diff --git a/homeassistant/components/anthropic/__init__.py b/homeassistant/components/anthropic/__init__.py
index aa6cf509fa1..84c9054b476 100644
--- a/homeassistant/components/anthropic/__init__.py
+++ b/homeassistant/components/anthropic/__init__.py
@@ -2,6 +2,8 @@
 
 from __future__ import annotations
 
+from functools import partial
+
 import anthropic
 
 from homeassistant.config_entries import ConfigEntry
@@ -20,7 +22,9 @@ type AnthropicConfigEntry = ConfigEntry[anthropic.AsyncClient]
 
 async def async_setup_entry(hass: HomeAssistant, entry: AnthropicConfigEntry) -> bool:
     """Set up Anthropic from a config entry."""
-    client = anthropic.AsyncAnthropic(api_key=entry.data[CONF_API_KEY])
+    client = await hass.async_add_executor_job(
+        partial(anthropic.AsyncAnthropic, api_key=entry.data[CONF_API_KEY])
+    )
     try:
         await client.messages.create(
             model="claude-3-haiku-20240307",
diff --git a/homeassistant/components/anthropic/config_flow.py b/homeassistant/components/anthropic/config_flow.py
index fa43a3c4bcc..63a70f31fea 100644
--- a/homeassistant/components/anthropic/config_flow.py
+++ b/homeassistant/components/anthropic/config_flow.py
@@ -2,6 +2,7 @@
 
 from __future__ import annotations
 
+from functools import partial
 import logging
 from types import MappingProxyType
 from typing import Any
@@ -59,7 +60,9 @@ async def validate_input(hass: HomeAssistant, data: dict[str, Any]) -> None:
 
     Data has the keys from STEP_USER_DATA_SCHEMA with values provided by the user.
     """
-    client = anthropic.AsyncAnthropic(api_key=data[CONF_API_KEY])
+    client = await hass.async_add_executor_job(
+        partial(anthropic.AsyncAnthropic, api_key=data[CONF_API_KEY])
+    )
     await client.messages.create(
         model="claude-3-haiku-20240307",
         max_tokens=1,
diff --git a/tests/components/anthropic/test_conversation.py b/tests/components/anthropic/test_conversation.py
index bda9ca32b34..a35df281fb6 100644
--- a/tests/components/anthropic/test_conversation.py
+++ b/tests/components/anthropic/test_conversation.py
@@ -488,6 +488,7 @@ async def test_unknown_hass_api(
             CONF_LLM_HASS_API: "non-existing",
         },
     )
+    await hass.async_block_till_done()
 
     result = await conversation.async_converse(
         hass, "hello", "1234", Context(), agent_id="conversation.claude"