diff --git a/homeassistant/components/raspberry_pi/__init__.py b/homeassistant/components/raspberry_pi/__init__.py
index 3750a1c7068..19697d9b69d 100644
--- a/homeassistant/components/raspberry_pi/__init__.py
+++ b/homeassistant/components/raspberry_pi/__init__.py
@@ -1,7 +1,7 @@
 """The Raspberry Pi integration."""
 from __future__ import annotations
 
-from homeassistant.components.hassio import get_os_info
+from homeassistant.components.hassio import get_os_info, is_hassio
 from homeassistant.config_entries import ConfigEntry
 from homeassistant.core import HomeAssistant
 from homeassistant.exceptions import ConfigEntryNotReady
@@ -9,6 +9,11 @@ from homeassistant.exceptions import ConfigEntryNotReady
 
 async def async_setup_entry(hass: HomeAssistant, entry: ConfigEntry) -> bool:
     """Set up a Raspberry Pi config entry."""
+    if not is_hassio(hass):
+        # Not running under supervisor, Home Assistant may have been migrated
+        hass.async_create_task(hass.config_entries.async_remove(entry.entry_id))
+        return False
+
     if (os_info := get_os_info(hass)) is None:
         # The hassio integration has not yet fetched data from the supervisor
         raise ConfigEntryNotReady
diff --git a/homeassistant/components/raspberry_pi/manifest.json b/homeassistant/components/raspberry_pi/manifest.json
index d30c637d2c3..5ed68154ce1 100644
--- a/homeassistant/components/raspberry_pi/manifest.json
+++ b/homeassistant/components/raspberry_pi/manifest.json
@@ -1,9 +1,10 @@
 {
   "domain": "raspberry_pi",
   "name": "Raspberry Pi",
+  "after_dependencies": ["hassio"],
   "codeowners": ["@home-assistant/core"],
   "config_flow": false,
-  "dependencies": ["hardware", "hassio"],
+  "dependencies": ["hardware"],
   "documentation": "https://www.home-assistant.io/integrations/raspberry_pi",
   "integration_type": "hardware"
 }
diff --git a/tests/components/raspberry_pi/test_hardware.py b/tests/components/raspberry_pi/test_hardware.py
index 77236040486..d41fbf2f5e1 100644
--- a/tests/components/raspberry_pi/test_hardware.py
+++ b/tests/components/raspberry_pi/test_hardware.py
@@ -3,8 +3,10 @@ from unittest.mock import patch
 
 import pytest
 
+from homeassistant.components.hassio import DOMAIN as HASSIO_DOMAIN
 from homeassistant.components.raspberry_pi.const import DOMAIN
 from homeassistant.core import HomeAssistant
+from homeassistant.setup import async_setup_component
 
 from tests.common import MockConfigEntry, MockModule, mock_integration
 from tests.typing import WebSocketGenerator
@@ -15,6 +17,7 @@ async def test_hardware_info(
 ) -> None:
     """Test we can get the board info."""
     mock_integration(hass, MockModule("hassio"))
+    await async_setup_component(hass, HASSIO_DOMAIN, {})
 
     # Setup the config entry
     config_entry = MockConfigEntry(
@@ -66,6 +69,7 @@ async def test_hardware_info_fail(
 ) -> None:
     """Test async_info raises if os_info is not as expected."""
     mock_integration(hass, MockModule("hassio"))
+    await async_setup_component(hass, HASSIO_DOMAIN, {})
 
     # Setup the config entry
     config_entry = MockConfigEntry(
diff --git a/tests/components/raspberry_pi/test_init.py b/tests/components/raspberry_pi/test_init.py
index b0e9ef89582..88518cc00b0 100644
--- a/tests/components/raspberry_pi/test_init.py
+++ b/tests/components/raspberry_pi/test_init.py
@@ -3,9 +3,11 @@ from unittest.mock import patch
 
 import pytest
 
+from homeassistant.components.hassio import DOMAIN as HASSIO_DOMAIN
 from homeassistant.components.raspberry_pi.const import DOMAIN
 from homeassistant.config_entries import ConfigEntryState
 from homeassistant.core import HomeAssistant
+from homeassistant.setup import async_setup_component
 
 from tests.common import MockConfigEntry, MockModule, mock_integration
 
@@ -23,6 +25,7 @@ def mock_rpi_power():
 async def test_setup_entry(hass: HomeAssistant) -> None:
     """Test setup of a config entry."""
     mock_integration(hass, MockModule("hassio"))
+    await async_setup_component(hass, HASSIO_DOMAIN, {})
 
     # Setup the config entry
     config_entry = MockConfigEntry(
@@ -46,9 +49,30 @@ async def test_setup_entry(hass: HomeAssistant) -> None:
     assert len(hass.config_entries.async_entries("rpi_power")) == 1
 
 
+async def test_setup_entry_no_hassio(hass: HomeAssistant) -> None:
+    """Test setup of a config entry without hassio."""
+    # Setup the config entry
+    config_entry = MockConfigEntry(
+        data={},
+        domain=DOMAIN,
+        options={},
+        title="Raspberry Pi",
+    )
+    config_entry.add_to_hass(hass)
+    assert len(hass.config_entries.async_entries()) == 1
+
+    with patch("homeassistant.components.raspberry_pi.get_os_info") as mock_get_os_info:
+        assert not await hass.config_entries.async_setup(config_entry.entry_id)
+        await hass.async_block_till_done()
+
+    assert len(mock_get_os_info.mock_calls) == 0
+    assert len(hass.config_entries.async_entries()) == 0
+
+
 async def test_setup_entry_wrong_board(hass: HomeAssistant) -> None:
     """Test setup of a config entry with wrong board type."""
     mock_integration(hass, MockModule("hassio"))
+    await async_setup_component(hass, HASSIO_DOMAIN, {})
 
     # Setup the config entry
     config_entry = MockConfigEntry(
@@ -74,6 +98,7 @@ async def test_setup_entry_wrong_board(hass: HomeAssistant) -> None:
 async def test_setup_entry_wait_hassio(hass: HomeAssistant) -> None:
     """Test setup of a config entry when hassio has not fetched os_info."""
     mock_integration(hass, MockModule("hassio"))
+    await async_setup_component(hass, HASSIO_DOMAIN, {})
 
     # Setup the config entry
     config_entry = MockConfigEntry(