diff --git a/homeassistant/components/airnow/__init__.py b/homeassistant/components/airnow/__init__.py
index 8fe2291d3b3..d7caaa120fc 100644
--- a/homeassistant/components/airnow/__init__.py
+++ b/homeassistant/components/airnow/__init__.py
@@ -11,6 +11,7 @@ from homeassistant.const import (
     Platform,
 )
 from homeassistant.core import HomeAssistant
+from homeassistant.helpers import device_registry as dr, entity_registry as er
 from homeassistant.helpers.aiohttp_client import async_get_clientsession
 
 from .const import DOMAIN
@@ -50,6 +51,20 @@ async def async_setup_entry(hass: HomeAssistant, entry: ConfigEntry) -> bool:
 
     await hass.config_entries.async_forward_entry_setups(entry, PLATFORMS)
 
+    # Clean up unused device entries with no entities
+    device_registry = dr.async_get(hass)
+    entity_registry = er.async_get(hass)
+
+    device_entries = dr.async_entries_for_config_entry(
+        device_registry, config_entry_id=entry.entry_id
+    )
+    for dev in device_entries:
+        dev_entities = er.async_entries_for_device(
+            entity_registry, dev.id, include_disabled_entities=True
+        )
+        if not dev_entities:
+            device_registry.async_remove_device(dev.id)
+
     return True
 
 
diff --git a/homeassistant/components/airnow/sensor.py b/homeassistant/components/airnow/sensor.py
index f9d35d50810..c6ab27a8497 100644
--- a/homeassistant/components/airnow/sensor.py
+++ b/homeassistant/components/airnow/sensor.py
@@ -148,13 +148,14 @@ class AirNowSensor(CoordinatorEntity[AirNowDataUpdateCoordinator], SensorEntity)
     ) -> None:
         """Initialize."""
         super().__init__(coordinator)
+
+        _device_id = f"{coordinator.latitude}-{coordinator.longitude}"
+
         self.entity_description = description
-        self._attr_unique_id = (
-            f"{coordinator.latitude}-{coordinator.longitude}-{description.key.lower()}"
-        )
+        self._attr_unique_id = f"{_device_id}-{description.key.lower()}"
         self._attr_device_info = DeviceInfo(
             entry_type=DeviceEntryType.SERVICE,
-            identifiers={(DOMAIN, self._attr_unique_id)},
+            identifiers={(DOMAIN, _device_id)},
             manufacturer=DEFAULT_NAME,
             name=DEFAULT_NAME,
         )