diff --git a/homeassistant/bootstrap.py b/homeassistant/bootstrap.py
index 9ac8b2ef6e6..8771fb41247 100644
--- a/homeassistant/bootstrap.py
+++ b/homeassistant/bootstrap.py
@@ -17,7 +17,7 @@ import voluptuous as vol
 import yarl
 
 from . import config as conf_util, config_entries, core, loader
-from .components import http, persistent_notification
+from .components import http
 from .const import (
     REQUIRED_NEXT_PYTHON_HA_RELEASE,
     REQUIRED_NEXT_PYTHON_VER,
@@ -268,16 +268,31 @@ async def async_from_config_dict(
         REQUIRED_NEXT_PYTHON_HA_RELEASE
         and sys.version_info[:3] < REQUIRED_NEXT_PYTHON_VER
     ):
-        msg = (
-            "Support for the running Python version "
-            f"{'.'.join(str(x) for x in sys.version_info[:3])} is deprecated and will "
-            f"be removed in Home Assistant {REQUIRED_NEXT_PYTHON_HA_RELEASE}. "
-            "Please upgrade Python to "
-            f"{'.'.join(str(x) for x in REQUIRED_NEXT_PYTHON_VER[:2])}."
+        current_python_version = ".".join(str(x) for x in sys.version_info[:3])
+        required_python_version = ".".join(str(x) for x in REQUIRED_NEXT_PYTHON_VER[:2])
+        _LOGGER.warning(
+            (
+                "Support for the running Python version %s is deprecated and "
+                "will be removed in Home Assistant %s; "
+                "Please upgrade Python to %s"
+            ),
+            current_python_version,
+            REQUIRED_NEXT_PYTHON_HA_RELEASE,
+            required_python_version,
         )
-        _LOGGER.warning(msg)
-        persistent_notification.async_create(
-            hass, msg, "Python version", "python_version"
+        issue_registry.async_create_issue(
+            hass,
+            core.DOMAIN,
+            "python_version",
+            is_fixable=False,
+            severity=issue_registry.IssueSeverity.WARNING,
+            breaks_in_ha_version=REQUIRED_NEXT_PYTHON_HA_RELEASE,
+            translation_key="python_version",
+            translation_placeholders={
+                "current_python_version": current_python_version,
+                "required_python_version": required_python_version,
+                "breaks_in_ha_version": REQUIRED_NEXT_PYTHON_HA_RELEASE,
+            },
         )
 
     return hass
diff --git a/homeassistant/components/homeassistant/strings.json b/homeassistant/components/homeassistant/strings.json
index 2db00081eaa..d7c5216111c 100644
--- a/homeassistant/components/homeassistant/strings.json
+++ b/homeassistant/components/homeassistant/strings.json
@@ -3,6 +3,10 @@
     "historic_currency": {
       "title": "The configured currency is no longer in use",
       "description": "The currency {currency} is no longer in use, please reconfigure the currency configuration."
+    },
+    "python_version": {
+      "title": "Support for Python {current_python_version} is being removed",
+      "description": "Support for running Home Assistant in the current used Python version {current_python_version} is deprecated and will be removed in Home Assistant {breaks_in_ha_version}. Please upgrade Python to {required_python_version} to prevent your Home Assistant instance from breaking."
     }
   },
   "system_health": {
diff --git a/homeassistant/components/homeassistant/translations/en.json b/homeassistant/components/homeassistant/translations/en.json
index 8008aa813aa..b41e5753995 100644
--- a/homeassistant/components/homeassistant/translations/en.json
+++ b/homeassistant/components/homeassistant/translations/en.json
@@ -3,6 +3,10 @@
         "historic_currency": {
             "description": "The currency {currency} is no longer in use, please reconfigure the currency configuration.",
             "title": "The configured currency is no longer in use"
+        },
+        "python_version": {
+            "description": "Support for running Home Assistant in the current used Python version {current_python_version} is deprecated and will be removed in Home Assistant {breaks_in_ha_version}. Please upgrade Python to {required_python_version} to prevent your Home Assistant instance from breaking.",
+            "title": "Support for Python {current_python_version} is being removed"
         }
     },
     "system_health": {
diff --git a/homeassistant/const.py b/homeassistant/const.py
index 6fe8f3730ff..4201c7f2de4 100644
--- a/homeassistant/const.py
+++ b/homeassistant/const.py
@@ -12,9 +12,9 @@ PATCH_VERSION: Final = "0.dev0"
 __short_version__: Final = f"{MAJOR_VERSION}.{MINOR_VERSION}"
 __version__: Final = f"{__short_version__}.{PATCH_VERSION}"
 REQUIRED_PYTHON_VER: Final[tuple[int, int, int]] = (3, 9, 0)
-REQUIRED_NEXT_PYTHON_VER: Final[tuple[int, int, int]] = (3, 9, 0)
+REQUIRED_NEXT_PYTHON_VER: Final[tuple[int, int, int]] = (3, 10, 0)
 # Truthy date string triggers showing related deprecation warning messages.
-REQUIRED_NEXT_PYTHON_HA_RELEASE: Final = ""
+REQUIRED_NEXT_PYTHON_HA_RELEASE: Final = "2023.2"
 
 # Format for platform files
 PLATFORM_FORMAT: Final = "{platform}.{domain}"
diff --git a/script/hassfest/requirements.py b/script/hassfest/requirements.py
index b8fb22fb786..0e72e2eabd6 100644
--- a/script/hassfest/requirements.py
+++ b/script/hassfest/requirements.py
@@ -32,7 +32,8 @@ SUPPORTED_PYTHON_TUPLES = [
 ]
 if REQUIRED_PYTHON_VER[0] == REQUIRED_NEXT_PYTHON_VER[0]:
     for minor in range(REQUIRED_PYTHON_VER[1] + 1, REQUIRED_NEXT_PYTHON_VER[1] + 1):
-        SUPPORTED_PYTHON_TUPLES.append((REQUIRED_PYTHON_VER[0], minor))
+        if minor < 10:  # stdlib list does not support 3.10+
+            SUPPORTED_PYTHON_TUPLES.append((REQUIRED_PYTHON_VER[0], minor))
 SUPPORTED_PYTHON_VERSIONS = [
     ".".join(map(str, version_tuple)) for version_tuple in SUPPORTED_PYTHON_TUPLES
 ]