diff --git a/homeassistant/components/synology_dsm/config_flow.py b/homeassistant/components/synology_dsm/config_flow.py
index ed0ee8e9125..a40dfd87744 100644
--- a/homeassistant/components/synology_dsm/config_flow.py
+++ b/homeassistant/components/synology_dsm/config_flow.py
@@ -1,6 +1,7 @@
 """Config flow to configure the Synology DSM integration."""
 from __future__ import annotations
 
+from ipaddress import ip_address
 import logging
 from typing import Any
 from urllib.parse import urlparse
@@ -92,6 +93,14 @@ def _ordered_shared_schema(
     }
 
 
+def _is_valid_ip(text: str) -> bool:
+    try:
+        ip_address(text)
+    except ValueError:
+        return False
+    return True
+
+
 class SynologyDSMFlowHandler(ConfigFlow, domain=DOMAIN):
     """Handle a config flow."""
 
@@ -245,7 +254,17 @@ class SynologyDSMFlowHandler(ConfigFlow, domain=DOMAIN):
         if not existing_entry:
             self._abort_if_unique_id_configured()
 
-        if existing_entry and existing_entry.data[CONF_HOST] != parsed_url.hostname:
+        fqdn_with_ssl_verification = (
+            existing_entry
+            and not _is_valid_ip(existing_entry.data[CONF_HOST])
+            and existing_entry.data[CONF_VERIFY_SSL]
+        )
+
+        if (
+            existing_entry
+            and existing_entry.data[CONF_HOST] != parsed_url.hostname
+            and not fqdn_with_ssl_verification
+        ):
             _LOGGER.debug(
                 "Update host from '%s' to '%s' for NAS '%s' via SSDP discovery",
                 existing_entry.data[CONF_HOST],
diff --git a/tests/components/synology_dsm/test_config_flow.py b/tests/components/synology_dsm/test_config_flow.py
index cc761a4b06a..435ed3bdb4b 100644
--- a/tests/components/synology_dsm/test_config_flow.py
+++ b/tests/components/synology_dsm/test_config_flow.py
@@ -423,6 +423,7 @@ async def test_reconfig_ssdp(hass: HomeAssistant, service: MagicMock):
         domain=DOMAIN,
         data={
             CONF_HOST: "wrong_host",
+            CONF_VERIFY_SSL: VERIFY_SSL,
             CONF_USERNAME: USERNAME,
             CONF_PASSWORD: PASSWORD,
             CONF_MAC: MACS,
@@ -443,6 +444,34 @@ async def test_reconfig_ssdp(hass: HomeAssistant, service: MagicMock):
     assert result["reason"] == "reconfigure_successful"
 
 
+async def test_skip_reconfig_ssdp(hass: HomeAssistant, service: MagicMock):
+    """Test re-configuration of already existing entry by ssdp."""
+
+    MockConfigEntry(
+        domain=DOMAIN,
+        data={
+            CONF_HOST: "wrong_host",
+            CONF_VERIFY_SSL: True,
+            CONF_USERNAME: USERNAME,
+            CONF_PASSWORD: PASSWORD,
+            CONF_MAC: MACS,
+        },
+        unique_id=SERIAL,
+    ).add_to_hass(hass)
+
+    result = await hass.config_entries.flow.async_init(
+        DOMAIN,
+        context={"source": SOURCE_SSDP},
+        data={
+            ssdp.ATTR_SSDP_LOCATION: "http://192.168.1.5:5000",
+            ssdp.ATTR_UPNP_FRIENDLY_NAME: "mydsm",
+            ssdp.ATTR_UPNP_SERIAL: "001132XXXX59",  # Existing in MACS[0], but SSDP does not have `-`
+        },
+    )
+    assert result["type"] == data_entry_flow.RESULT_TYPE_ABORT
+    assert result["reason"] == "already_configured"
+
+
 async def test_existing_ssdp(hass: HomeAssistant, service: MagicMock):
     """Test abort of already existing entry by ssdp."""
 
@@ -450,6 +479,7 @@ async def test_existing_ssdp(hass: HomeAssistant, service: MagicMock):
         domain=DOMAIN,
         data={
             CONF_HOST: "192.168.1.5",
+            CONF_VERIFY_SSL: VERIFY_SSL,
             CONF_USERNAME: USERNAME,
             CONF_PASSWORD: PASSWORD,
             CONF_MAC: MACS,