diff --git a/.github/workflows/wheels.yml b/.github/workflows/wheels.yml
index 583a2ea4211..0497ac32e86 100644
--- a/.github/workflows/wheels.yml
+++ b/.github/workflows/wheels.yml
@@ -41,6 +41,7 @@ jobs:
             echo "GRPC_BUILD_WITH_BORING_SSL_ASM=false"
             echo "GRPC_PYTHON_BUILD_SYSTEM_OPENSSL=true"
             echo "GRPC_PYTHON_BUILD_WITH_CYTHON=true"
+            echo "GRPC_PYTHON_DISABLE_LIBC_COMPATIBILITY=true"
           ) > .env_file
 
       - name: Upload env_file