diff --git a/homeassistant/package_constraints.txt b/homeassistant/package_constraints.txt
index 9b404e623e9..a09c00b7192 100644
--- a/homeassistant/package_constraints.txt
+++ b/homeassistant/package_constraints.txt
@@ -188,3 +188,6 @@ dacite>=1.7.0
 
 # Musle wheels for pandas 2.2.0 cannot be build for any architecture.
 pandas==2.1.4
+
+# chacha20poly1305-reuseable==0.12.0 is incompatible with cryptography==42.0.x
+chacha20poly1305-reuseable>=0.12.1
diff --git a/script/gen_requirements_all.py b/script/gen_requirements_all.py
index 64d897b7ee7..3e61a266ae1 100755
--- a/script/gen_requirements_all.py
+++ b/script/gen_requirements_all.py
@@ -181,6 +181,9 @@ dacite>=1.7.0
 
 # Musle wheels for pandas 2.2.0 cannot be build for any architecture.
 pandas==2.1.4
+
+# chacha20poly1305-reuseable==0.12.0 is incompatible with cryptography==42.0.x
+chacha20poly1305-reuseable>=0.12.1
 """
 
 GENERATED_MESSAGE = (