diff --git a/.strict-typing b/.strict-typing
index a206f562c17..364a3d0db6a 100644
--- a/.strict-typing
+++ b/.strict-typing
@@ -20,6 +20,7 @@ homeassistant.helpers.entity_values
 homeassistant.helpers.reload
 homeassistant.helpers.script_variables
 homeassistant.helpers.translation
+homeassistant.util.async_
 homeassistant.util.color
 homeassistant.util.process
 homeassistant.util.unit_system
diff --git a/homeassistant/util/async_.py b/homeassistant/util/async_.py
index b898efe49fe..b27ddbda382 100644
--- a/homeassistant/util/async_.py
+++ b/homeassistant/util/async_.py
@@ -11,14 +11,20 @@ import threading
 from traceback import extract_stack
 from typing import Any, TypeVar
 
+from typing_extensions import ParamSpec
+
 _LOGGER = logging.getLogger(__name__)
 
 _SHUTDOWN_RUN_CALLBACK_THREADSAFE = "_shutdown_run_callback_threadsafe"
 
-T = TypeVar("T")
+_T = TypeVar("_T")
+_R = TypeVar("_R")
+_P = ParamSpec("_P")
 
 
-def fire_coroutine_threadsafe(coro: Coroutine, loop: AbstractEventLoop) -> None:
+def fire_coroutine_threadsafe(
+    coro: Coroutine[Any, Any, Any], loop: AbstractEventLoop
+) -> None:
     """Submit a coroutine object to a given event loop.
 
     This method does not provide a way to retrieve the result and
@@ -40,8 +46,8 @@ def fire_coroutine_threadsafe(coro: Coroutine, loop: AbstractEventLoop) -> None:
 
 
 def run_callback_threadsafe(
-    loop: AbstractEventLoop, callback: Callable[..., T], *args: Any
-) -> concurrent.futures.Future[T]:
+    loop: AbstractEventLoop, callback: Callable[..., _T], *args: Any
+) -> concurrent.futures.Future[_T]:
     """Submit a callback object to a given event loop.
 
     Return a concurrent.futures.Future to access the result.
@@ -50,7 +56,7 @@ def run_callback_threadsafe(
     if ident is not None and ident == threading.get_ident():
         raise RuntimeError("Cannot be called from within the event loop")
 
-    future: concurrent.futures.Future = concurrent.futures.Future()
+    future: concurrent.futures.Future[_T] = concurrent.futures.Future()
 
     def run_callback() -> None:
         """Run callback and store result."""
@@ -88,7 +94,7 @@ def run_callback_threadsafe(
     return future
 
 
-def check_loop(func: Callable, strict: bool = True) -> None:
+def check_loop(func: Callable[..., Any], strict: bool = True) -> None:
     """Warn if called inside the event loop. Raise if `strict` is True."""
     try:
         get_running_loop()
@@ -159,11 +165,11 @@ def check_loop(func: Callable, strict: bool = True) -> None:
         )
 
 
-def protect_loop(func: Callable, strict: bool = True) -> Callable:
+def protect_loop(func: Callable[_P, _R], strict: bool = True) -> Callable[_P, _R]:
     """Protect function from running in event loop."""
 
     @functools.wraps(func)
-    def protected_loop_func(*args, **kwargs):  # type: ignore
+    def protected_loop_func(*args: _P.args, **kwargs: _P.kwargs) -> _R:
         check_loop(func, strict=strict)
         return func(*args, **kwargs)
 
diff --git a/mypy.ini b/mypy.ini
index bbab7d20f80..8372a98d332 100644
--- a/mypy.ini
+++ b/mypy.ini
@@ -70,6 +70,9 @@ disallow_any_generics = true
 [mypy-homeassistant.helpers.translation]
 disallow_any_generics = true
 
+[mypy-homeassistant.util.async_]
+disallow_any_generics = true
+
 [mypy-homeassistant.util.color]
 disallow_any_generics = true