diff --git a/homeassistant/components/bluetooth/__init__.py b/homeassistant/components/bluetooth/__init__.py
index b6058767669..ea058a72759 100644
--- a/homeassistant/components/bluetooth/__init__.py
+++ b/homeassistant/components/bluetooth/__init__.py
@@ -71,7 +71,7 @@ ADDRESS: Final = "address"
 LOCAL_NAME: Final = "local_name"
 SERVICE_UUID: Final = "service_uuid"
 MANUFACTURER_ID: Final = "manufacturer_id"
-MANUFACTURER_DATA_FIRST_BYTE: Final = "manufacturer_data_first_byte"
+MANUFACTURER_DATA_START: Final = "manufacturer_data_start"
 
 
 BluetoothChange = Enum("BluetoothChange", "ADVERTISEMENT")
@@ -157,14 +157,16 @@ def _ble_device_matches(
         return False
 
     if (
-        matcher_manufacturer_data_first_byte := matcher.get(
-            MANUFACTURER_DATA_FIRST_BYTE
+        matcher_manufacturer_data_start := matcher.get(MANUFACTURER_DATA_START)
+    ) is not None:
+        matcher_manufacturer_data_start_bytes = bytearray(
+            matcher_manufacturer_data_start
         )
-    ) is not None and not any(
-        matcher_manufacturer_data_first_byte == manufacturer_data[0]
-        for manufacturer_data in advertisement_data.manufacturer_data.values()
-    ):
-        return False
+        if not any(
+            manufacturer_data.startswith(matcher_manufacturer_data_start_bytes)
+            for manufacturer_data in advertisement_data.manufacturer_data.values()
+        ):
+            return False
 
     return True
 
diff --git a/homeassistant/components/homekit_controller/manifest.json b/homeassistant/components/homekit_controller/manifest.json
index a4f5350a167..17692476834 100644
--- a/homeassistant/components/homekit_controller/manifest.json
+++ b/homeassistant/components/homekit_controller/manifest.json
@@ -5,7 +5,7 @@
   "documentation": "https://www.home-assistant.io/integrations/homekit_controller",
   "requirements": ["aiohomekit==1.1.4"],
   "zeroconf": ["_hap._tcp.local.", "_hap._udp.local."],
-  "bluetooth": [{ "manufacturer_id": 76, "manufacturer_data_first_byte": 6 }],
+  "bluetooth": [{ "manufacturer_id": 76, "manufacturer_data_start": [6] }],
   "after_dependencies": ["zeroconf"],
   "codeowners": ["@Jc2k", "@bdraco"],
   "iot_class": "local_push",
diff --git a/homeassistant/generated/bluetooth.py b/homeassistant/generated/bluetooth.py
index feac27af1f1..03486b6043c 100644
--- a/homeassistant/generated/bluetooth.py
+++ b/homeassistant/generated/bluetooth.py
@@ -6,11 +6,13 @@ from __future__ import annotations
 
 # fmt: off
 
-BLUETOOTH: list[dict[str, str | int]] = [
+BLUETOOTH: list[dict[str, str | int | list[int]]] = [
     {
         "domain": "homekit_controller",
         "manufacturer_id": 76,
-        "manufacturer_data_first_byte": 6
+        "manufacturer_data_start": [
+            6
+        ]
     },
     {
         "domain": "switchbot",
diff --git a/homeassistant/loader.py b/homeassistant/loader.py
index d0e6189ef96..9de06c48786 100644
--- a/homeassistant/loader.py
+++ b/homeassistant/loader.py
@@ -89,7 +89,7 @@ class BluetoothMatcherOptional(TypedDict, total=False):
     local_name: str
     service_uuid: str
     manufacturer_id: int
-    manufacturer_data_first_byte: int
+    manufacturer_data_start: list[int]
 
 
 class BluetoothMatcher(BluetoothMatcherRequired, BluetoothMatcherOptional):
diff --git a/script/hassfest/bluetooth.py b/script/hassfest/bluetooth.py
index 77a8779efbd..d8277213f27 100644
--- a/script/hassfest/bluetooth.py
+++ b/script/hassfest/bluetooth.py
@@ -14,7 +14,7 @@ from __future__ import annotations
 
 # fmt: off
 
-BLUETOOTH: list[dict[str, str | int]] = {}
+BLUETOOTH: list[dict[str, str | int | list[int]]] = {}
 """.strip()
 
 
diff --git a/script/hassfest/manifest.py b/script/hassfest/manifest.py
index 4f76fb9ed1e..9c1bd0a63f3 100644
--- a/script/hassfest/manifest.py
+++ b/script/hassfest/manifest.py
@@ -196,7 +196,7 @@ MANIFEST_SCHEMA = vol.Schema(
                     vol.Optional("service_uuid"): vol.All(str, verify_lowercase),
                     vol.Optional("local_name"): vol.All(str),
                     vol.Optional("manufacturer_id"): int,
-                    vol.Optional("manufacturer_data_first_byte"): int,
+                    vol.Optional("manufacturer_data_start"): [int],
                 }
             )
         ],
diff --git a/tests/components/bluetooth/test_init.py b/tests/components/bluetooth/test_init.py
index ec737cef593..a31f911f6a7 100644
--- a/tests/components/bluetooth/test_init.py
+++ b/tests/components/bluetooth/test_init.py
@@ -153,12 +153,12 @@ async def test_discovery_match_by_local_name(hass, mock_bleak_scanner_start):
 async def test_discovery_match_by_manufacturer_id_and_first_byte(
     hass, mock_bleak_scanner_start
 ):
-    """Test bluetooth discovery match by manufacturer_id and manufacturer_data_first_byte."""
+    """Test bluetooth discovery match by manufacturer_id and manufacturer_data_start."""
     mock_bt = [
         {
             "domain": "homekit_controller",
             "manufacturer_id": 76,
-            "manufacturer_data_first_byte": 0x06,
+            "manufacturer_data_start": [0x06, 0x02, 0x03],
         }
     ]
     with patch(
@@ -174,7 +174,9 @@ async def test_discovery_match_by_manufacturer_id_and_first_byte(
 
         hkc_device = BLEDevice("44:44:33:11:23:45", "lock")
         hkc_adv = AdvertisementData(
-            local_name="lock", service_uuids=[], manufacturer_data={76: b"\x06"}
+            local_name="lock",
+            service_uuids=[],
+            manufacturer_data={76: b"\x06\x02\x03\x99"},
         )
 
         models.HA_BLEAK_SCANNER._callback(hkc_device, hkc_adv)
diff --git a/tests/test_loader.py b/tests/test_loader.py
index b8a469f80aa..da788e0db75 100644
--- a/tests/test_loader.py
+++ b/tests/test_loader.py
@@ -205,7 +205,7 @@ def test_integration_properties(hass):
                 {"hostname": "tesla_*", "macaddress": "98ED5C*"},
                 {"registered_devices": True},
             ],
-            "bluetooth": [{"manufacturer_id": 76, "manufacturer_data_first_byte": 6}],
+            "bluetooth": [{"manufacturer_id": 76, "manufacturer_data_start": [0x06]}],
             "usb": [
                 {"vid": "10C4", "pid": "EA60"},
                 {"vid": "1CF1", "pid": "0030"},
@@ -244,7 +244,7 @@ def test_integration_properties(hass):
         {"vid": "10C4", "pid": "8A2A"},
     ]
     assert integration.bluetooth == [
-        {"manufacturer_id": 76, "manufacturer_data_first_byte": 6}
+        {"manufacturer_id": 76, "manufacturer_data_start": [0x06]}
     ]
     assert integration.ssdp == [
         {