diff --git a/homeassistant/components/usb/__init__.py b/homeassistant/components/usb/__init__.py
index 36a63a36642..3aaccc15a64 100644
--- a/homeassistant/components/usb/__init__.py
+++ b/homeassistant/components/usb/__init__.py
@@ -15,6 +15,7 @@ from homeassistant.components import websocket_api
 from homeassistant.components.websocket_api.connection import ActiveConnection
 from homeassistant.const import EVENT_HOMEASSISTANT_STARTED, EVENT_HOMEASSISTANT_STOP
 from homeassistant.core import Event, HomeAssistant, callback
+from homeassistant.helpers import system_info
 from homeassistant.helpers.debounce import Debouncer
 from homeassistant.helpers.typing import ConfigType
 from homeassistant.loader import async_get_usb
@@ -102,6 +103,10 @@ class USBDiscovery:
         """Start monitoring hardware with pyudev."""
         if not sys.platform.startswith("linux"):
             return
+        info = await system_info.async_get_system_info(self.hass)
+        if info.get("docker") and not info.get("hassio"):
+            return
+
         from pyudev import (  # pylint: disable=import-outside-toplevel
             Context,
             Monitor,
diff --git a/tests/components/usb/test_init.py b/tests/components/usb/test_init.py
index a290ef9fa4c..9c480f11fc6 100644
--- a/tests/components/usb/test_init.py
+++ b/tests/components/usb/test_init.py
@@ -12,11 +12,37 @@ from homeassistant.setup import async_setup_component
 from . import slae_sh_device
 
 
+@pytest.fixture(name="operating_system")
+def mock_operating_system():
+    """Mock running Home Assistant Operating system."""
+    with patch(
+        "homeassistant.components.usb.system_info.async_get_system_info",
+        return_value={
+            "hassio": True,
+            "docker": True,
+        },
+    ):
+        yield
+
+
+@pytest.fixture(name="docker")
+def mock_docker():
+    """Mock running Home Assistant in docker container."""
+    with patch(
+        "homeassistant.components.usb.system_info.async_get_system_info",
+        return_value={
+            "hassio": False,
+            "docker": True,
+        },
+    ):
+        yield
+
+
 @pytest.mark.skipif(
     not sys.platform.startswith("linux"),
     reason="Only works on linux",
 )
-async def test_discovered_by_observer_before_started(hass):
+async def test_discovered_by_observer_before_started(hass, operating_system):
     """Test a device is discovered by the observer before started."""
 
     async def _mock_monitor_observer_callback(callback):
@@ -65,7 +91,7 @@ async def test_discovered_by_observer_before_started(hass):
     not sys.platform.startswith("linux"),
     reason="Only works on linux",
 )
-async def test_removal_by_observer_before_started(hass):
+async def test_removal_by_observer_before_started(hass, operating_system):
     """Test a device is removed by the observer before started."""
 
     async def _mock_monitor_observer_callback(callback):
@@ -289,6 +315,54 @@ async def test_non_matching_discovered_by_scanner_after_started(
     assert len(mock_config_flow.mock_calls) == 0
 
 
+@pytest.mark.skipif(
+    not sys.platform.startswith("linux"),
+    reason="Only works on linux",
+)
+async def test_not_discovered_by_observer_before_started_on_docker(hass, docker):
+    """Test a device is not discovered since observer is not running on bare docker."""
+
+    async def _mock_monitor_observer_callback(callback):
+        await hass.async_add_executor_job(
+            callback, MagicMock(action="add", device_path="/dev/new")
+        )
+
+    def _create_mock_monitor_observer(monitor, callback, name):
+        hass.async_create_task(_mock_monitor_observer_callback(callback))
+        return MagicMock()
+
+    new_usb = [{"domain": "test1", "vid": "3039", "pid": "3039"}]
+
+    mock_comports = [
+        MagicMock(
+            device=slae_sh_device.device,
+            vid=12345,
+            pid=12345,
+            serial_number=slae_sh_device.serial_number,
+            manufacturer=slae_sh_device.manufacturer,
+            description=slae_sh_device.description,
+        )
+    ]
+
+    with patch(
+        "homeassistant.components.usb.async_get_usb", return_value=new_usb
+    ), patch(
+        "homeassistant.components.usb.comports", return_value=mock_comports
+    ), patch(
+        "pyudev.MonitorObserver", new=_create_mock_monitor_observer
+    ):
+        assert await async_setup_component(hass, "usb", {"usb": {}})
+        await hass.async_block_till_done()
+
+    with patch("homeassistant.components.usb.comports", return_value=[]), patch.object(
+        hass.config_entries.flow, "async_init"
+    ) as mock_config_flow:
+        hass.bus.async_fire(EVENT_HOMEASSISTANT_STARTED)
+        await hass.async_block_till_done()
+
+    assert len(mock_config_flow.mock_calls) == 0
+
+
 def test_get_serial_by_id_no_dir():
     """Test serial by id conversion if there's no /dev/serial/by-id."""
     p1 = patch("os.path.isdir", MagicMock(return_value=False))