diff --git a/.coveragerc b/.coveragerc
index ccbdaa9c6fa..1fdabeff103 100644
--- a/.coveragerc
+++ b/.coveragerc
@@ -703,7 +703,6 @@ omit =
     homeassistant/components/prowl/notify.py
     homeassistant/components/proxmoxve/*
     homeassistant/components/proxy/camera.py
-    homeassistant/components/ptvsd/*
     homeassistant/components/pulseaudio_loopback/switch.py
     homeassistant/components/pushbullet/notify.py
     homeassistant/components/pushbullet/sensor.py
diff --git a/CODEOWNERS b/CODEOWNERS
index 7b874bb0ebf..1ec8f6f30f1 100644
--- a/CODEOWNERS
+++ b/CODEOWNERS
@@ -352,7 +352,6 @@ homeassistant/components/progettihwsw/* @ardaseremet
 homeassistant/components/prometheus/* @knyar
 homeassistant/components/proxmoxve/* @k4ds3 @jhollowe
 homeassistant/components/ps4/* @ktnrg45
-homeassistant/components/ptvsd/* @swamp-ig
 homeassistant/components/push/* @dgomes
 homeassistant/components/pvoutput/* @fabaff
 homeassistant/components/pvpc_hourly_pricing/* @azogue
diff --git a/homeassistant/bootstrap.py b/homeassistant/bootstrap.py
index b68fc9d17ac..ff8ecfa0070 100644
--- a/homeassistant/bootstrap.py
+++ b/homeassistant/bootstrap.py
@@ -48,7 +48,7 @@ COOLDOWN_TIME = 60
 
 MAX_LOAD_CONCURRENTLY = 6
 
-DEBUGGER_INTEGRATIONS = {"debugpy", "ptvsd"}
+DEBUGGER_INTEGRATIONS = {"debugpy"}
 CORE_INTEGRATIONS = ("homeassistant", "persistent_notification")
 LOGGING_INTEGRATIONS = {
     # Set log levels
diff --git a/homeassistant/components/ptvsd/__init__.py b/homeassistant/components/ptvsd/__init__.py
deleted file mode 100644
index 258589084a0..00000000000
--- a/homeassistant/components/ptvsd/__init__.py
+++ /dev/null
@@ -1,70 +0,0 @@
-"""
-Enable ptvsd debugger to attach to HA.
-
-Attach ptvsd debugger by default to port 5678.
-"""
-
-from asyncio import Event
-import logging
-from threading import Thread
-
-import voluptuous as vol
-
-from homeassistant.const import CONF_HOST, CONF_PORT
-import homeassistant.helpers.config_validation as cv
-from homeassistant.helpers.typing import ConfigType, HomeAssistantType
-
-DOMAIN = "ptvsd"
-
-CONF_WAIT = "wait"
-
-_LOGGER = logging.getLogger(__name__)
-
-CONFIG_SCHEMA = vol.Schema(
-    {
-        DOMAIN: vol.Schema(
-            {
-                vol.Optional(CONF_HOST, default="0.0.0.0"): cv.string,
-                vol.Optional(CONF_PORT, default=5678): cv.port,
-                vol.Optional(CONF_WAIT, default=False): cv.boolean,
-            }
-        )
-    },
-    extra=vol.ALLOW_EXTRA,
-)
-
-
-async def async_setup(hass: HomeAssistantType, config: ConfigType):
-    """Set up ptvsd debugger."""
-    _LOGGER.warning(
-        "ptvsd is deprecated and will be removed in Home Assistant Core 0.120."
-        "The debugpy integration can be used as a full replacement for ptvsd"
-    )
-
-    # This is a local import, since importing this at the top, will cause
-    # ptvsd to hook into `sys.settrace`. So does `coverage` to generate
-    # coverage, resulting in a battle and incomplete code test coverage.
-    import ptvsd  # pylint: disable=import-outside-toplevel
-
-    conf = config[DOMAIN]
-    host = conf[CONF_HOST]
-    port = conf[CONF_PORT]
-
-    ptvsd.enable_attach((host, port))
-
-    wait = conf[CONF_WAIT]
-    if wait:
-        _LOGGER.warning("Waiting for ptvsd connection on %s:%s", host, port)
-        ready = Event()
-
-        def waitfor():
-            ptvsd.wait_for_attach()
-            hass.loop.call_soon_threadsafe(ready.set)
-
-        Thread(target=waitfor).start()
-
-        await ready.wait()
-    else:
-        _LOGGER.warning("Listening for ptvsd connection on %s:%s", host, port)
-
-    return True
diff --git a/homeassistant/components/ptvsd/manifest.json b/homeassistant/components/ptvsd/manifest.json
deleted file mode 100644
index 5feb04e92bb..00000000000
--- a/homeassistant/components/ptvsd/manifest.json
+++ /dev/null
@@ -1,7 +0,0 @@
-{
-  "domain": "ptvsd",
-  "name": "PTVSD - Python Tools for Visual Studio Debug Server",
-  "documentation": "https://www.home-assistant.io/integrations/ptvsd",
-  "requirements": ["ptvsd==4.3.2"],
-  "codeowners": ["@swamp-ig"]
-}
diff --git a/requirements_all.txt b/requirements_all.txt
index 940d2b96a89..4bef886080d 100644
--- a/requirements_all.txt
+++ b/requirements_all.txt
@@ -1170,9 +1170,6 @@ proxmoxer==1.1.1
 # homeassistant.components.systemmonitor
 psutil==5.8.0
 
-# homeassistant.components.ptvsd
-ptvsd==4.3.2
-
 # homeassistant.components.wink
 pubnubsub-handler==1.0.9
 
diff --git a/requirements_test_all.txt b/requirements_test_all.txt
index c7da734d3e9..6585308074a 100644
--- a/requirements_test_all.txt
+++ b/requirements_test_all.txt
@@ -587,9 +587,6 @@ progettihwsw==0.1.1
 # homeassistant.components.prometheus
 prometheus_client==0.7.1
 
-# homeassistant.components.ptvsd
-ptvsd==4.3.2
-
 # homeassistant.components.androidtv
 pure-python-adb[async]==0.3.0.dev0
 
diff --git a/tests/components/ptvsd/__init__py b/tests/components/ptvsd/__init__py
deleted file mode 100644
index e2a1a9ba0a6..00000000000
--- a/tests/components/ptvsd/__init__py
+++ /dev/null
@@ -1 +0,0 @@
-"""Tests for PTVSD Debugger"""
diff --git a/tests/components/ptvsd/test_ptvsd.py b/tests/components/ptvsd/test_ptvsd.py
deleted file mode 100644
index b3e408833dc..00000000000
--- a/tests/components/ptvsd/test_ptvsd.py
+++ /dev/null
@@ -1,48 +0,0 @@
-"""Tests for PTVSD Debugger."""
-
-from unittest.mock import AsyncMock, patch
-
-from pytest import mark
-
-from homeassistant.bootstrap import _async_set_up_integrations
-import homeassistant.components.ptvsd as ptvsd_component
-from homeassistant.setup import async_setup_component
-
-
-@mark.skip("causes code cover to fail")
-async def test_ptvsd(hass):
-    """Test loading ptvsd component."""
-    with patch("ptvsd.enable_attach") as attach:
-        with patch("ptvsd.wait_for_attach") as wait:
-            assert await async_setup_component(
-                hass, ptvsd_component.DOMAIN, {ptvsd_component.DOMAIN: {}}
-            )
-
-            attach.assert_called_once_with(("0.0.0.0", 5678))
-            assert wait.call_count == 0
-
-
-@mark.skip("causes code cover to fail")
-async def test_ptvsd_wait(hass):
-    """Test loading ptvsd component with wait."""
-    with patch("ptvsd.enable_attach") as attach:
-        with patch("ptvsd.wait_for_attach") as wait:
-            assert await async_setup_component(
-                hass,
-                ptvsd_component.DOMAIN,
-                {ptvsd_component.DOMAIN: {ptvsd_component.CONF_WAIT: True}},
-            )
-
-            attach.assert_called_once_with(("0.0.0.0", 5678))
-            assert wait.call_count == 1
-
-
-async def test_ptvsd_bootstrap(hass):
-    """Test loading ptvsd component with wait."""
-    config = {ptvsd_component.DOMAIN: {ptvsd_component.CONF_WAIT: True}}
-
-    with patch("homeassistant.components.ptvsd.async_setup", AsyncMock()) as setup_mock:
-        setup_mock.return_value = True
-        await _async_set_up_integrations(hass, config)
-
-        assert setup_mock.call_count == 1