diff --git a/homeassistant/components/serial/manifest.json b/homeassistant/components/serial/manifest.json
index c87221cce54..2964ea362fd 100644
--- a/homeassistant/components/serial/manifest.json
+++ b/homeassistant/components/serial/manifest.json
@@ -2,7 +2,7 @@
   "domain": "serial",
   "name": "Serial",
   "documentation": "https://www.home-assistant.io/integrations/serial",
-  "requirements": ["pyserial-asyncio==0.5"],
+  "requirements": ["pyserial-asyncio==0.6"],
   "codeowners": ["@fabaff"],
   "iot_class": "local_polling"
 }
diff --git a/homeassistant/components/zha/manifest.json b/homeassistant/components/zha/manifest.json
index f3a7f4e3755..7766406c9b4 100644
--- a/homeassistant/components/zha/manifest.json
+++ b/homeassistant/components/zha/manifest.json
@@ -6,7 +6,7 @@
   "requirements": [
     "bellows==0.29.0",
     "pyserial==3.5",
-    "pyserial-asyncio==0.5",
+    "pyserial-asyncio==0.6",
     "zha-quirks==0.0.65",
     "zigpy-deconz==0.14.0",
     "zigpy==0.42.0",
diff --git a/requirements_all.txt b/requirements_all.txt
index 6c06f83d14b..c5a84b01f74 100644
--- a/requirements_all.txt
+++ b/requirements_all.txt
@@ -1813,7 +1813,7 @@ pysensibo==1.0.3
 
 # homeassistant.components.serial
 # homeassistant.components.zha
-pyserial-asyncio==0.5
+pyserial-asyncio==0.6
 
 # homeassistant.components.acer_projector
 # homeassistant.components.crownstone
diff --git a/requirements_test_all.txt b/requirements_test_all.txt
index 3ace9c03128..0574893e6d2 100644
--- a/requirements_test_all.txt
+++ b/requirements_test_all.txt
@@ -1140,7 +1140,7 @@ pysensibo==1.0.3
 
 # homeassistant.components.serial
 # homeassistant.components.zha
-pyserial-asyncio==0.5
+pyserial-asyncio==0.6
 
 # homeassistant.components.acer_projector
 # homeassistant.components.crownstone