diff --git a/homeassistant/components/ista_ecotrend/__init__.py b/homeassistant/components/ista_ecotrend/__init__.py
index 7650f0d5f18..4b698139260 100644
--- a/homeassistant/components/ista_ecotrend/__init__.py
+++ b/homeassistant/components/ista_ecotrend/__init__.py
@@ -6,6 +6,7 @@ import logging
 
 from pyecotrend_ista import PyEcotrendIsta
 
+from homeassistant.components.recorder import get_instance
 from homeassistant.const import CONF_EMAIL, CONF_PASSWORD, Platform
 from homeassistant.core import HomeAssistant
 
@@ -37,3 +38,9 @@ async def async_setup_entry(hass: HomeAssistant, entry: IstaConfigEntry) -> bool
 async def async_unload_entry(hass: HomeAssistant, entry: IstaConfigEntry) -> bool:
     """Unload a config entry."""
     return await hass.config_entries.async_unload_platforms(entry, PLATFORMS)
+
+
+async def async_remove_entry(hass: HomeAssistant, entry: IstaConfigEntry) -> None:
+    """Handle removal of an entry."""
+    statistic_ids = [f"{DOMAIN}:{name}" for name in entry.options.values()]
+    get_instance(hass).async_clear_statistics(statistic_ids)
diff --git a/tests/components/ista_ecotrend/test_statistics.py b/tests/components/ista_ecotrend/test_statistics.py
index aa4f71037c4..b5f419437c5 100644
--- a/tests/components/ista_ecotrend/test_statistics.py
+++ b/tests/components/ista_ecotrend/test_statistics.py
@@ -84,3 +84,61 @@ async def test_statistics_import(
         assert stats[statistic_id] == snapshot(name=f"{statistic_id}_3months")
 
         assert len(stats[statistic_id]) == 3
+
+
+@pytest.mark.usefixtures("recorder_mock", "mock_ista")
+async def test_remove(
+    hass: HomeAssistant,
+    ista_config_entry: MockConfigEntry,
+) -> None:
+    """Test remove config entry and clear statistics."""
+    ista_config_entry.add_to_hass(hass)
+    await hass.config_entries.async_setup(ista_config_entry.entry_id)
+    await hass.async_block_till_done()
+
+    assert ista_config_entry.state is ConfigEntryState.LOADED
+    await async_wait_recording_done(hass)
+
+    assert await hass.async_add_executor_job(
+        statistics_during_period,
+        hass,
+        datetime.datetime.fromtimestamp(0, tz=datetime.UTC),
+        None,
+        {"ista_ecotrend:bahnhofsstr_1a_heating"},
+        "month",
+        None,
+        {"state", "sum"},
+    )
+
+    assert await hass.config_entries.async_unload(ista_config_entry.entry_id)
+    await hass.async_block_till_done()
+
+    assert ista_config_entry.state is ConfigEntryState.NOT_LOADED
+    await async_wait_recording_done(hass)
+
+    assert await hass.async_add_executor_job(
+        statistics_during_period,
+        hass,
+        datetime.datetime.fromtimestamp(0, tz=datetime.UTC),
+        None,
+        {"ista_ecotrend:bahnhofsstr_1a_heating"},
+        "month",
+        None,
+        {"state", "sum"},
+    )
+
+    assert await hass.config_entries.async_remove(ista_config_entry.entry_id)
+    await hass.async_block_till_done()
+
+    await async_wait_recording_done(hass)
+
+    assert not await hass.async_add_executor_job(
+        statistics_during_period,
+        hass,
+        datetime.datetime.fromtimestamp(0, tz=datetime.UTC),
+        None,
+        {"ista_ecotrend:bahnhofsstr_1a_heating"},
+        "month",
+        None,
+        {"state", "sum"},
+    )