature, communication error with alpha2 base"
+            ) from http_err
+        self.data[heat_area_id].update(update_data)
+        for update_callback in self._listeners:
+            update_callback()
+
+    async def async_set_heat_area_mode(
+        self, heat_area_id: str, heat_area_mode: int
+    ) -> None:
+        """Set the mode of the given heat area."""
+        # HEATAREA_MODE: 0=Auto, 1=Tag, 2=Nacht
+        if heat_area_mode not in (0, 1, 2):
+            ValueError(f"Invalid heat area mode: {heat_area_mode}")
+        _LOGGER.debug(
+            "Setting mode of heat area %s to %d",
+            heat_area_id,
+            heat_area_mode,
+        )
+        try:
+            await self.base.update_heat_area(
+                heat_area_id, {"HEATAREA_MODE": heat_area_mode}
+            )
+        except aiohttp.ClientError as http_err:
+            raise HomeAssistantError(
+                "Failed to set heat area mode, communication error with alpha2 base"
+            ) from http_err
+
+        self.data[heat_area_id]["HEATAREA_MODE"] = heat_area_mode
+        is_cooling = self.get_cooling()
+        if heat_area_mode == 1:
+            if is_cooling:
+                self.data[heat_area_id]["T_TARGET"] = self.data[heat_area_id][
+                    "T_COOL_DAY"
+                ]
+            else:
+                self.data[heat_area_id]["T_TARGET"] = self.data[heat_area_id][
+                    "T_HEAT_DAY"
+                ]
+        elif heat_area_mode == 2:
+            if is_cooling:
+                self.data[heat_area_id]["T_TARGET"] = self.data[heat_area_id][
+                    "T_COOL_NIGHT"
+                ]
+            else:
+                self.data[heat_area_id]["T_TARGET"] = self.data[heat_area_id][
+                    "T_HEAT_NIGHT"
+                ]
+        for update_callback in self._listeners:
+            update_callback()
diff --git a/homeassistant/components/moehlenhoff_alpha2/climate.py b/homeassistant/components/moehlenhoff_alpha2/climate.py
new file mode 100644
index 00000000000..da536c4bd06
--- /dev/null
+++ b/homeassistant/components/moehlenhoff_alpha2/climate.py
@@ -0,0 +1,131 @@
+"""Support for Alpha2 room control unit via Alpha2 base."""
+import logging
+
+from homeassistant.components.climate import ClimateEntity
+from homeassistant.components.climate.const import (
+    CURRENT_HVAC_COOL,
+    CURRENT_HVAC_HEAT,
+    CURRENT_HVAC_IDLE,
+    HVAC_MODE_COOL,
+    HVAC_MODE_HEAT,
+    SUPPORT_PRESET_MODE,
+    SUPPORT_TARGET_TEMPERATURE,
+)
+from homeassistant.config_entries import ConfigEntry
+from homeassistant.const import ATTR_TEMPERATURE, TEMP_CELSIUS
+from homeassistant.core import HomeAssistant
+from homeassistant.helpers.entity_platform import AddEntitiesCallback
+from homeassistant.helpers.update_coordinator import CoordinatorEntity
+
+from . import Alpha2BaseCoordinator
+from .const import DOMAIN, PRESET_AUTO, PRESET_DAY, PRESET_NIGHT
+
+_LOGGER = logging.getLogger(__name__)
+
+
+async def async_setup_entry(
+    hass: HomeAssistant,
+    config_entry: ConfigEntry,
+    async_add_entities: AddEntitiesCallback,
+) -> None:
+    """Add Alpha2Climate entities from a config_entry."""
+
+    coordinator: Alpha2BaseCoordinator = hass.data[DOMAIN][config_entry.entry_id]
+
+    async_add_entities(
+        Alpha2Climate(coordinator, heat_area_id) for heat_area_id in coordinator.data
+    )
+
+
+# https://developers.home-assistant.io/docs/core/entity/climate/
+class Alpha2Climate(CoordinatorEntity, ClimateEntity):
+    """Alpha2 ClimateEntity."""
+
+    coordinator: Alpha2BaseCoordinator
+    target_temperature_step = 0.2
+
+    _attr_supported_features = SUPPORT_TARGET_TEMPERATURE | SUPPORT_PRESET_MODE
+    _attr_hvac_modes = [HVAC_MODE_HEAT, HVAC_MODE_COOL]
+    _attr_temperature_unit = TEMP_CELSIUS
+    _attr_preset_modes = [PRESET_AUTO, PRESET_DAY, PRESET_NIGHT]
+
+    def __init__(self, coordinator: Alpha2BaseCoordinator, heat_area_id: str) -> None:
+        """Initialize Alpha2 ClimateEntity."""
+        super().__init__(coordinator)
+        self.heat_area_id = heat_area_id
+
+    @property
+    def name(self) -> str:
+        """Return the name of the climate device."""
+        return self.coordinator.data[self.heat_area_id]["HEATAREA_NAME"]
+
+    @property
+    def min_temp(self) -> float:
+        """Return the minimum temperature."""
+        return float(self.coordinator.data[self.heat_area_id].get("T_TARGET_MIN", 0.0))
+
+    @property
+    def max_temp(self) -> float:
+        """Return the maximum temperature."""
+        return float(self.coordinator.data[self.heat_area_id].get("T_TARGET_MAX", 30.0))
+
+    @property
+    def current_temperature(self) -> float:
+        """Return the current temperature."""
+        return float(self.coordinator.data[self.heat_area_id].get("T_ACTUAL", 0.0))
+
+    @property
+    def hvac_mode(self) -> str:
+        """Return current hvac mode."""
+        if self.coordinator.get_cooling():
+            return HVAC_MODE_COOL
+        return HVAC_MODE_HEAT
+
+    async def async_set_hvac_mode(self, hvac_mode: str) -> None:
+        """Set new target hvac mode."""
+        await self.coordinator.async_set_cooling(hvac_mode == HVAC_MODE_COOL)
+
+    @property
+    def hvac_action(self) -> str:
+        """Return the current running hvac operation."""
+        if not self.coordinator.data[self.heat_area_id]["_HEATCTRL_STATE"]:
+            return CURRENT_HVAC_IDLE
+        if self.coordinator.get_cooling():
+            return CURRENT_HVAC_COOL
+        return CURRENT_HVAC_HEAT
+
+    @property
+    def target_temperature(self) -> float:
+        """Return the temperature we try to reach."""
+        return float(self.coordinator.data[self.heat_area_id].get("T_TARGET", 0.0))
+
+    async def async_set_temperature(self, **kwargs) -> None:
+        """Set new target temperatures."""
+        target_temperature = kwargs.get(ATTR_TEMPERATURE)
+        if target_temperature is None:
+            return
+
+        await self.coordinator.async_set_target_temperature(
+            self.heat_area_id, target_temperature
+        )
+
+    @property
+    def preset_mode(self) -> str:
+        """Return the current preset mode."""
+        if self.coordinator.data[self.heat_area_id]["HEATAREA_MODE"] == 1:
+            return PRESET_DAY
+        if self.coordinator.data[self.heat_area_id]["HEATAREA_MODE"] == 2:
+            return PRESET_NIGHT
+        return PRESET_AUTO
+
+    async def async_set_preset_mode(self, preset_mode: str) -> None:
+        """Set new operation mode."""
+        heat_area_mode = 0
+        if preset_mode == PRESET_DAY:
+            heat_area_mode = 1
+        elif preset_mode == PRESET_NIGHT:
+            heat_area_mode = 2
+
+        await self.coordinator.async_set_heat_area_mode(
+            self.heat_area_id, heat_area_mode
+        )
diff --git a/homeassistant/components/moehlenhoff_alpha2/config_flow.py b/homeassistant/components/moehlenhoff_alpha2/config_flow.py
new file mode 100644
index 00000000000..cafdca040b3
--- /dev/null
+++ b/homeassistant/components/moehlenhoff_alpha2/config_flow.py
@@ -0,0 +1,55 @@
+"""Alpha2 config flow."""
+import asyncio
+import logging
+
+import aiohttp
+from moehlenhoff_alpha2 import Alpha2Base
+import voluptuous as vol
+
+from homeassistant import config_entries
+
+from .const import DOMAIN
+
+_LOGGER = logging.getLogger(__name__)
+
+DATA_SCHEMA = vol.Schema({vol.Required("host"): str})
+
+
+async def validate_input(data):
+    """Validate the user input allows us to connect.
+
+    Data has the keys from DATA_SCHEMA with values provided by the user.
+    """
+
+    base = Alpha2Base(data["host"])
+    try:
+        await base.update_data()
+    except (aiohttp.client_exceptions.ClientConnectorError, asyncio.TimeoutError):
+        return {"error": "cannot_connect"}
+    except Exception:  # pylint: disable=broad-except
+        _LOGGER.exception("Unexpected exception")
+        return {"error": "unknown"}
+
+    # Return info that you want to store in the config entry.
+    return {"title": base.name}
+
+
+class Alpha2BaseConfigFlow(config_entries.ConfigFlow, domain=DOMAIN):
+    """Möhlenhoff Alpha2 config flow."""
+
+    VERSION = 1
+
+    async def async_step_user(self, user_input=None):
+        """Handle a flow initialized by the user."""
+        errors = {}
+        if user_input is not None:
+            self._async_abort_entries_match({"host": user_input["host"]})
+            result = await validate_input(user_input)
+            if result.get("error"):
+                errors["base"] = result["error"]
+            else:
+                return self.async_create_entry(title=result["title"], data=user_input)
+
+        return self.async_show_form(
+            step_id="user", data_schema=DATA_SCHEMA, errors=errors
+        )
diff --git a/homeassistant/components/moehlenhoff_alpha2/const.py b/homeassistant/components/moehlenhoff_alpha2/const.py
new file mode 100644
index 00000000000..268936982bd
--- /dev/null
+++ b/homeassistant/components/moehlenhoff_alpha2/const.py
@@ -0,0 +1,6 @@
+"""Constants for the Alpha2 integration."""
+
+DOMAIN = "moehlenhoff_alpha2"
+PRESET_AUTO = "auto"
+PRESET_DAY = "day"
+PRESET_NIGHT = "night"
diff --git a/homeassistant/components/moehlenhoff_alpha2/manifest.json b/homeassistant/components/moehlenhoff_alpha2/manifest.json
new file mode 100644
index 00000000000..b755b28f826
--- /dev/null
+++ b/homeassistant/components/moehlenhoff_alpha2/manifest.json
@@ -0,0 +1,11 @@
+{
+  "domain": "moehlenhoff_alpha2",
+  "name": "Möhlenhoff Alpha 2",
+  "config_flow": true,
+  "documentation": "https://www.home-assistant.io/integrations/moehlenhoff_alpha2",
+  "requirements": ["moehlenhoff-alpha2==1.1.2"],
+  "iot_class": "local_push",
+  "codeowners": [
+    "@j-a-n"
+  ]
+}
diff --git a/homeassistant/components/moehlenhoff_alpha2/strings.json b/homeassistant/components/moehlenhoff_alpha2/strings.json
new file mode 100644
index 00000000000..3347b2f318c
--- /dev/null
+++ b/homeassistant/components/moehlenhoff_alpha2/strings.json
@@ -0,0 +1,19 @@
+{
+  "title": "Möhlenhoff Alpha2",
+  "config": {
+    "step": {
+      "user": {
+        "data": {
+          "host": "[%key:common::config_flow::data::host%]"
+        }
+      }
+    },
+    "error": {
+      "cannot_connect": "[%key:common::config_flow::error::cannot_connect%]",
+      "unknown": "[%key:common::config_flow::error::unknown%]"
+    },
+    "abort": {
+      "already_configured": "[%key:common::config_flow::abort::already_configured_device%]"
+    }
+  }
+}
diff --git a/homeassistant/generated/config_flows.py b/homeassistant/generated/config_flows.py
index 2aab7c81481..be18826bedb 100644
--- a/homeassistant/generated/config_flows.py
+++ b/homeassistant/generated/config_flows.py
@@ -199,6 +199,7 @@ FLOWS = [
     "mobile_app",
     "modem_callerid",
     "modern_forms",
+    "moehlenhoff_alpha2",
     "monoprice",
     "motion_blinds",
     "motioneye",
diff --git a/requirements_all.txt b/requirements_all.txt
index 5fa50cde842..01011b048b7 100644
--- a/requirements_all.txt
+++ b/requirements_all.txt
@@ -1048,6 +1048,9 @@ minio==5.0.10
 # homeassistant.components.mitemp_bt
 mitemp_bt==0.0.5
 
+# homeassistant.components.moehlenhoff_alpha2
+moehlenhoff-alpha2==1.1.2
+
 # homeassistant.components.motion_blinds
 motionblinds==0.5.11
 
diff --git a/requirements_test_all.txt b/requirements_test_all.txt
index 4a74f1de59c..8f57bc2b05e 100644
--- a/requirements_test_all.txt
+++ b/requirements_test_all.txt
@@ -657,6 +657,9 @@ millheater==0.9.0
 # homeassistant.components.minio
 minio==5.0.10
 
+# homeassistant.components.moehlenhoff_alpha2
+moehlenhoff-alpha2==1.1.2
+
 # homeassistant.components.motion_blinds
 motionblinds==0.5.11
 
diff --git a/tests/components/moehlenhoff_alpha2/__init__.py b/tests/components/moehlenhoff_alpha2/__init__.py
new file mode 100644
index 00000000000..76bd1fd00aa
--- /dev/null
+++ b/tests/components/moehlenhoff_alpha2/__init__.py
@@ -0,0 +1 @@
+"""Tests for the moehlenhoff_alpha2 integration."""
diff --git a/tests/components/moehlenhoff_alpha2/test_config_flow.py b/tests/components/moehlenhoff_alpha2/test_config_flow.py
new file mode 100644
index 00000000000..ccfa98718e5
--- /dev/null
+++ b/tests/components/moehlenhoff_alpha2/test_config_flow.py
@@ -0,0 +1,106 @@
+"""Test the moehlenhoff_alpha2 config flow."""
+import asyncio
+from unittest.mock import patch
+
+from homeassistant import config_entries
+from homeassistant.components.moehlenhoff_alpha2.const import DOMAIN
+from homeassistant.core import HomeAssistant
+from homeassistant.data_entry_flow import (
+    RESULT_TYPE_ABORT,
+    RESULT_TYPE_CREATE_ENTRY,
+    RESULT_TYPE_FORM,
+)
+
+from tests.common import MockConfigEntry
+
+MOCK_BASE_ID = "fake-base-id"
+MOCK_BASE_NAME = "fake-base-name"
+MOCK_BASE_HOST = "fake-base-host"
+
+
+async def mock_update_data(self):
+    """Mock moehlenhoff_alpha2.Alpha2Base.update_data."""
+    self.static_data = {
+        "Devices": {
+            "Device": {"ID": MOCK_BASE_ID, "NAME": MOCK_BASE_NAME, "HEATAREA": []}
+        }
+    }
+
+
+async def test_form(hass: HomeAssistant) -> None:
+    """Test we get the form."""
+    result = await hass.config_entries.flow.async_init(
+        DOMAIN,
+        context={"source": config_entries.SOURCE_USER},
+    )
+    assert result["type"] == RESULT_TYPE_FORM
+    assert not result["errors"]
+
+    with patch("moehlenhoff_alpha2.Alpha2Base.update_data", mock_update_data), patch(
+        "homeassistant.components.moehlenhoff_alpha2.async_setup_entry",
+        return_value=True,
+    ) as mock_setup_entry:
+        result2 = await hass.config_entries.flow.async_configure(
+            flow_id=result["flow_id"],
+            user_input={"host": MOCK_BASE_HOST},
+        )
+        await hass.async_block_till_done()
+
+    assert result2["type"] == RESULT_TYPE_CREATE_ENTRY
+    assert result2["title"] == MOCK_BASE_NAME
+    assert result2["data"] == {"host": MOCK_BASE_HOST}
+    assert len(mock_setup_entry.mock_calls) == 1
+
+
+async def test_form_duplicate_error(hass: HomeAssistant) -> None:
+    """Test that errors are shown when duplicates are added."""
+    config_entry = MockConfigEntry(
+        domain=DOMAIN,
+        data={"host": MOCK_BASE_HOST},
+        source=config_entries.SOURCE_USER,
+    )
+    config_entry.add_to_hass(hass)
+
+    assert config_entry.data["host"] == MOCK_BASE_HOST
+
+    with patch("moehlenhoff_alpha2.Alpha2Base.update_data", mock_update_data):
+
+        result = await hass.config_entries.flow.async_init(
+            DOMAIN,
+            data={"host": MOCK_BASE_HOST},
+            context={"source": config_entries.SOURCE_USER},
+        )
+        assert result["type"] == RESULT_TYPE_ABORT
+        assert result["reason"] == "already_configured"
+
+
+async def test_form_cannot_connect_error(hass: HomeAssistant) -> None:
+    """Test connection error."""
+    result = await hass.config_entries.flow.async_init(
+        DOMAIN, context={"source": config_entries.SOURCE_USER}
+    )
+    with patch(
+        "moehlenhoff_alpha2.Alpha2Base.update_data", side_effect=asyncio.TimeoutError
+    ):
+        result2 = await hass.config_entries.flow.async_configure(
+            flow_id=result["flow_id"],
+            user_input={"host": MOCK_BASE_HOST},
+        )
+
+        assert result2["type"] == RESULT_TYPE_FORM
+        assert result2["errors"] == {"base": "cannot_connect"}
+
+
+async def test_form_unexpected_error(hass: HomeAssistant) -> None:
+    """Test unexpected error."""
+    result = await hass.config_entries.flow.async_init(
+        DOMAIN, context={"source": config_entries.SOURCE_USER}
+    )
+    with patch("moehlenhoff_alpha2.Alpha2Base.update_data", side_effect=Exception):
+        result2 = await hass.config_entries.flow.async_configure(
+            flow_id=result["flow_id"],
+            user_input={"host": MOCK_BASE_HOST},
+        )
+
+        assert result2["type"] == RESULT_TYPE_FORM
+        assert result2["errors"] == {"base": "unknown"}