diff --git a/homeassistant/components/hassio/http.py b/homeassistant/components/hassio/http.py
index 4a0def62b4d..fe01cbe3197 100644
--- a/homeassistant/components/hassio/http.py
+++ b/homeassistant/components/hassio/http.py
@@ -10,6 +10,7 @@ import aiohttp
 from aiohttp import web
 from aiohttp.client import ClientTimeout
 from aiohttp.hdrs import (
+    CACHE_CONTROL,
     CONTENT_ENCODING,
     CONTENT_LENGTH,
     CONTENT_TYPE,
@@ -51,6 +52,8 @@ NO_AUTH = re.compile(
     r"^(?:" r"|app/.*" r"|addons/[^/]+/logo" r"|addons/[^/]+/icon" r")$"
 )
 
+NO_STORE = re.compile(r"^(?:" r"|app/entrypoint.js" r")$")
+
 
 class HassIOView(HomeAssistantView):
     """Hass.io view to handle base part."""
@@ -104,7 +107,7 @@ class HassIOView(HomeAssistantView):
 
             # Stream response
             response = web.StreamResponse(
-                status=client.status, headers=_response_header(client)
+                status=client.status, headers=_response_header(client, path)
             )
             response.content_type = client.content_type
 
@@ -139,7 +142,7 @@ def _init_header(request: web.Request) -> dict[str, str]:
     return headers
 
 
-def _response_header(response: aiohttp.ClientResponse) -> dict[str, str]:
+def _response_header(response: aiohttp.ClientResponse, path: str) -> dict[str, str]:
     """Create response header."""
     headers = {}
 
@@ -153,6 +156,9 @@ def _response_header(response: aiohttp.ClientResponse) -> dict[str, str]:
             continue
         headers[name] = value
 
+    if NO_STORE.match(path):
+        headers[CACHE_CONTROL] = "no-store, max-age=0"
+
     return headers
 
 
diff --git a/tests/components/hassio/test_http.py b/tests/components/hassio/test_http.py
index f411b465774..16121393170 100644
--- a/tests/components/hassio/test_http.py
+++ b/tests/components/hassio/test_http.py
@@ -185,3 +185,21 @@ async def test_stream(hassio_client, aioclient_mock):
     aioclient_mock.get("http://127.0.0.1/test")
     await hassio_client.get("/api/hassio/test", data="test")
     assert isinstance(aioclient_mock.mock_calls[-1][2], StreamReader)
+
+
+async def test_entrypoint_cache_control(hassio_client, aioclient_mock):
+    """Test that we return cache control for requests to the entrypoint only."""
+    aioclient_mock.get("http://127.0.0.1/app/entrypoint.js")
+    aioclient_mock.get("http://127.0.0.1/app/entrypoint.fdhkusd8y43r.js")
+
+    resp1 = await hassio_client.get("/api/hassio/app/entrypoint.js")
+    resp2 = await hassio_client.get("/api/hassio/app/entrypoint.fdhkusd8y43r.js")
+
+    # Check we got right response
+    assert resp1.status == 200
+    assert resp2.status == 200
+
+    assert len(aioclient_mock.mock_calls) == 2
+    assert resp1.headers["Cache-Control"] == "no-store, max-age=0"
+
+    assert "Cache-Control" not in resp2.headers