diff --git a/.github/workflows/ci.yaml b/.github/workflows/ci.yaml
index 3cecb157d07..a04e815af7f 100644
--- a/.github/workflows/ci.yaml
+++ b/.github/workflows/ci.yaml
@@ -580,7 +580,7 @@ jobs:
 
           python -m venv venv
           . venv/bin/activate
-          pip install -U "pip<20.3" "setuptools<58" wheel
+          pip install -U "pip<20.3" setuptools wheel
           pip install -r requirements_all.txt
           pip install -r requirements_test.txt
           pip install -e .
diff --git a/homeassistant/components/syncthru/__init__.py b/homeassistant/components/syncthru/__init__.py
index c422bfa6f33..ef3e8c4419d 100644
--- a/homeassistant/components/syncthru/__init__.py
+++ b/homeassistant/components/syncthru/__init__.py
@@ -5,14 +5,13 @@ from datetime import timedelta
 import logging
 
 import async_timeout
-from pysyncthru import SyncThru
+from pysyncthru import ConnectionMode, SyncThru, SyncThruAPINotSupported
 
 from homeassistant.components.binary_sensor import DOMAIN as BINARY_SENSOR_DOMAIN
 from homeassistant.components.sensor import DOMAIN as SENSOR_DOMAIN
 from homeassistant.config_entries import ConfigEntry
 from homeassistant.const import CONF_URL
 from homeassistant.core import HomeAssistant
-from homeassistant.exceptions import ConfigEntryNotReady
 from homeassistant.helpers import aiohttp_client, device_registry as dr
 from homeassistant.helpers.update_coordinator import DataUpdateCoordinator, UpdateFailed
 
@@ -28,22 +27,29 @@ async def async_setup_entry(hass: HomeAssistant, entry: ConfigEntry) -> bool:
 
     session = aiohttp_client.async_get_clientsession(hass)
     hass.data.setdefault(DOMAIN, {})
-    printer = SyncThru(entry.data[CONF_URL], session)
+    printer = SyncThru(
+        entry.data[CONF_URL], session, connection_mode=ConnectionMode.API
+    )
 
     async def async_update_data() -> SyncThru:
         """Fetch data from the printer."""
         try:
             async with async_timeout.timeout(10):
                 await printer.update()
-        except ValueError as value_error:
+        except SyncThruAPINotSupported as api_error:
             # if an exception is thrown, printer does not support syncthru
-            raise UpdateFailed(
-                f"Configured printer at {printer.url} does not respond. "
-                "Please make sure it supports SyncThru and check your configuration."
-            ) from value_error
+            _LOGGER.info(
+                "Configured printer at %s does not provide SyncThru JSON API",
+                printer.url,
+                exc_info=api_error,
+            )
+            raise api_error
         else:
+            # if the printer is offline, we raise an UpdateFailed
             if printer.is_unknown_state():
-                raise ConfigEntryNotReady
+                raise UpdateFailed(
+                    f"Configured printer at {printer.url} does not respond."
+                )
             return printer
 
     coordinator: DataUpdateCoordinator = DataUpdateCoordinator(
@@ -55,6 +61,10 @@ async def async_setup_entry(hass: HomeAssistant, entry: ConfigEntry) -> bool:
     )
     hass.data[DOMAIN][entry.entry_id] = coordinator
     await coordinator.async_config_entry_first_refresh()
+    if isinstance(coordinator.last_exception, SyncThruAPINotSupported):
+        # this means that the printer does not support the syncthru JSON API
+        # and the config should simply be discarded
+        return False
 
     device_registry = await dr.async_get_registry(hass)
     device_registry.async_get_or_create(
diff --git a/homeassistant/components/syncthru/config_flow.py b/homeassistant/components/syncthru/config_flow.py
index 31bf8c97edc..db822f650dc 100644
--- a/homeassistant/components/syncthru/config_flow.py
+++ b/homeassistant/components/syncthru/config_flow.py
@@ -3,7 +3,7 @@
 import re
 from urllib.parse import urlparse
 
-from pysyncthru import SyncThru
+from pysyncthru import ConnectionMode, SyncThru, SyncThruAPINotSupported
 from url_normalize import url_normalize
 import voluptuous as vol
 
@@ -109,7 +109,9 @@ class SyncThruConfigFlow(config_entries.ConfigFlow, domain=DOMAIN):
                 break
 
         session = aiohttp_client.async_get_clientsession(self.hass)
-        printer = SyncThru(user_input[CONF_URL], session)
+        printer = SyncThru(
+            user_input[CONF_URL], session, connection_mode=ConnectionMode.API
+        )
         errors = {}
         try:
             await printer.update()
@@ -117,7 +119,7 @@ class SyncThruConfigFlow(config_entries.ConfigFlow, domain=DOMAIN):
                 user_input[CONF_NAME] = DEFAULT_NAME_TEMPLATE.format(
                     printer.model() or DEFAULT_MODEL
                 )
-        except ValueError:
+        except SyncThruAPINotSupported:
             errors[CONF_URL] = "syncthru_not_supported"
         else:
             if printer.is_unknown_state():
diff --git a/homeassistant/components/syncthru/manifest.json b/homeassistant/components/syncthru/manifest.json
index 9fd3c2afe06..37b7ed311cb 100644
--- a/homeassistant/components/syncthru/manifest.json
+++ b/homeassistant/components/syncthru/manifest.json
@@ -3,7 +3,7 @@
   "name": "Samsung SyncThru Printer",
   "documentation": "https://www.home-assistant.io/integrations/syncthru",
   "config_flow": true,
-  "requirements": ["pysyncthru==0.7.3", "url-normalize==1.4.1"],
+  "requirements": ["pysyncthru==0.7.10", "url-normalize==1.4.1"],
   "ssdp": [
     {
       "deviceType": "urn:schemas-upnp-org:device:Printer:1",
diff --git a/requirements_all.txt b/requirements_all.txt
index 6b396e0609f..1fbc0b445e6 100644
--- a/requirements_all.txt
+++ b/requirements_all.txt
@@ -1835,7 +1835,7 @@ pystiebeleltron==0.0.1.dev2
 pysuez==0.1.19
 
 # homeassistant.components.syncthru
-pysyncthru==0.7.3
+pysyncthru==0.7.10
 
 # homeassistant.components.tankerkoenig
 pytankerkoenig==0.0.6
diff --git a/requirements_test_all.txt b/requirements_test_all.txt
index 7f5cd0a7a37..62b4ac0cbef 100644
--- a/requirements_test_all.txt
+++ b/requirements_test_all.txt
@@ -1082,7 +1082,7 @@ pyspcwebgw==0.4.0
 pysqueezebox==0.5.5
 
 # homeassistant.components.syncthru
-pysyncthru==0.7.3
+pysyncthru==0.7.10
 
 # homeassistant.components.ecobee
 python-ecobee-api==0.2.11
diff --git a/tests/components/syncthru/test_config_flow.py b/tests/components/syncthru/test_config_flow.py
index 70e8a80ad0f..61bc2992f52 100644
--- a/tests/components/syncthru/test_config_flow.py
+++ b/tests/components/syncthru/test_config_flow.py
@@ -3,6 +3,8 @@
 import re
 from unittest.mock import patch
 
+from pysyncthru import SyncThruAPINotSupported
+
 from homeassistant import config_entries, data_entry_flow, setup
 from homeassistant.components import ssdp
 from homeassistant.components.syncthru.config_flow import SyncThru
@@ -71,7 +73,7 @@ async def test_already_configured_by_url(hass, aioclient_mock):
 
 async def test_syncthru_not_supported(hass):
     """Test we show user form on unsupported device."""
-    with patch.object(SyncThru, "update", side_effect=ValueError):
+    with patch.object(SyncThru, "update", side_effect=SyncThruAPINotSupported):
         result = await hass.config_entries.flow.async_init(
             DOMAIN,
             context={"source": config_entries.SOURCE_USER},