diff --git a/homeassistant/components/compensation/manifest.json b/homeassistant/components/compensation/manifest.json
index caae9190bca..90fa6289b8d 100644
--- a/homeassistant/components/compensation/manifest.json
+++ b/homeassistant/components/compensation/manifest.json
@@ -4,5 +4,5 @@
   "codeowners": ["@Petro31"],
   "documentation": "https://www.home-assistant.io/integrations/compensation",
   "iot_class": "calculated",
-  "requirements": ["numpy==1.26.4"]
+  "requirements": ["numpy==2.1.2"]
 }
diff --git a/homeassistant/components/iqvia/manifest.json b/homeassistant/components/iqvia/manifest.json
index 6142fa1349e..d589c117edd 100644
--- a/homeassistant/components/iqvia/manifest.json
+++ b/homeassistant/components/iqvia/manifest.json
@@ -7,5 +7,5 @@
   "integration_type": "service",
   "iot_class": "cloud_polling",
   "loggers": ["pyiqvia"],
-  "requirements": ["numpy==1.26.4", "pyiqvia==2022.04.0"]
+  "requirements": ["numpy==2.1.2", "pyiqvia==2022.04.0"]
 }
diff --git a/homeassistant/components/stream/manifest.json b/homeassistant/components/stream/manifest.json
index 23494a06744..304ef5bbf62 100644
--- a/homeassistant/components/stream/manifest.json
+++ b/homeassistant/components/stream/manifest.json
@@ -7,5 +7,5 @@
   "integration_type": "system",
   "iot_class": "local_push",
   "quality_scale": "internal",
-  "requirements": ["PyTurboJPEG==1.7.5", "av==13.1.0", "numpy==1.26.4"]
+  "requirements": ["PyTurboJPEG==1.7.5", "av==13.1.0", "numpy==2.1.2"]
 }
diff --git a/homeassistant/components/tensorflow/manifest.json b/homeassistant/components/tensorflow/manifest.json
index 4f2b6f19285..906ce02f5b1 100644
--- a/homeassistant/components/tensorflow/manifest.json
+++ b/homeassistant/components/tensorflow/manifest.json
@@ -9,7 +9,7 @@
     "tensorflow==2.5.0",
     "tf-models-official==2.5.0",
     "pycocotools==2.0.6",
-    "numpy==1.26.4",
+    "numpy==2.1.2",
     "Pillow==10.4.0"
   ]
 }
diff --git a/homeassistant/components/trend/manifest.json b/homeassistant/components/trend/manifest.json
index 56b4b811171..b2f47738d4a 100644
--- a/homeassistant/components/trend/manifest.json
+++ b/homeassistant/components/trend/manifest.json
@@ -7,5 +7,5 @@
   "integration_type": "helper",
   "iot_class": "calculated",
   "quality_scale": "internal",
-  "requirements": ["numpy==1.26.4"]
+  "requirements": ["numpy==2.1.2"]
 }
diff --git a/homeassistant/package_constraints.txt b/homeassistant/package_constraints.txt
index 49d2f4f01cf..54df8ccf1ab 100644
--- a/homeassistant/package_constraints.txt
+++ b/homeassistant/package_constraints.txt
@@ -112,7 +112,8 @@ httpcore==1.0.5
 hyperframe>=5.2.0
 
 # Ensure we run compatible with musllinux build env
-numpy==1.26.4
+numpy==2.1.2
+pandas~=2.2.3
 
 # Constrain multidict to avoid typing issues
 # https://github.com/home-assistant/core/pull/67046
@@ -170,9 +171,6 @@ charset-normalizer==3.4.0
 # Roborock, NAM, Brother, and GIOS.
 dacite>=1.7.0
 
-# Musle wheels for pandas 2.2.0 cannot be build for any architecture.
-pandas==2.1.4
-
 # chacha20poly1305-reuseable==0.12.x is incompatible with cryptography==43.0.x
 chacha20poly1305-reuseable>=0.13.0
 
diff --git a/requirements_all.txt b/requirements_all.txt
index 8baf6ef1731..27b9c357b59 100644
--- a/requirements_all.txt
+++ b/requirements_all.txt
@@ -1491,7 +1491,7 @@ numato-gpio==0.13.0
 # homeassistant.components.stream
 # homeassistant.components.tensorflow
 # homeassistant.components.trend
-numpy==1.26.4
+numpy==2.1.2
 
 # homeassistant.components.nyt_games
 nyt_games==0.4.4
diff --git a/requirements_test_all.txt b/requirements_test_all.txt
index 0597a3174f7..3444b2b8558 100644
--- a/requirements_test_all.txt
+++ b/requirements_test_all.txt
@@ -1239,7 +1239,7 @@ numato-gpio==0.13.0
 # homeassistant.components.stream
 # homeassistant.components.tensorflow
 # homeassistant.components.trend
-numpy==1.26.4
+numpy==2.1.2
 
 # homeassistant.components.nyt_games
 nyt_games==0.4.4
diff --git a/script/gen_requirements_all.py b/script/gen_requirements_all.py
index 0f8354e1f60..352b209c5fc 100755
--- a/script/gen_requirements_all.py
+++ b/script/gen_requirements_all.py
@@ -127,7 +127,8 @@ httpcore==1.0.5
 hyperframe>=5.2.0
 
 # Ensure we run compatible with musllinux build env
-numpy==1.26.4
+numpy==2.1.2
+pandas~=2.2.3
 
 # Constrain multidict to avoid typing issues
 # https://github.com/home-assistant/core/pull/67046
@@ -185,9 +186,6 @@ charset-normalizer==3.4.0
 # Roborock, NAM, Brother, and GIOS.
 dacite>=1.7.0
 
-# Musle wheels for pandas 2.2.0 cannot be build for any architecture.
-pandas==2.1.4
-
 # chacha20poly1305-reuseable==0.12.x is incompatible with cryptography==43.0.x
 chacha20poly1305-reuseable>=0.13.0