diff --git a/homeassistant/components/reolink/__init__.py b/homeassistant/components/reolink/__init__.py
index 46761beae00..eca5a5aa853 100644
--- a/homeassistant/components/reolink/__init__.py
+++ b/homeassistant/components/reolink/__init__.py
@@ -16,6 +16,7 @@ from homeassistant.config_entries import ConfigEntry
 from homeassistant.const import EVENT_HOMEASSISTANT_STOP, Platform
 from homeassistant.core import HomeAssistant
 from homeassistant.exceptions import ConfigEntryAuthFailed, ConfigEntryNotReady
+from homeassistant.helpers import device_registry as dr, entity_registry as er
 from homeassistant.helpers.update_coordinator import DataUpdateCoordinator, UpdateFailed
 
 from .const import DOMAIN
@@ -148,6 +149,8 @@ async def async_setup_entry(hass: HomeAssistant, config_entry: ConfigEntry) -> b
         firmware_coordinator=firmware_coordinator,
     )
 
+    cleanup_disconnected_cams(hass, config_entry.entry_id, host)
+
     await hass.config_entries.async_forward_entry_setups(config_entry, PLATFORMS)
 
     config_entry.async_on_unload(
@@ -175,3 +178,56 @@ async def async_unload_entry(hass: HomeAssistant, config_entry: ConfigEntry) ->
         hass.data[DOMAIN].pop(config_entry.entry_id)
 
     return unload_ok
+
+
+def cleanup_disconnected_cams(
+    hass: HomeAssistant, config_entry_id: str, host: ReolinkHost
+) -> None:
+    """Clean-up disconnected camera channels or channels where a different model camera is connected."""
+    if not host.api.is_nvr:
+        return
+
+    device_reg = dr.async_get(hass)
+    devices = dr.async_entries_for_config_entry(device_reg, config_entry_id)
+    for device in devices:
+        device_id = [
+            dev_id[1].split("_ch")
+            for dev_id in device.identifiers
+            if dev_id[0] == DOMAIN
+        ][0]
+
+        if len(device_id) < 2:
+            # Do not consider the NVR itself
+            continue
+
+        ch = int(device_id[1])
+        ch_model = host.api.camera_model(ch)
+        remove = False
+        if ch not in host.api.channels:
+            remove = True
+            _LOGGER.debug(
+                "Removing Reolink device %s, since no camera is connected to NVR channel %s anymore",
+                device.name,
+                ch,
+            )
+        if ch_model not in [device.model, "Unknown"]:
+            remove = True
+            _LOGGER.debug(
+                "Removing Reolink device %s, since the camera model connected to channel %s changed from %s to %s",
+                device.name,
+                ch,
+                device.model,
+                ch_model,
+            )
+        if not remove:
+            continue
+
+        # clean entity and device registry
+        entity_reg = er.async_get(hass)
+        entities = er.async_entries_for_device(
+            entity_reg, device.id, include_disabled_entities=True
+        )
+        for entity in entities:
+            entity_reg.async_remove(entity.entity_id)
+
+        device_reg.async_remove_device(device.id)
diff --git a/tests/components/reolink/conftest.py b/tests/components/reolink/conftest.py
index 75d2dc0c661..464d4120c65 100644
--- a/tests/components/reolink/conftest.py
+++ b/tests/components/reolink/conftest.py
@@ -25,6 +25,8 @@ TEST_PORT = 1234
 TEST_NVR_NAME = "test_reolink_name"
 TEST_NVR_NAME2 = "test2_reolink_name"
 TEST_USE_HTTPS = True
+TEST_HOST_MODEL = "RLN8-410"
+TEST_CAM_MODEL = "RLC-123"
 
 
 @pytest.fixture
@@ -70,8 +72,8 @@ def reolink_connect_class(
         host_mock.hardware_version = "IPC_00000"
         host_mock.sw_version = "v1.0.0.0.0.0000"
         host_mock.manufacturer = "Reolink"
-        host_mock.model = "RLC-123"
-        host_mock.camera_model.return_value = "RLC-123"
+        host_mock.model = TEST_HOST_MODEL
+        host_mock.camera_model.return_value = TEST_CAM_MODEL
         host_mock.camera_name.return_value = TEST_NVR_NAME
         host_mock.camera_sw_version.return_value = "v1.1.0.0.0.0000"
         host_mock.session_active = True
diff --git a/tests/components/reolink/snapshots/test_diagnostics.ambr b/tests/components/reolink/snapshots/test_diagnostics.ambr
index 604a9364320..9f70673695c 100644
--- a/tests/components/reolink/snapshots/test_diagnostics.ambr
+++ b/tests/components/reolink/snapshots/test_diagnostics.ambr
@@ -41,7 +41,7 @@
     'event connection': 'Fast polling',
     'firmware version': 'v1.0.0.0.0.0000',
     'hardware version': 'IPC_00000',
-    'model': 'RLC-123',
+    'model': 'RLN8-410',
     'stream channels': list([
       0,
     ]),
diff --git a/tests/components/reolink/test_init.py b/tests/components/reolink/test_init.py
index e2bd622bb43..6a9a8b957db 100644
--- a/tests/components/reolink/test_init.py
+++ b/tests/components/reolink/test_init.py
@@ -11,11 +11,15 @@ from homeassistant.config import async_process_ha_core_config
 from homeassistant.config_entries import ConfigEntryState
 from homeassistant.const import STATE_OFF, STATE_UNAVAILABLE, Platform
 from homeassistant.core import HomeAssistant
-from homeassistant.helpers import issue_registry as ir
+from homeassistant.helpers import (
+    device_registry as dr,
+    entity_registry as er,
+    issue_registry as ir,
+)
 from homeassistant.setup import async_setup_component
 from homeassistant.util.dt import utcnow
 
-from .conftest import TEST_NVR_NAME
+from .conftest import TEST_CAM_MODEL, TEST_HOST_MODEL, TEST_NVR_NAME
 
 from tests.common import MockConfigEntry, async_fire_time_changed
 
@@ -102,6 +106,7 @@ async def test_entry_reloading(
     reolink_connect: MagicMock,
 ) -> None:
     """Test the entry is reloaded correctly when settings change."""
+    reolink_connect.is_nvr = False
     assert await hass.config_entries.async_setup(config_entry.entry_id)
     await hass.async_block_till_done()
 
@@ -115,6 +120,58 @@ async def test_entry_reloading(
     assert config_entry.title == "New Name"
 
 
+@pytest.mark.parametrize(
+    ("attr", "value", "expected_models"),
+    [
+        (
+            None,
+            None,
+            [TEST_HOST_MODEL, TEST_CAM_MODEL],
+        ),
+        ("channels", [], [TEST_HOST_MODEL]),
+        (
+            "camera_model",
+            Mock(return_value="RLC-567"),
+            [TEST_HOST_MODEL, "RLC-567"],
+        ),
+    ],
+)
+async def test_cleanup_disconnected_cams(
+    hass: HomeAssistant,
+    config_entry: MockConfigEntry,
+    reolink_connect: MagicMock,
+    device_registry: dr.DeviceRegistry,
+    entity_registry: er.EntityRegistry,
+    attr: str | None,
+    value: Any,
+    expected_models: list[str],
+) -> None:
+    """Test device and entity registry are cleaned up when camera is disconnected from NVR."""
+    reolink_connect.channels = [0]
+    # setup CH 0 and NVR switch entities/device
+    with patch("homeassistant.components.reolink.PLATFORMS", [Platform.SWITCH]):
+        assert await hass.config_entries.async_setup(config_entry.entry_id)
+    await hass.async_block_till_done()
+
+    device_entries = dr.async_entries_for_config_entry(
+        device_registry, config_entry.entry_id
+    )
+    device_models = [device.model for device in device_entries]
+    assert sorted(device_models) == sorted([TEST_HOST_MODEL, TEST_CAM_MODEL])
+
+    # reload integration after 'disconnecting' a camera.
+    if attr is not None:
+        setattr(reolink_connect, attr, value)
+    with patch("homeassistant.components.reolink.PLATFORMS", [Platform.SWITCH]):
+        assert await hass.config_entries.async_reload(config_entry.entry_id)
+
+    device_entries = dr.async_entries_for_config_entry(
+        device_registry, config_entry.entry_id
+    )
+    device_models = [device.model for device in device_entries]
+    assert sorted(device_models) == sorted(expected_models)
+
+
 async def test_no_repair_issue(
     hass: HomeAssistant, config_entry: MockConfigEntry
 ) -> None: