diff --git a/homeassistant/components/isy994/__init__.py b/homeassistant/components/isy994/__init__.py
index 1e227b08206..bed86b2d0fe 100644
--- a/homeassistant/components/isy994/__init__.py
+++ b/homeassistant/components/isy994/__init__.py
@@ -10,7 +10,6 @@ from pyisy import ISY, ISYConnectionError, ISYInvalidAuthError, ISYResponseParse
 from pyisy.constants import CONFIG_NETWORKING, CONFIG_PORTAL
 import voluptuous as vol
 
-from homeassistant import config_entries
 from homeassistant.const import (
     CONF_HOST,
     CONF_PASSWORD,
@@ -46,7 +45,7 @@ from .const import (
     SCHEME_HTTPS,
 )
 from .helpers import _categorize_nodes, _categorize_programs
-from .models import IsyData
+from .models import IsyConfigEntry, IsyData
 from .services import async_setup_services, async_unload_services
 from .util import _async_cleanup_registry_entries
 
@@ -56,13 +55,8 @@ CONFIG_SCHEMA = vol.Schema(
 )
 
 
-async def async_setup_entry(
-    hass: HomeAssistant, entry: config_entries.ConfigEntry
-) -> bool:
+async def async_setup_entry(hass: HomeAssistant, entry: IsyConfigEntry) -> bool:
     """Set up the ISY 994 integration."""
-    hass.data.setdefault(DOMAIN, {})
-    isy_data = hass.data[DOMAIN][entry.entry_id] = IsyData()
-
     isy_config = entry.data
     isy_options = entry.options
 
@@ -127,6 +121,7 @@ async def async_setup_entry(
             f"Invalid response ISY, device is likely still starting: {err}"
         ) from err
 
+    isy_data = entry.runtime_data = IsyData()
     _categorize_nodes(isy_data, isy.nodes, ignore_identifier, sensor_identifier)
     _categorize_programs(isy_data, isy.programs)
     # Gather ISY Variables to be added.
@@ -156,7 +151,7 @@ async def async_setup_entry(
     await hass.config_entries.async_forward_entry_setups(entry, PLATFORMS)
 
     # Clean-up any old entities that we no longer provide.
-    _async_cleanup_registry_entries(hass, entry.entry_id)
+    _async_cleanup_registry_entries(hass, entry)
 
     @callback
     def _async_stop_auto_update(event: Event) -> None:
@@ -178,16 +173,14 @@ async def async_setup_entry(
     return True
 
 
-async def _async_update_listener(
-    hass: HomeAssistant, entry: config_entries.ConfigEntry
-) -> None:
+async def _async_update_listener(hass: HomeAssistant, entry: IsyConfigEntry) -> None:
     """Handle options update."""
     await hass.config_entries.async_reload(entry.entry_id)
 
 
 @callback
 def _async_get_or_create_isy_device_in_registry(
-    hass: HomeAssistant, entry: config_entries.ConfigEntry, isy: ISY
+    hass: HomeAssistant, entry: IsyConfigEntry, isy: ISY
 ) -> None:
     device_registry = dr.async_get(hass)
     device_registry.async_get_or_create(
@@ -221,34 +214,25 @@ def _create_service_device_info(isy: ISY, name: str, unique_id: str) -> DeviceIn
     )
 
 
-async def async_unload_entry(
-    hass: HomeAssistant, entry: config_entries.ConfigEntry
-) -> bool:
+async def async_unload_entry(hass: HomeAssistant, entry: IsyConfigEntry) -> bool:
     """Unload a config entry."""
     unload_ok = await hass.config_entries.async_unload_platforms(entry, PLATFORMS)
 
-    isy_data: IsyData = hass.data[DOMAIN][entry.entry_id]
-
-    isy = isy_data.root
-
     _LOGGER.debug("ISY Stopping Event Stream and automatic updates")
-    isy.websocket.stop()
+    entry.runtime_data.root.websocket.stop()
 
-    if unload_ok:
-        hass.data[DOMAIN].pop(entry.entry_id)
-
-    async_unload_services(hass)
+    if not hass.config_entries.async_loaded_entries(DOMAIN):
+        async_unload_services(hass)
 
     return unload_ok
 
 
 async def async_remove_config_entry_device(
     hass: HomeAssistant,
-    config_entry: config_entries.ConfigEntry,
+    config_entry: IsyConfigEntry,
     device_entry: dr.DeviceEntry,
 ) -> bool:
     """Remove ISY config entry from a device."""
-    isy_data = hass.data[DOMAIN][config_entry.entry_id]
     return not device_entry.identifiers.intersection(
-        (DOMAIN, unique_id) for unique_id in isy_data.devices
+        (DOMAIN, unique_id) for unique_id in config_entry.runtime_data.devices
     )
diff --git a/homeassistant/components/isy994/binary_sensor.py b/homeassistant/components/isy994/binary_sensor.py
index 8c9ce7dcc12..d452b5bacef 100644
--- a/homeassistant/components/isy994/binary_sensor.py
+++ b/homeassistant/components/isy994/binary_sensor.py
@@ -19,7 +19,6 @@ from homeassistant.components.binary_sensor import (
     BinarySensorDeviceClass,
     BinarySensorEntity,
 )
-from homeassistant.config_entries import ConfigEntry
 from homeassistant.const import STATE_ON, Platform
 from homeassistant.core import CALLBACK_TYPE, HomeAssistant, callback
 from homeassistant.helpers.device_registry import DeviceInfo
@@ -31,7 +30,6 @@ from .const import (
     _LOGGER,
     BINARY_SENSOR_DEVICE_TYPES_ISY,
     BINARY_SENSOR_DEVICE_TYPES_ZWAVE,
-    DOMAIN,
     SUBNODE_CLIMATE_COOL,
     SUBNODE_CLIMATE_HEAT,
     SUBNODE_DUSK_DAWN,
@@ -44,7 +42,7 @@ from .const import (
     TYPE_INSTEON_MOTION,
 )
 from .entity import ISYNodeEntity, ISYProgramEntity
-from .models import IsyData
+from .models import IsyConfigEntry
 
 DEVICE_PARENT_REQUIRED = [
     BinarySensorDeviceClass.OPENING,
@@ -55,7 +53,7 @@ DEVICE_PARENT_REQUIRED = [
 
 async def async_setup_entry(
     hass: HomeAssistant,
-    entry: ConfigEntry,
+    entry: IsyConfigEntry,
     async_add_entities: AddConfigEntryEntitiesCallback,
 ) -> None:
     """Set up the ISY binary sensor platform."""
@@ -82,8 +80,8 @@ async def async_setup_entry(
         | ISYBinarySensorProgramEntity
     )
 
-    isy_data: IsyData = hass.data[DOMAIN][entry.entry_id]
-    devices: dict[str, DeviceInfo] = isy_data.devices
+    isy_data = entry.runtime_data
+    devices = isy_data.devices
     for node in isy_data.nodes[Platform.BINARY_SENSOR]:
         assert isinstance(node, Node)
         device_info = devices.get(node.primary_node)
diff --git a/homeassistant/components/isy994/button.py b/homeassistant/components/isy994/button.py
index a895312c45a..cfb077c7dc0 100644
--- a/homeassistant/components/isy994/button.py
+++ b/homeassistant/components/isy994/button.py
@@ -15,24 +15,23 @@ from pyisy.networking import NetworkCommand
 from pyisy.nodes import Node
 
 from homeassistant.components.button import ButtonEntity
-from homeassistant.config_entries import ConfigEntry
 from homeassistant.const import EntityCategory, Platform
 from homeassistant.core import HomeAssistant, callback
 from homeassistant.helpers.device_registry import DeviceInfo
 from homeassistant.helpers.entity_platform import AddConfigEntryEntitiesCallback
 
 from .const import CONF_NETWORK, DOMAIN
-from .models import IsyData
+from .models import IsyConfigEntry
 
 
 async def async_setup_entry(
     hass: HomeAssistant,
-    config_entry: ConfigEntry,
+    config_entry: IsyConfigEntry,
     async_add_entities: AddConfigEntryEntitiesCallback,
 ) -> None:
     """Set up ISY/IoX button from config entry."""
-    isy_data: IsyData = hass.data[DOMAIN][config_entry.entry_id]
-    isy: ISY = isy_data.root
+    isy_data = config_entry.runtime_data
+    isy = isy_data.root
     device_info = isy_data.devices
     entities: list[
         ISYNodeQueryButtonEntity
diff --git a/homeassistant/components/isy994/climate.py b/homeassistant/components/isy994/climate.py
index 57c1b6aa79d..ce39cae5428 100644
--- a/homeassistant/components/isy994/climate.py
+++ b/homeassistant/components/isy994/climate.py
@@ -28,7 +28,6 @@ from homeassistant.components.climate import (
     HVACAction,
     HVACMode,
 )
-from homeassistant.config_entries import ConfigEntry
 from homeassistant.const import (
     ATTR_TEMPERATURE,
     PRECISION_TENTHS,
@@ -42,7 +41,6 @@ from homeassistant.util.enum import try_parse_enum
 
 from .const import (
     _LOGGER,
-    DOMAIN,
     HA_FAN_TO_ISY,
     HA_HVAC_TO_ISY,
     ISY_HVAC_MODES,
@@ -57,18 +55,18 @@ from .const import (
 )
 from .entity import ISYNodeEntity
 from .helpers import convert_isy_value_to_hass
-from .models import IsyData
+from .models import IsyConfigEntry
 
 
 async def async_setup_entry(
     hass: HomeAssistant,
-    entry: ConfigEntry,
+    entry: IsyConfigEntry,
     async_add_entities: AddConfigEntryEntitiesCallback,
 ) -> None:
     """Set up the ISY thermostat platform."""
 
-    isy_data: IsyData = hass.data[DOMAIN][entry.entry_id]
-    devices: dict[str, DeviceInfo] = isy_data.devices
+    isy_data = entry.runtime_data
+    devices = isy_data.devices
 
     async_add_entities(
         ISYThermostatEntity(node, devices.get(node.primary_node))
diff --git a/homeassistant/components/isy994/config_flow.py b/homeassistant/components/isy994/config_flow.py
index b44096e2ccd..2acebee8599 100644
--- a/homeassistant/components/isy994/config_flow.py
+++ b/homeassistant/components/isy994/config_flow.py
@@ -16,7 +16,6 @@ import voluptuous as vol
 
 from homeassistant.config_entries import (
     SOURCE_IGNORE,
-    ConfigEntry,
     ConfigFlow,
     ConfigFlowResult,
     OptionsFlow,
@@ -54,6 +53,7 @@ from .const import (
     SCHEME_HTTPS,
     UDN_UUID_PREFIX,
 )
+from .models import IsyConfigEntry
 
 _LOGGER = logging.getLogger(__name__)
 
@@ -137,12 +137,12 @@ class Isy994ConfigFlow(ConfigFlow, domain=DOMAIN):
     def __init__(self) -> None:
         """Initialize the ISY/IoX config flow."""
         self.discovered_conf: dict[str, str] = {}
-        self._existing_entry: ConfigEntry | None = None
+        self._existing_entry: IsyConfigEntry | None = None
 
     @staticmethod
     @callback
     def async_get_options_flow(
-        config_entry: ConfigEntry,
+        config_entry: IsyConfigEntry,
     ) -> OptionsFlow:
         """Get the options flow for this handler."""
         return OptionsFlowHandler()
diff --git a/homeassistant/components/isy994/cover.py b/homeassistant/components/isy994/cover.py
index 6a660aaaf6f..f940fe55332 100644
--- a/homeassistant/components/isy994/cover.py
+++ b/homeassistant/components/isy994/cover.py
@@ -11,25 +11,23 @@ from homeassistant.components.cover import (
     CoverEntity,
     CoverEntityFeature,
 )
-from homeassistant.config_entries import ConfigEntry
 from homeassistant.const import Platform
 from homeassistant.core import HomeAssistant
-from homeassistant.helpers.device_registry import DeviceInfo
 from homeassistant.helpers.entity_platform import AddConfigEntryEntitiesCallback
 
-from .const import _LOGGER, DOMAIN, UOM_8_BIT_RANGE
+from .const import _LOGGER, UOM_8_BIT_RANGE
 from .entity import ISYNodeEntity, ISYProgramEntity
-from .models import IsyData
+from .models import IsyConfigEntry
 
 
 async def async_setup_entry(
     hass: HomeAssistant,
-    entry: ConfigEntry,
+    entry: IsyConfigEntry,
     async_add_entities: AddConfigEntryEntitiesCallback,
 ) -> None:
     """Set up the ISY cover platform."""
-    isy_data: IsyData = hass.data[DOMAIN][entry.entry_id]
-    devices: dict[str, DeviceInfo] = isy_data.devices
+    isy_data = entry.runtime_data
+    devices = isy_data.devices
     entities: list[ISYCoverEntity | ISYCoverProgramEntity] = [
         ISYCoverEntity(node, devices.get(node.primary_node))
         for node in isy_data.nodes[Platform.COVER]
diff --git a/homeassistant/components/isy994/fan.py b/homeassistant/components/isy994/fan.py
index aa6059abf49..02542462788 100644
--- a/homeassistant/components/isy994/fan.py
+++ b/homeassistant/components/isy994/fan.py
@@ -8,10 +8,8 @@ from typing import Any
 from pyisy.constants import ISY_VALUE_UNKNOWN, PROTO_INSTEON
 
 from homeassistant.components.fan import FanEntity, FanEntityFeature
-from homeassistant.config_entries import ConfigEntry
 from homeassistant.const import Platform
 from homeassistant.core import HomeAssistant
-from homeassistant.helpers.device_registry import DeviceInfo
 from homeassistant.helpers.entity_platform import AddConfigEntryEntitiesCallback
 from homeassistant.util.percentage import (
     percentage_to_ranged_value,
@@ -19,21 +17,21 @@ from homeassistant.util.percentage import (
 )
 from homeassistant.util.scaling import int_states_in_range
 
-from .const import _LOGGER, DOMAIN
+from .const import _LOGGER
 from .entity import ISYNodeEntity, ISYProgramEntity
-from .models import IsyData
+from .models import IsyConfigEntry
 
 SPEED_RANGE = (1, 255)  # off is not included
 
 
 async def async_setup_entry(
     hass: HomeAssistant,
-    entry: ConfigEntry,
+    entry: IsyConfigEntry,
     async_add_entities: AddConfigEntryEntitiesCallback,
 ) -> None:
     """Set up the ISY fan platform."""
-    isy_data: IsyData = hass.data[DOMAIN][entry.entry_id]
-    devices: dict[str, DeviceInfo] = isy_data.devices
+    isy_data = entry.runtime_data
+    devices = isy_data.devices
     entities: list[ISYFanEntity | ISYFanProgramEntity] = [
         ISYFanEntity(node, devices.get(node.primary_node))
         for node in isy_data.nodes[Platform.FAN]
diff --git a/homeassistant/components/isy994/light.py b/homeassistant/components/isy994/light.py
index 29df8398f97..d3edc25c3e2 100644
--- a/homeassistant/components/isy994/light.py
+++ b/homeassistant/components/isy994/light.py
@@ -9,28 +9,27 @@ from pyisy.helpers import NodeProperty
 from pyisy.nodes import Node
 
 from homeassistant.components.light import ColorMode, LightEntity
-from homeassistant.config_entries import ConfigEntry
 from homeassistant.const import Platform
 from homeassistant.core import HomeAssistant, callback
 from homeassistant.helpers.device_registry import DeviceInfo
 from homeassistant.helpers.entity_platform import AddConfigEntryEntitiesCallback
 from homeassistant.helpers.restore_state import RestoreEntity
 
-from .const import _LOGGER, CONF_RESTORE_LIGHT_STATE, DOMAIN, UOM_PERCENTAGE
+from .const import _LOGGER, CONF_RESTORE_LIGHT_STATE, UOM_PERCENTAGE
 from .entity import ISYNodeEntity
-from .models import IsyData
+from .models import IsyConfigEntry
 
 ATTR_LAST_BRIGHTNESS = "last_brightness"
 
 
 async def async_setup_entry(
     hass: HomeAssistant,
-    entry: ConfigEntry,
+    entry: IsyConfigEntry,
     async_add_entities: AddConfigEntryEntitiesCallback,
 ) -> None:
     """Set up the ISY light platform."""
-    isy_data: IsyData = hass.data[DOMAIN][entry.entry_id]
-    devices: dict[str, DeviceInfo] = isy_data.devices
+    isy_data = entry.runtime_data
+    devices = isy_data.devices
     isy_options = entry.options
     restore_light_state = isy_options.get(CONF_RESTORE_LIGHT_STATE, False)
 
diff --git a/homeassistant/components/isy994/lock.py b/homeassistant/components/isy994/lock.py
index d6866a8e00c..056d1d0d492 100644
--- a/homeassistant/components/isy994/lock.py
+++ b/homeassistant/components/isy994/lock.py
@@ -7,19 +7,16 @@ from typing import Any
 from pyisy.constants import ISY_VALUE_UNKNOWN
 
 from homeassistant.components.lock import LockEntity
-from homeassistant.config_entries import ConfigEntry
 from homeassistant.const import Platform
 from homeassistant.core import HomeAssistant, callback
 from homeassistant.exceptions import HomeAssistantError
-from homeassistant.helpers.device_registry import DeviceInfo
 from homeassistant.helpers.entity_platform import (
     AddConfigEntryEntitiesCallback,
     async_get_current_platform,
 )
 
-from .const import DOMAIN
 from .entity import ISYNodeEntity, ISYProgramEntity
-from .models import IsyData
+from .models import IsyConfigEntry
 from .services import (
     SERVICE_DELETE_USER_CODE_SCHEMA,
     SERVICE_DELETE_ZWAVE_LOCK_USER_CODE,
@@ -49,12 +46,12 @@ def async_setup_lock_services(hass: HomeAssistant) -> None:
 
 async def async_setup_entry(
     hass: HomeAssistant,
-    entry: ConfigEntry,
+    entry: IsyConfigEntry,
     async_add_entities: AddConfigEntryEntitiesCallback,
 ) -> None:
     """Set up the ISY lock platform."""
-    isy_data: IsyData = hass.data[DOMAIN][entry.entry_id]
-    devices: dict[str, DeviceInfo] = isy_data.devices
+    isy_data = entry.runtime_data
+    devices = isy_data.devices
     entities: list[ISYLockEntity | ISYLockProgramEntity] = [
         ISYLockEntity(node, devices.get(node.primary_node))
         for node in isy_data.nodes[Platform.LOCK]
diff --git a/homeassistant/components/isy994/models.py b/homeassistant/components/isy994/models.py
index 5b599df9458..4fc7b96fcd5 100644
--- a/homeassistant/components/isy994/models.py
+++ b/homeassistant/components/isy994/models.py
@@ -12,6 +12,7 @@ from pyisy.nodes import Group, Node
 from pyisy.programs import Program
 from pyisy.variables import Variable
 
+from homeassistant.config_entries import ConfigEntry
 from homeassistant.const import Platform
 from homeassistant.helpers.device_registry import DeviceInfo
 
@@ -24,6 +25,8 @@ from .const import (
     VARIABLE_PLATFORMS,
 )
 
+type IsyConfigEntry = ConfigEntry[IsyData]
+
 
 @dataclass
 class IsyData:
diff --git a/homeassistant/components/isy994/number.py b/homeassistant/components/isy994/number.py
index fc30e6296d4..c5797491e31 100644
--- a/homeassistant/components/isy994/number.py
+++ b/homeassistant/components/isy994/number.py
@@ -26,7 +26,6 @@ from homeassistant.components.number import (
     NumberMode,
     RestoreNumber,
 )
-from homeassistant.config_entries import ConfigEntry
 from homeassistant.const import (
     CONF_VARIABLES,
     PERCENTAGE,
@@ -44,15 +43,10 @@ from homeassistant.util.percentage import (
     ranged_value_to_percentage,
 )
 
-from .const import (
-    CONF_VAR_SENSOR_STRING,
-    DEFAULT_VAR_SENSOR_STRING,
-    DOMAIN,
-    UOM_8_BIT_RANGE,
-)
+from .const import CONF_VAR_SENSOR_STRING, DEFAULT_VAR_SENSOR_STRING, UOM_8_BIT_RANGE
 from .entity import ISYAuxControlEntity
 from .helpers import convert_isy_value_to_hass
-from .models import IsyData
+from .models import IsyConfigEntry
 
 ISY_MAX_SIZE = (2**32) / 2
 ON_RANGE = (1, 255)  # Off is not included
@@ -79,11 +73,11 @@ BACKLIGHT_MEMORY_FILTER = {"memory": DEV_BL_ADDR, "cmd1": DEV_CMD_MEMORY_WRITE}
 
 async def async_setup_entry(
     hass: HomeAssistant,
-    config_entry: ConfigEntry,
+    config_entry: IsyConfigEntry,
     async_add_entities: AddConfigEntryEntitiesCallback,
 ) -> None:
     """Set up ISY/IoX number entities from config entry."""
-    isy_data: IsyData = hass.data[DOMAIN][config_entry.entry_id]
+    isy_data = config_entry.runtime_data
     device_info = isy_data.devices
     entities: list[
         ISYVariableNumberEntity | ISYAuxControlNumberEntity | ISYBacklightNumberEntity
diff --git a/homeassistant/components/isy994/select.py b/homeassistant/components/isy994/select.py
index 868c96375bb..ce5e224bc88 100644
--- a/homeassistant/components/isy994/select.py
+++ b/homeassistant/components/isy994/select.py
@@ -23,7 +23,6 @@ from pyisy.helpers import EventListener, NodeProperty
 from pyisy.nodes import Node, NodeChangedEvent
 
 from homeassistant.components.select import SelectEntity, SelectEntityDescription
-from homeassistant.config_entries import ConfigEntry
 from homeassistant.const import (
     STATE_UNAVAILABLE,
     STATE_UNKNOWN,
@@ -37,9 +36,9 @@ from homeassistant.helpers.device_registry import DeviceInfo
 from homeassistant.helpers.entity_platform import AddConfigEntryEntitiesCallback
 from homeassistant.helpers.restore_state import RestoreEntity
 
-from .const import _LOGGER, DOMAIN, UOM_INDEX
+from .const import _LOGGER, UOM_INDEX
 from .entity import ISYAuxControlEntity
-from .models import IsyData
+from .models import IsyConfigEntry
 
 
 def time_string(i: int) -> str:
@@ -55,11 +54,11 @@ BACKLIGHT_MEMORY_FILTER = {"memory": DEV_BL_ADDR, "cmd1": DEV_CMD_MEMORY_WRITE}
 
 async def async_setup_entry(
     hass: HomeAssistant,
-    config_entry: ConfigEntry,
+    config_entry: IsyConfigEntry,
     async_add_entities: AddConfigEntryEntitiesCallback,
 ) -> None:
     """Set up ISY/IoX select entities from config entry."""
-    isy_data: IsyData = hass.data[DOMAIN][config_entry.entry_id]
+    isy_data = config_entry.runtime_data
     device_info = isy_data.devices
     entities: list[
         ISYAuxControlIndexSelectEntity
diff --git a/homeassistant/components/isy994/sensor.py b/homeassistant/components/isy994/sensor.py
index 2d27f4602c6..6e0b5a89637 100644
--- a/homeassistant/components/isy994/sensor.py
+++ b/homeassistant/components/isy994/sensor.py
@@ -29,7 +29,6 @@ from homeassistant.components.sensor import (
     SensorEntity,
     SensorStateClass,
 )
-from homeassistant.config_entries import ConfigEntry
 from homeassistant.const import EntityCategory, Platform, UnitOfTemperature
 from homeassistant.core import HomeAssistant, callback
 from homeassistant.helpers.device_registry import DeviceInfo
@@ -37,7 +36,6 @@ from homeassistant.helpers.entity_platform import AddConfigEntryEntitiesCallback
 
 from .const import (
     _LOGGER,
-    DOMAIN,
     UOM_DOUBLE_TEMP,
     UOM_FRIENDLY_NAME,
     UOM_INDEX,
@@ -46,7 +44,7 @@ from .const import (
 )
 from .entity import ISYNodeEntity
 from .helpers import convert_isy_value_to_hass
-from .models import IsyData
+from .models import IsyConfigEntry
 
 # Disable general purpose and redundant sensors by default
 AUX_DISABLED_BY_DEFAULT_MATCH = ["GV", "DO"]
@@ -109,13 +107,13 @@ ISY_CONTROL_TO_ENTITY_CATEGORY = {
 
 async def async_setup_entry(
     hass: HomeAssistant,
-    entry: ConfigEntry,
+    entry: IsyConfigEntry,
     async_add_entities: AddConfigEntryEntitiesCallback,
 ) -> None:
     """Set up the ISY sensor platform."""
-    isy_data: IsyData = hass.data[DOMAIN][entry.entry_id]
+    isy_data = entry.runtime_data
     entities: list[ISYSensorEntity] = []
-    devices: dict[str, DeviceInfo] = isy_data.devices
+    devices = isy_data.devices
 
     for node in isy_data.nodes[Platform.SENSOR]:
         _LOGGER.debug("Loading %s", node.name)
diff --git a/homeassistant/components/isy994/services.py b/homeassistant/components/isy994/services.py
index 24cfa9aefb1..39f72a5cc2c 100644
--- a/homeassistant/components/isy994/services.py
+++ b/homeassistant/components/isy994/services.py
@@ -21,7 +21,7 @@ from homeassistant.helpers.service import entity_service_call
 from homeassistant.helpers.typing import VolDictType
 
 from .const import _LOGGER, DOMAIN
-from .models import IsyData
+from .models import IsyConfigEntry
 
 # Common Services for All Platforms:
 SERVICE_SEND_PROGRAM_COMMAND = "send_program_command"
@@ -149,9 +149,9 @@ def async_setup_services(hass: HomeAssistant) -> None:
         command = service.data[CONF_COMMAND]
         isy_name = service.data.get(CONF_ISY)
 
-        for config_entry_id in hass.data[DOMAIN]:
-            isy_data: IsyData = hass.data[DOMAIN][config_entry_id]
-            isy = isy_data.root
+        config_entry: IsyConfigEntry
+        for config_entry in hass.config_entries.async_loaded_entries(DOMAIN):
+            isy = config_entry.runtime_data.root
             if isy_name and isy_name != isy.conf["name"]:
                 continue
             program = None
@@ -235,10 +235,6 @@ def async_setup_services(hass: HomeAssistant) -> None:
 @callback
 def async_unload_services(hass: HomeAssistant) -> None:
     """Unload services for the ISY integration."""
-    if hass.data[DOMAIN]:
-        # There is still another config entry for this domain, don't remove services.
-        return
-
     existing_services = hass.services.async_services_for_domain(DOMAIN)
     if not existing_services or SERVICE_SEND_PROGRAM_COMMAND not in existing_services:
         return
diff --git a/homeassistant/components/isy994/switch.py b/homeassistant/components/isy994/switch.py
index d5c8a23cbea..f44613317c5 100644
--- a/homeassistant/components/isy994/switch.py
+++ b/homeassistant/components/isy994/switch.py
@@ -20,16 +20,14 @@ from homeassistant.components.switch import (
     SwitchEntity,
     SwitchEntityDescription,
 )
-from homeassistant.config_entries import ConfigEntry
 from homeassistant.const import EntityCategory, Platform
 from homeassistant.core import HomeAssistant, callback
 from homeassistant.exceptions import HomeAssistantError
 from homeassistant.helpers.device_registry import DeviceInfo
 from homeassistant.helpers.entity_platform import AddConfigEntryEntitiesCallback
 
-from .const import DOMAIN
 from .entity import ISYAuxControlEntity, ISYNodeEntity, ISYProgramEntity
-from .models import IsyData
+from .models import IsyConfigEntry
 
 
 @dataclass(frozen=True)
@@ -43,11 +41,11 @@ class ISYSwitchEntityDescription(SwitchEntityDescription):
 
 async def async_setup_entry(
     hass: HomeAssistant,
-    entry: ConfigEntry,
+    entry: IsyConfigEntry,
     async_add_entities: AddConfigEntryEntitiesCallback,
 ) -> None:
     """Set up the ISY switch platform."""
-    isy_data: IsyData = hass.data[DOMAIN][entry.entry_id]
+    isy_data = entry.runtime_data
     entities: list[
         ISYSwitchProgramEntity | ISYSwitchEntity | ISYEnableSwitchEntity
     ] = []
diff --git a/homeassistant/components/isy994/system_health.py b/homeassistant/components/isy994/system_health.py
index dfc45c267dd..9c5a04ba34a 100644
--- a/homeassistant/components/isy994/system_health.py
+++ b/homeassistant/components/isy994/system_health.py
@@ -4,15 +4,12 @@ from __future__ import annotations
 
 from typing import Any
 
-from pyisy import ISY
-
 from homeassistant.components import system_health
-from homeassistant.config_entries import ConfigEntry
 from homeassistant.const import CONF_HOST
 from homeassistant.core import HomeAssistant, callback
 
 from .const import DOMAIN, ISY_URL_POSTFIX
-from .models import IsyData
+from .models import IsyConfigEntry
 
 
 @callback
@@ -27,14 +24,9 @@ async def system_health_info(hass: HomeAssistant) -> dict[str, Any]:
     """Get info for the info page."""
 
     health_info = {}
-    config_entry_id = next(
-        iter(hass.data[DOMAIN])
-    )  # Only first ISY is supported for now
-    isy_data: IsyData = hass.data[DOMAIN][config_entry_id]
-    isy: ISY = isy_data.root
+    entry: IsyConfigEntry = hass.config_entries.async_loaded_entries(DOMAIN)[0]
+    isy = entry.runtime_data.root
 
-    entry = hass.config_entries.async_get_entry(config_entry_id)
-    assert isinstance(entry, ConfigEntry)
     health_info["host_reachable"] = await system_health.async_check_can_reach_url(
         hass, f"{entry.data[CONF_HOST]}{ISY_URL_POSTFIX}"
     )
diff --git a/homeassistant/components/isy994/util.py b/homeassistant/components/isy994/util.py
index ca5c5ea46a9..87cb450d08b 100644
--- a/homeassistant/components/isy994/util.py
+++ b/homeassistant/components/isy994/util.py
@@ -5,16 +5,19 @@ from __future__ import annotations
 from homeassistant.core import HomeAssistant, callback
 from homeassistant.helpers import entity_registry as er
 
-from .const import _LOGGER, DOMAIN
+from .const import _LOGGER
+from .models import IsyConfigEntry
 
 
 @callback
-def _async_cleanup_registry_entries(hass: HomeAssistant, entry_id: str) -> None:
+def _async_cleanup_registry_entries(hass: HomeAssistant, entry: IsyConfigEntry) -> None:
     """Remove extra entities that are no longer part of the integration."""
     entity_registry = er.async_get(hass)
-    isy_data = hass.data[DOMAIN][entry_id]
+    isy_data = entry.runtime_data
 
-    existing_entries = er.async_entries_for_config_entry(entity_registry, entry_id)
+    existing_entries = er.async_entries_for_config_entry(
+        entity_registry, entry.entry_id
+    )
     entities = {
         (entity.domain, entity.unique_id): entity.entity_id
         for entity in existing_entries
@@ -31,5 +34,5 @@ def _async_cleanup_registry_entries(hass: HomeAssistant, entry_id: str) -> None:
     _LOGGER.debug(
         ("Cleaning up ISY entities: removed %s extra entities for config entry %s"),
         len(extra_entities),
-        entry_id,
+        entry.entry_id,
     )
diff --git a/tests/components/isy994/test_system_health.py b/tests/components/isy994/test_system_health.py
index 5f472189513..0a6e4b403b8 100644
--- a/tests/components/isy994/test_system_health.py
+++ b/tests/components/isy994/test_system_health.py
@@ -6,6 +6,7 @@ from unittest.mock import Mock
 from aiohttp import ClientError
 
 from homeassistant.components.isy994.const import DOMAIN, ISY_URL_POSTFIX
+from homeassistant.config_entries import ConfigEntryState
 from homeassistant.const import CONF_HOST
 from homeassistant.core import HomeAssistant
 from homeassistant.setup import async_setup_component
@@ -30,12 +31,14 @@ async def test_system_health(
     assert await async_setup_component(hass, "system_health", {})
     await hass.async_block_till_done()
 
-    MockConfigEntry(
+    entry = MockConfigEntry(
         domain=DOMAIN,
         entry_id=MOCK_ENTRY_ID,
         data={CONF_HOST: f"http://{MOCK_HOSTNAME}"},
         unique_id=MOCK_UUID,
-    ).add_to_hass(hass)
+        state=ConfigEntryState.LOADED,
+    )
+    entry.add_to_hass(hass)
 
     isy_data = Mock(
         root=Mock(
@@ -46,7 +49,7 @@ async def test_system_health(
             ),
         )
     )
-    hass.data[DOMAIN] = {MOCK_ENTRY_ID: isy_data}
+    entry.runtime_data = isy_data
 
     info = await get_system_health_info(hass, DOMAIN)
 
@@ -70,12 +73,14 @@ async def test_system_health_failed_connect(
     assert await async_setup_component(hass, "system_health", {})
     await hass.async_block_till_done()
 
-    MockConfigEntry(
+    entry = MockConfigEntry(
         domain=DOMAIN,
         entry_id=MOCK_ENTRY_ID,
         data={CONF_HOST: f"http://{MOCK_HOSTNAME}"},
         unique_id=MOCK_UUID,
-    ).add_to_hass(hass)
+        state=ConfigEntryState.LOADED,
+    )
+    entry.add_to_hass(hass)
 
     isy_data = Mock(
         root=Mock(
@@ -86,7 +91,7 @@ async def test_system_health_failed_connect(
             ),
         )
     )
-    hass.data[DOMAIN] = {MOCK_ENTRY_ID: isy_data}
+    entry.runtime_data = isy_data
 
     info = await get_system_health_info(hass, DOMAIN)