diff --git a/homeassistant/components/dhcp/__init__.py b/homeassistant/components/dhcp/__init__.py
index 4310f8f2caf..dd247c4cab9 100644
--- a/homeassistant/components/dhcp/__init__.py
+++ b/homeassistant/components/dhcp/__init__.py
@@ -179,6 +179,7 @@ class WatcherBase:
             lowercase_hostname,
         )
 
+        matched_domains = set()
         for entry in self._integration_matchers:
             if MAC_ADDRESS in entry and not fnmatch.fnmatch(
                 uppercase_mac, entry[MAC_ADDRESS]
@@ -191,6 +192,11 @@ class WatcherBase:
                 continue
 
             _LOGGER.debug("Matched %s against %s", data, entry)
+            if entry["domain"] in matched_domains:
+                # Only match once per domain
+                continue
+
+            matched_domains.add(entry["domain"])
             discovery_flow.async_create_flow(
                 self.hass,
                 entry["domain"],
diff --git a/tests/components/dhcp/test_init.py b/tests/components/dhcp/test_init.py
index fb3387aeab6..0956230d787 100644
--- a/tests/components/dhcp/test_init.py
+++ b/tests/components/dhcp/test_init.py
@@ -255,6 +255,33 @@ async def test_dhcp_match_macaddress(hass):
     )
 
 
+async def test_dhcp_multiple_match_only_one_flow(hass):
+    """Test matching the domain multiple times only generates one flow."""
+    integration_matchers = [
+        {"domain": "mock-domain", "macaddress": "B8B7F1*"},
+        {"domain": "mock-domain", "hostname": "connect"},
+    ]
+
+    packet = Ether(RAW_DHCP_REQUEST)
+
+    async_handle_dhcp_packet = await _async_get_handle_dhcp_packet(
+        hass, integration_matchers
+    )
+    with patch.object(hass.config_entries.flow, "async_init") as mock_init:
+        await async_handle_dhcp_packet(packet)
+
+    assert len(mock_init.mock_calls) == 1
+    assert mock_init.mock_calls[0][1][0] == "mock-domain"
+    assert mock_init.mock_calls[0][2]["context"] == {
+        "source": config_entries.SOURCE_DHCP
+    }
+    assert mock_init.mock_calls[0][2]["data"] == dhcp.DhcpServiceInfo(
+        ip="192.168.210.56",
+        hostname="connect",
+        macaddress="b8b7f16db533",
+    )
+
+
 async def test_dhcp_match_macaddress_without_hostname(hass):
     """Test matching based on macaddress only."""
     integration_matchers = [{"domain": "mock-domain", "macaddress": "606BBD*"}]