diff --git a/.pre-commit-config.yaml b/.pre-commit-config.yaml
index 17575ebe375..256a0d7d155 100644
--- a/.pre-commit-config.yaml
+++ b/.pre-commit-config.yaml
@@ -107,7 +107,7 @@ repos:
         pass_filenames: false
         language: script
         types: [text]
-        files: ^(homeassistant/.+/manifest\.json|setup\.py|\.pre-commit-config\.yaml|script/gen_requirements_all\.py)$
+        files: ^(homeassistant/.+/manifest\.json|setup\.cfg|\.pre-commit-config\.yaml|script/gen_requirements_all\.py)$
       - id: hassfest
         name: hassfest
         entry: script/run-in-env.sh python3 -m script.hassfest
diff --git a/script/gen_requirements_all.py b/script/gen_requirements_all.py
index ce2178288a0..872f2d0c7a8 100755
--- a/script/gen_requirements_all.py
+++ b/script/gen_requirements_all.py
@@ -1,5 +1,6 @@
 #!/usr/bin/env python3
 """Generate an updated requirements_all.txt."""
+import configparser
 import difflib
 import importlib
 import os
@@ -167,10 +168,9 @@ def explore_module(package, explore_children):
 
 def core_requirements():
     """Gather core requirements out of setup.py."""
-    reqs_raw = re.search(
-        r"REQUIRES = \[(.*?)\]", Path("setup.py").read_text(), re.S
-    ).group(1)
-    return [x[1] for x in re.findall(r"(['\"])(.*?)\1", reqs_raw)]
+    parser = configparser.ConfigParser()
+    parser.read("setup.cfg")
+    return parser["options"]["install_requires"].strip().split("\n")
 
 
 def gather_recursive_requirements(domain, seen=None):
diff --git a/setup.cfg b/setup.cfg
index f285902985c..4b226b4402c 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -14,6 +14,34 @@ classifier =
     Programming Language :: Python :: 3.9
     Topic :: Home Automation
 
+[options]
+install_requires =
+    aiohttp==3.8.1
+    astral==2.2
+    async_timeout==4.0.2
+    attrs==21.2.0
+    atomicwrites==1.4.0
+    awesomeversion==22.1.0
+    bcrypt==3.1.7
+    certifi>=2021.5.30
+    ciso8601==2.2.0
+    # When bumping httpx, please check the version pins of
+    # httpcore, anyio, and h11 in gen_requirements_all
+    httpx==0.21.3
+    ifaddr==0.1.7
+    jinja2==3.0.3
+    PyJWT==2.1.0
+    # PyJWT has loose dependency. We want the latest one.
+    cryptography==35.0.0
+    pip>=8.0.3,<20.3
+    python-slugify==4.0.1
+    pyyaml==6.0
+    requests==2.27.1
+    typing-extensions>=3.10.0.2,<5.0
+    voluptuous==0.12.2
+    voluptuous-serialize==2.5.0
+    yarl==1.7.2
+
 [flake8]
 exclude = .venv,.git,.tox,docs,venv,bin,lib,deps,build
 max-complexity = 25
diff --git a/setup.py b/setup.py
index efcf61b85fc..c6f3f1fb02f 100755
--- a/setup.py
+++ b/setup.py
@@ -31,34 +31,6 @@ PROJECT_URLS = {
 
 PACKAGES = find_packages(exclude=["tests", "tests.*"])
 
-REQUIRES = [
-    "aiohttp==3.8.1",
-    "astral==2.2",
-    "async_timeout==4.0.2",
-    "attrs==21.2.0",
-    "atomicwrites==1.4.0",
-    "awesomeversion==22.1.0",
-    "bcrypt==3.1.7",
-    "certifi>=2021.5.30",
-    "ciso8601==2.2.0",
-    # When bumping httpx, please check the version pins of
-    # httpcore, anyio, and h11 in gen_requirements_all
-    "httpx==0.21.3",
-    "ifaddr==0.1.7",
-    "jinja2==3.0.3",
-    "PyJWT==2.1.0",
-    # PyJWT has loose dependency. We want the latest one.
-    "cryptography==35.0.0",
-    "pip>=8.0.3,<20.3",
-    "python-slugify==4.0.1",
-    "pyyaml==6.0",
-    "requests==2.27.1",
-    "typing-extensions>=3.10.0.2,<5.0",
-    "voluptuous==0.12.2",
-    "voluptuous-serialize==2.5.0",
-    "yarl==1.7.2",
-]
-
 MIN_PY_VERSION = ".".join(map(str, hass_const.REQUIRED_PYTHON_VER))
 
 setup(
@@ -72,7 +44,6 @@ setup(
     packages=PACKAGES,
     include_package_data=True,
     zip_safe=False,
-    install_requires=REQUIRES,
     python_requires=f">={MIN_PY_VERSION}",
     test_suite="tests",
     entry_points={"console_scripts": ["hass = homeassistant.__main__:main"]},