diff --git a/homeassistant/components/plugwise/config_flow.py b/homeassistant/components/plugwise/config_flow.py
index e69d92e3cd0..5b5c79ba2b8 100644
--- a/homeassistant/components/plugwise/config_flow.py
+++ b/homeassistant/components/plugwise/config_flow.py
@@ -3,7 +3,11 @@ from __future__ import annotations
 
 from typing import Any
 
-from plugwise.exceptions import InvalidAuthentication, PlugwiseException
+from plugwise.exceptions import (
+    InvalidAuthentication,
+    InvalidSetupError,
+    PlugwiseException,
+)
 from plugwise.smile import Smile
 import voluptuous as vol
 
@@ -124,6 +128,8 @@ class PlugwiseConfigFlow(ConfigFlow, domain=DOMAIN):
 
             try:
                 api = await validate_gw_input(self.hass, user_input)
+            except InvalidSetupError:
+                errors[CONF_BASE] = "invalid_setup"
             except InvalidAuthentication:
                 errors[CONF_BASE] = "invalid_auth"
             except PlugwiseException:
diff --git a/homeassistant/components/plugwise/strings.json b/homeassistant/components/plugwise/strings.json
index e5a7ab5a6a9..dfa0ac920c7 100644
--- a/homeassistant/components/plugwise/strings.json
+++ b/homeassistant/components/plugwise/strings.json
@@ -32,6 +32,7 @@
     "error": {
       "cannot_connect": "[%key:common::config_flow::error::cannot_connect%]",
       "invalid_auth": "[%key:common::config_flow::error::invalid_auth%]",
+      "invalid_setup": "Add your Adam instead of your Anna, see the Home Assistant Plugwise integration documentation for more information",
       "unknown": "[%key:common::config_flow::error::unknown%]"
     },
     "abort": {
diff --git a/tests/components/plugwise/test_config_flow.py b/tests/components/plugwise/test_config_flow.py
index 9fdd0323518..7668d492e75 100644
--- a/tests/components/plugwise/test_config_flow.py
+++ b/tests/components/plugwise/test_config_flow.py
@@ -4,6 +4,7 @@ from unittest.mock import AsyncMock, MagicMock, patch
 from plugwise.exceptions import (
     ConnectionFailedError,
     InvalidAuthentication,
+    InvalidSetupError,
     PlugwiseException,
 )
 import pytest
@@ -223,6 +224,7 @@ async def test_zercoconf_discovery_update_configuration(hass: HomeAssistant) ->
     "side_effect,reason",
     [
         (InvalidAuthentication, "invalid_auth"),
+        (InvalidSetupError, "invalid_setup"),
         (ConnectionFailedError, "cannot_connect"),
         (PlugwiseException, "cannot_connect"),
         (RuntimeError, "unknown"),