diff --git a/homeassistant/components/telegram_bot/bot.py b/homeassistant/components/telegram_bot/bot.py
index 534923b3568..f313972635f 100644
--- a/homeassistant/components/telegram_bot/bot.py
+++ b/homeassistant/components/telegram_bot/bot.py
@@ -321,8 +321,8 @@ class TelegramNotificationService:
                 for key in row_keyboard.split(","):
                     if ":/" in key:
                         # check if command or URL
-                        if key.startswith("https://"):
-                            label = key.split(",")[0]
+                        if "https://" in key:
+                            label = key.split(":")[0]
                             url = key[len(label) + 1 :]
                             buttons.append(InlineKeyboardButton(label, url=url))
                         else:
diff --git a/tests/components/telegram_bot/test_telegram_bot.py b/tests/components/telegram_bot/test_telegram_bot.py
index 24b6deb27b5..fd313867561 100644
--- a/tests/components/telegram_bot/test_telegram_bot.py
+++ b/tests/components/telegram_bot/test_telegram_bot.py
@@ -1,12 +1,14 @@
 """Tests for the telegram_bot component."""
 
 import base64
+from datetime import datetime
 import io
 from typing import Any
 from unittest.mock import AsyncMock, MagicMock, mock_open, patch
 
 import pytest
-from telegram import Update
+from telegram import Chat, InlineKeyboardButton, InlineKeyboardMarkup, Message, Update
+from telegram.constants import ChatType, ParseMode
 from telegram.error import (
     InvalidToken,
     NetworkError,
@@ -16,28 +18,37 @@ from telegram.error import (
 )
 
 from homeassistant.components.telegram_bot import (
+    ATTR_LATITUDE,
+    ATTR_LONGITUDE,
+    async_setup_entry,
+)
+from homeassistant.components.telegram_bot.const import (
     ATTR_AUTHENTICATION,
     ATTR_CALLBACK_QUERY_ID,
     ATTR_CAPTION,
     ATTR_CHAT_ID,
+    ATTR_DISABLE_NOTIF,
+    ATTR_DISABLE_WEB_PREV,
     ATTR_FILE,
+    ATTR_KEYBOARD,
     ATTR_KEYBOARD_INLINE,
-    ATTR_LATITUDE,
-    ATTR_LONGITUDE,
     ATTR_MESSAGE,
+    ATTR_MESSAGE_TAG,
     ATTR_MESSAGE_THREAD_ID,
     ATTR_MESSAGEID,
     ATTR_OPTIONS,
+    ATTR_PARSER,
     ATTR_PASSWORD,
     ATTR_QUESTION,
+    ATTR_REPLY_TO_MSGID,
     ATTR_SHOW_ALERT,
     ATTR_STICKER_ID,
     ATTR_TARGET,
+    ATTR_TIMEOUT,
     ATTR_URL,
     ATTR_USERNAME,
     ATTR_VERIFY_SSL,
     CONF_CONFIG_ENTRY_ID,
-    CONF_PLATFORM,
     DOMAIN,
     PLATFORM_BROADCAST,
     SERVICE_ANSWER_CALLBACK_QUERY,
@@ -55,12 +66,12 @@ from homeassistant.components.telegram_bot import (
     SERVICE_SEND_STICKER,
     SERVICE_SEND_VIDEO,
     SERVICE_SEND_VOICE,
-    async_setup_entry,
 )
 from homeassistant.components.telegram_bot.webhooks import TELEGRAM_WEBHOOK_URL
 from homeassistant.config_entries import SOURCE_USER
 from homeassistant.const import (
     CONF_API_KEY,
+    CONF_PLATFORM,
     HTTP_BASIC_AUTHENTICATION,
     HTTP_BEARER_AUTHENTICATION,
     HTTP_DIGEST_AUTHENTICATION,
@@ -96,6 +107,26 @@ async def test_polling_platform_init(hass: HomeAssistant, polling_platform) -> N
             SERVICE_SEND_MESSAGE,
             {ATTR_MESSAGE: "test_message", ATTR_MESSAGE_THREAD_ID: "123"},
         ),
+        (
+            SERVICE_SEND_MESSAGE,
+            {
+                ATTR_KEYBOARD: ["/command1, /command2", "/command3"],
+                ATTR_MESSAGE: "test_message",
+                ATTR_PARSER: ParseMode.HTML,
+                ATTR_TIMEOUT: 15,
+                ATTR_DISABLE_NOTIF: True,
+                ATTR_DISABLE_WEB_PREV: True,
+                ATTR_MESSAGE_TAG: "mock_tag",
+                ATTR_REPLY_TO_MSGID: 12345,
+            },
+        ),
+        (
+            SERVICE_SEND_MESSAGE,
+            {
+                ATTR_KEYBOARD: [],
+                ATTR_MESSAGE: "test_message",
+            },
+        ),
         (
             SERVICE_SEND_STICKER,
             {
@@ -145,6 +176,95 @@ async def test_send_message(
     assert (response["chats"][0]["message_id"]) == 12345
 
 
+@pytest.mark.parametrize(
+    ("input", "expected"),
+    [
+        (
+            {
+                ATTR_MESSAGE: "test_message",
+                ATTR_KEYBOARD_INLINE: "command1:/cmd1,/cmd2,mock_link:https://mock_link",
+            },
+            InlineKeyboardMarkup(
+                # 1 row with 3 buttons
+                [
+                    [
+                        InlineKeyboardButton(callback_data="/cmd1", text="command1"),
+                        InlineKeyboardButton(callback_data="/cmd2", text="CMD2"),
+                        InlineKeyboardButton(url="https://mock_link", text="mock_link"),
+                    ]
+                ]
+            ),
+        ),
+        (
+            {
+                ATTR_MESSAGE: "test_message",
+                ATTR_KEYBOARD_INLINE: [
+                    [["command1", "/cmd1"]],
+                    [["mock_link", "https://mock_link"]],
+                ],
+            },
+            InlineKeyboardMarkup(
+                # 2 rows each with 1 button
+                [
+                    [InlineKeyboardButton(callback_data="/cmd1", text="command1")],
+                    [InlineKeyboardButton(url="https://mock_link", text="mock_link")],
+                ]
+            ),
+        ),
+    ],
+)
+async def test_send_message_with_inline_keyboard(
+    hass: HomeAssistant,
+    webhook_platform,
+    input: dict[str, Any],
+    expected: InlineKeyboardMarkup,
+) -> None:
+    """Test the send_message service.
+
+    Tests any service that does not require files to be sent.
+    """
+    context = Context()
+    events = async_capture_events(hass, "telegram_sent")
+
+    with patch(
+        "homeassistant.components.telegram_bot.bot.Bot.send_message",
+        AsyncMock(
+            return_value=Message(
+                message_id=12345,
+                date=datetime.now(),
+                chat=Chat(id=123456, type=ChatType.PRIVATE),
+            )
+        ),
+    ) as mock_send_message:
+        response = await hass.services.async_call(
+            DOMAIN,
+            SERVICE_SEND_MESSAGE,
+            input,
+            blocking=True,
+            context=context,
+            return_response=True,
+        )
+        await hass.async_block_till_done()
+
+        mock_send_message.assert_called_once_with(
+            12345678,
+            "test_message",
+            parse_mode=ParseMode.MARKDOWN,
+            disable_web_page_preview=None,
+            disable_notification=False,
+            reply_to_message_id=None,
+            reply_markup=expected,
+            read_timeout=None,
+            message_thread_id=None,
+        )
+
+    assert len(events) == 1
+    assert events[0].context == context
+
+    assert len(response["chats"]) == 1
+    assert (response["chats"][0]["message_id"]) == 12345
+
+
 @patch(
     "builtins.open",
     mock_open(