diff --git a/homeassistant/components/zha/core/gateway.py b/homeassistant/components/zha/core/gateway.py
index f2fd226249b..14fbf2cf701 100644
--- a/homeassistant/components/zha/core/gateway.py
+++ b/homeassistant/components/zha/core/gateway.py
@@ -142,6 +142,7 @@ class ZHAGateway:
         self._log_relay_handler = LogRelayHandler(hass, self)
         self.config_entry = config_entry
         self._unsubs: list[Callable[[], None]] = []
+        self.initialized: bool = False
 
     async def async_initialize(self) -> None:
         """Initialize controller and connect radio."""
@@ -183,6 +184,7 @@ class ZHAGateway:
         self._hass.data[DATA_ZHA][DATA_ZHA_BRIDGE_ID] = str(self.coordinator_ieee)
         self.async_load_devices()
         self.async_load_groups()
+        self.initialized = True
 
     @callback
     def async_load_devices(self) -> None:
@@ -217,7 +219,7 @@ class ZHAGateway:
     async def async_initialize_devices_and_entities(self) -> None:
         """Initialize devices and load entities."""
 
-        _LOGGER.debug("Loading all devices")
+        _LOGGER.debug("Initializing all devices from Zigpy cache")
         await asyncio.gather(
             *(dev.async_initialize(from_cache=True) for dev in self.devices.values())
         )
diff --git a/homeassistant/components/zha/core/helpers.py b/homeassistant/components/zha/core/helpers.py
index b60f61b1e8e..7fd789ac3f5 100644
--- a/homeassistant/components/zha/core/helpers.py
+++ b/homeassistant/components/zha/core/helpers.py
@@ -26,6 +26,7 @@ import zigpy.zdo.types as zdo_types
 
 from homeassistant.config_entries import ConfigEntry
 from homeassistant.core import HomeAssistant, State, callback
+from homeassistant.exceptions import IntegrationError
 from homeassistant.helpers import device_registry as dr
 
 from .const import (
@@ -42,6 +43,7 @@ if TYPE_CHECKING:
     from .gateway import ZHAGateway
 
 _T = TypeVar("_T")
+_LOGGER = logging.getLogger(__name__)
 
 
 @dataclass
@@ -170,10 +172,22 @@ def async_get_zha_device(hass: HomeAssistant, device_id: str) -> ZHADevice:
     device_registry = dr.async_get(hass)
     registry_device = device_registry.async_get(device_id)
     if not registry_device:
+        _LOGGER.error("Device id `%s` not found in registry", device_id)
         raise KeyError(f"Device id `{device_id}` not found in registry.")
     zha_gateway: ZHAGateway = hass.data[DATA_ZHA][DATA_ZHA_GATEWAY]
-    ieee_address = list(list(registry_device.identifiers)[0])[1]
-    ieee = zigpy.types.EUI64.convert(ieee_address)
+    if not zha_gateway.initialized:
+        _LOGGER.error("Attempting to get a ZHA device when ZHA is not initialized")
+        raise IntegrationError("ZHA is not initialized yet")
+    try:
+        ieee_address = list(list(registry_device.identifiers)[0])[1]
+        ieee = zigpy.types.EUI64.convert(ieee_address)
+    except (IndexError, ValueError) as ex:
+        _LOGGER.error(
+            "Unable to determine device IEEE for device with device id `%s`", device_id
+        )
+        raise KeyError(
+            f"Unable to determine device IEEE for device with device id `{device_id}`."
+        ) from ex
     return zha_gateway.devices[ieee]
 
 
diff --git a/homeassistant/components/zha/device_trigger.py b/homeassistant/components/zha/device_trigger.py
index 44682aaa559..cdd98110f83 100644
--- a/homeassistant/components/zha/device_trigger.py
+++ b/homeassistant/components/zha/device_trigger.py
@@ -13,7 +13,7 @@ from homeassistant.components.device_automation.exceptions import (
 from homeassistant.components.homeassistant.triggers import event as event_trigger
 from homeassistant.const import CONF_DEVICE_ID, CONF_DOMAIN, CONF_PLATFORM, CONF_TYPE
 from homeassistant.core import CALLBACK_TYPE, HomeAssistant
-from homeassistant.exceptions import HomeAssistantError
+from homeassistant.exceptions import HomeAssistantError, IntegrationError
 from homeassistant.helpers.typing import ConfigType
 
 from . import DOMAIN
@@ -39,7 +39,7 @@ async def async_validate_trigger_config(
         trigger = (config[CONF_TYPE], config[CONF_SUBTYPE])
         try:
             zha_device = async_get_zha_device(hass, config[CONF_DEVICE_ID])
-        except (KeyError, AttributeError) as err:
+        except (KeyError, AttributeError, IntegrationError) as err:
             raise InvalidDeviceAutomationConfig from err
         if (
             zha_device.device_automation_triggers is None