diff --git a/homeassistant/components/youtube/config_flow.py b/homeassistant/components/youtube/config_flow.py
index a2adebc84af..92695f80a2e 100644
--- a/homeassistant/components/youtube/config_flow.py
+++ b/homeassistant/components/youtube/config_flow.py
@@ -22,7 +22,13 @@ from homeassistant.helpers.selector import (
     SelectSelectorConfig,
 )
 
-from .const import CONF_CHANNELS, DEFAULT_ACCESS, DOMAIN, LOGGER
+from .const import (
+    CHANNEL_CREATION_HELP_URL,
+    CONF_CHANNELS,
+    DEFAULT_ACCESS,
+    DOMAIN,
+    LOGGER,
+)
 
 
 async def get_resource(hass: HomeAssistant, token: str) -> Resource:
@@ -99,6 +105,11 @@ class OAuth2FlowHandler(
             response = await self.hass.async_add_executor_job(
                 own_channel_request.execute
             )
+            if not response["items"]:
+                return self.async_abort(
+                    reason="no_channel",
+                    description_placeholders={"support_url": CHANNEL_CREATION_HELP_URL},
+                )
             own_channel = response["items"][0]
         except HttpError as ex:
             error = ex.reason
diff --git a/homeassistant/components/youtube/const.py b/homeassistant/components/youtube/const.py
index e2757e3856d..7404cd04665 100644
--- a/homeassistant/components/youtube/const.py
+++ b/homeassistant/components/youtube/const.py
@@ -4,6 +4,7 @@ import logging
 DEFAULT_ACCESS = ["https://www.googleapis.com/auth/youtube.readonly"]
 DOMAIN = "youtube"
 MANUFACTURER = "Google, Inc."
+CHANNEL_CREATION_HELP_URL = "https://support.google.com/youtube/answer/1646861"
 
 CONF_CHANNELS = "channels"
 CONF_ID = "id"
diff --git a/homeassistant/components/youtube/strings.json b/homeassistant/components/youtube/strings.json
index 24369ab26f9..eb89738708e 100644
--- a/homeassistant/components/youtube/strings.json
+++ b/homeassistant/components/youtube/strings.json
@@ -2,6 +2,7 @@
   "config": {
     "abort": {
       "access_not_configured": "Please read the below message we got from Google:\n\n{message}",
+      "no_channel": "Please create a YouTube channel to be able to use the integration. Instructions can be found at {support_url}.",
       "already_configured": "[%key:common::config_flow::abort::already_configured_account%]",
       "reauth_successful": "[%key:common::config_flow::abort::reauth_successful%]",
       "unknown": "[%key:common::config_flow::error::unknown%]"
diff --git a/tests/components/youtube/fixtures/get_no_channel.json b/tests/components/youtube/fixtures/get_no_channel.json
new file mode 100644
index 00000000000..7ec03c0461a
--- /dev/null
+++ b/tests/components/youtube/fixtures/get_no_channel.json
@@ -0,0 +1,9 @@
+{
+  "kind": "youtube#channelListResponse",
+  "etag": "8HTiiXpKCq-GJvDVOd88e5o_KGc",
+  "pageInfo": {
+    "totalResults": 0,
+    "resultsPerPage": 5
+  },
+  "items": []
+}
diff --git a/tests/components/youtube/test_config_flow.py b/tests/components/youtube/test_config_flow.py
index ed33947b593..5b91ff958f8 100644
--- a/tests/components/youtube/test_config_flow.py
+++ b/tests/components/youtube/test_config_flow.py
@@ -83,6 +83,46 @@ async def test_full_flow(
     assert result["options"] == {CONF_CHANNELS: ["UC_x5XG1OV2P6uZZ5FSM9Ttw"]}
 
 
+async def test_flow_abort_without_channel(
+    hass: HomeAssistant,
+    hass_client_no_auth: ClientSessionGenerator,
+    current_request_with_host: None,
+) -> None:
+    """Check abort flow if user has no channel."""
+    result = await hass.config_entries.flow.async_init(
+        "youtube", context={"source": config_entries.SOURCE_USER}
+    )
+    state = config_entry_oauth2_flow._encode_jwt(
+        hass,
+        {
+            "flow_id": result["flow_id"],
+            "redirect_uri": "https://example.com/auth/external/callback",
+        },
+    )
+
+    assert result["url"] == (
+        f"{GOOGLE_AUTH_URI}?response_type=code&client_id={CLIENT_ID}"
+        "&redirect_uri=https://example.com/auth/external/callback"
+        f"&state={state}&scope={'+'.join(SCOPES)}"
+        "&access_type=offline&prompt=consent"
+    )
+
+    client = await hass_client_no_auth()
+    resp = await client.get(f"/auth/external/callback?code=abcd&state={state}")
+    assert resp.status == 200
+    assert resp.headers["content-type"] == "text/html; charset=utf-8"
+
+    service = MockService(channel_fixture="youtube/get_no_channel.json")
+    with patch(
+        "homeassistant.components.youtube.async_setup_entry", return_value=True
+    ), patch("homeassistant.components.youtube.api.build", return_value=service), patch(
+        "homeassistant.components.youtube.config_flow.build", return_value=service
+    ):
+        result = await hass.config_entries.flow.async_configure(result["flow_id"])
+        assert result["type"] == FlowResultType.ABORT
+        assert result["reason"] == "no_channel"
+
+
 async def test_flow_http_error(
     hass: HomeAssistant,
     hass_client_no_auth: ClientSessionGenerator,