diff --git a/.coveragerc b/.coveragerc
index 68679fe5519..38d2197701d 100644
--- a/.coveragerc
+++ b/.coveragerc
@@ -898,7 +898,6 @@ omit =
     homeassistant/components/pi4ioe5v9xxxx/binary_sensor.py
     homeassistant/components/pi4ioe5v9xxxx/switch.py
     homeassistant/components/picotts/tts.py
-    homeassistant/components/piglow/light.py
     homeassistant/components/pilight/*
     homeassistant/components/ping/__init__.py
     homeassistant/components/ping/const.py
diff --git a/homeassistant/components/piglow/__init__.py b/homeassistant/components/piglow/__init__.py
deleted file mode 100644
index e6d4bbd3ec2..00000000000
--- a/homeassistant/components/piglow/__init__.py
+++ /dev/null
@@ -1 +0,0 @@
-"""The piglow component."""
diff --git a/homeassistant/components/piglow/light.py b/homeassistant/components/piglow/light.py
deleted file mode 100644
index f66121ec413..00000000000
--- a/homeassistant/components/piglow/light.py
+++ /dev/null
@@ -1,129 +0,0 @@
-"""Support for Piglow LED's."""
-from __future__ import annotations
-
-import logging
-import subprocess
-
-import piglow
-import voluptuous as vol
-
-from homeassistant.components.light import (
-    ATTR_BRIGHTNESS,
-    ATTR_HS_COLOR,
-    PLATFORM_SCHEMA,
-    SUPPORT_BRIGHTNESS,
-    SUPPORT_COLOR,
-    LightEntity,
-)
-from homeassistant.const import CONF_NAME
-from homeassistant.core import HomeAssistant
-import homeassistant.helpers.config_validation as cv
-from homeassistant.helpers.entity_platform import AddEntitiesCallback
-from homeassistant.helpers.typing import ConfigType, DiscoveryInfoType
-import homeassistant.util.color as color_util
-
-_LOGGER = logging.getLogger(__name__)
-
-SUPPORT_PIGLOW = SUPPORT_BRIGHTNESS | SUPPORT_COLOR
-
-DEFAULT_NAME = "Piglow"
-
-PLATFORM_SCHEMA = PLATFORM_SCHEMA.extend(
-    {vol.Optional(CONF_NAME, default=DEFAULT_NAME): cv.string}
-)
-
-
-def setup_platform(
-    hass: HomeAssistant,
-    config: ConfigType,
-    add_entities: AddEntitiesCallback,
-    discovery_info: DiscoveryInfoType | None = None,
-) -> None:
-    """Set up the Piglow Light platform."""
-    _LOGGER.warning(
-        "The Piglow integration is deprecated and will be removed "
-        "in Home Assistant Core 2022.4; this integration is removed under "
-        "Architectural Decision Record 0019, more information can be found here: "
-        "https://github.com/home-assistant/architecture/blob/master/adr/0019-GPIO.md"
-    )
-
-    if subprocess.getoutput("i2cdetect  -q -y 1 | grep -o 54") != "54":
-        _LOGGER.error("A Piglow device was not found")
-        return
-
-    name = config.get(CONF_NAME)
-
-    add_entities([PiglowLight(name)])
-
-
-class PiglowLight(LightEntity):
-    """Representation of an Piglow Light."""
-
-    def __init__(self, name):
-        """Initialize an PiglowLight."""
-        self._name = name
-        self._is_on = False
-        self._brightness = 255
-        self._hs_color = [0, 0]
-
-    @property
-    def name(self):
-        """Return the display name of this light."""
-        return self._name
-
-    @property
-    def brightness(self):
-        """Return the brightness of the light."""
-        return self._brightness
-
-    @property
-    def hs_color(self):
-        """Read back the color of the light."""
-        return self._hs_color
-
-    @property
-    def supported_features(self):
-        """Flag supported features."""
-        return SUPPORT_PIGLOW
-
-    @property
-    def should_poll(self):
-        """Return if we should poll this device."""
-        return False
-
-    @property
-    def assumed_state(self) -> bool:
-        """Return True if unable to access real state of the entity."""
-        return True
-
-    @property
-    def is_on(self):
-        """Return true if light is on."""
-        return self._is_on
-
-    def turn_on(self, **kwargs):
-        """Instruct the light to turn on."""
-        piglow.clear()
-
-        if ATTR_BRIGHTNESS in kwargs:
-            self._brightness = kwargs[ATTR_BRIGHTNESS]
-
-        if ATTR_HS_COLOR in kwargs:
-            self._hs_color = kwargs[ATTR_HS_COLOR]
-
-        rgb = color_util.color_hsv_to_RGB(
-            self._hs_color[0], self._hs_color[1], self._brightness / 255 * 100
-        )
-        piglow.red(rgb[0])
-        piglow.green(rgb[1])
-        piglow.blue(rgb[2])
-        piglow.show()
-        self._is_on = True
-        self.schedule_update_ha_state()
-
-    def turn_off(self, **kwargs):
-        """Instruct the light to turn off."""
-        piglow.clear()
-        piglow.show()
-        self._is_on = False
-        self.schedule_update_ha_state()
diff --git a/homeassistant/components/piglow/manifest.json b/homeassistant/components/piglow/manifest.json
deleted file mode 100644
index f4b869aacf8..00000000000
--- a/homeassistant/components/piglow/manifest.json
+++ /dev/null
@@ -1,8 +0,0 @@
-{
-  "domain": "piglow",
-  "name": "Piglow",
-  "documentation": "https://www.home-assistant.io/integrations/piglow",
-  "requirements": ["piglow==1.2.4"],
-  "codeowners": [],
-  "iot_class": "local_polling"
-}
diff --git a/requirements_all.txt b/requirements_all.txt
index 866d4f8ce1e..a07faa1e3d6 100644
--- a/requirements_all.txt
+++ b/requirements_all.txt
@@ -1217,9 +1217,6 @@ pifacecommon==4.2.2
 # homeassistant.components.rpi_pfio
 pifacedigitalio==3.0.5
 
-# homeassistant.components.piglow
-piglow==1.2.4
-
 # homeassistant.components.pilight
 pilight==0.1.1