diff --git a/homeassistant/components/keenetic_ndms2/__init__.py b/homeassistant/components/keenetic_ndms2/__init__.py
index 787e6a5f5f1..473acac57cd 100644
--- a/homeassistant/components/keenetic_ndms2/__init__.py
+++ b/homeassistant/components/keenetic_ndms2/__init__.py
@@ -1,9 +1,14 @@
 """The keenetic_ndms2 component."""
+from __future__ import annotations
 
-from homeassistant.components import binary_sensor, device_tracker
+import logging
+
+from homeassistant.components.binary_sensor import DOMAIN as BINARY_SENSOR_DOMAIN
+from homeassistant.components.device_tracker import DOMAIN as DEVICE_TRACKER_DOMAIN
 from homeassistant.config_entries import ConfigEntry
 from homeassistant.const import CONF_HOST, CONF_SCAN_INTERVAL
 from homeassistant.core import HomeAssistant
+from homeassistant.helpers import device_registry, entity_registry
 
 from .const import (
     CONF_CONSIDER_HOME,
@@ -20,7 +25,8 @@ from .const import (
 )
 from .router import KeeneticRouter
 
-PLATFORMS = [device_tracker.DOMAIN, binary_sensor.DOMAIN]
+PLATFORMS = [BINARY_SENSOR_DOMAIN, DEVICE_TRACKER_DOMAIN]
+_LOGGER = logging.getLogger(__name__)
 
 
 async def async_setup_entry(hass: HomeAssistant, config_entry: ConfigEntry) -> bool:
@@ -57,6 +63,37 @@ async def async_unload_entry(hass: HomeAssistant, config_entry: ConfigEntry) ->
 
     hass.data[DOMAIN].pop(config_entry.entry_id)
 
+    new_tracked_interfaces: set[str] = set(config_entry.options[CONF_INTERFACES])
+
+    if router.tracked_interfaces - new_tracked_interfaces:
+        _LOGGER.debug(
+            "Cleaning device_tracker entities since some interfaces are now untracked:"
+        )
+        ent_reg = entity_registry.async_get(hass)
+        dev_reg = device_registry.async_get(hass)
+        # We keep devices currently connected to new_tracked_interfaces
+        keep_devices: set[str] = {
+            mac
+            for mac, device in router.last_devices.items()
+            if device.interface in new_tracked_interfaces
+        }
+        for entity_entry in list(ent_reg.entities.values()):
+            if (
+                entity_entry.config_entry_id == config_entry.entry_id
+                and entity_entry.domain == DEVICE_TRACKER_DOMAIN
+            ):
+                mac = entity_entry.unique_id.partition("_")[0]
+                if mac not in keep_devices:
+                    _LOGGER.debug("Removing entity %s", entity_entry.entity_id)
+
+                    ent_reg.async_remove(entity_entry.entity_id)
+                    dev_reg.async_update_device(
+                        entity_entry.device_id,
+                        remove_config_entry_id=config_entry.entry_id,
+                    )
+
+        _LOGGER.debug("Finished cleaning device_tracker entities")
+
     return unload_ok
 
 
diff --git a/homeassistant/components/keenetic_ndms2/router.py b/homeassistant/components/keenetic_ndms2/router.py
index 87841d8291c..d79f2591525 100644
--- a/homeassistant/components/keenetic_ndms2/router.py
+++ b/homeassistant/components/keenetic_ndms2/router.py
@@ -48,6 +48,7 @@ class KeeneticRouter:
         self._cancel_periodic_update: Callable | None = None
         self._available = False
         self._progress = None
+        self._tracked_interfaces = set(config_entry.options[CONF_INTERFACES])
 
     @property
     def client(self):
@@ -105,6 +106,11 @@ class KeeneticRouter:
         """Config entry option defining number of seconds from last seen to away."""
         return timedelta(seconds=self.config_entry.options[CONF_CONSIDER_HOME])
 
+    @property
+    def tracked_interfaces(self):
+        """Tracked interfaces."""
+        return self._tracked_interfaces
+
     @property
     def signal_update(self):
         """Event specific per router entry to signal updates."""
@@ -178,7 +184,7 @@ class KeeneticRouter:
             self._last_devices = {
                 dev.mac: dev
                 for dev in _response
-                if dev.interface in self.config_entry.options[CONF_INTERFACES]
+                if dev.interface in self._tracked_interfaces
             }
             _LOGGER.debug("Successfully fetched data from router: %s", str(_response))
             self._router_info = self._client.get_router_info()