diff --git a/homeassistant/components/thethingsnetwork/__init__.py b/homeassistant/components/thethingsnetwork/__init__.py
index 253ce7a052e..d3c6c8356cb 100644
--- a/homeassistant/components/thethingsnetwork/__init__.py
+++ b/homeassistant/components/thethingsnetwork/__init__.py
@@ -2,55 +2,15 @@
 
 import logging
 
-import voluptuous as vol
-
 from homeassistant.config_entries import ConfigEntry
 from homeassistant.const import CONF_API_KEY, CONF_HOST
 from homeassistant.core import HomeAssistant
-from homeassistant.helpers import issue_registry as ir
-import homeassistant.helpers.config_validation as cv
-from homeassistant.helpers.typing import ConfigType
 
-from .const import CONF_APP_ID, DOMAIN, PLATFORMS, TTN_API_HOST
+from .const import DOMAIN, PLATFORMS, TTN_API_HOST
 from .coordinator import TTNCoordinator
 
 _LOGGER = logging.getLogger(__name__)
 
-CONFIG_SCHEMA = vol.Schema(
-    {
-        # Configuration via yaml not longer supported - keeping to warn about migration
-        DOMAIN: vol.Schema(
-            {
-                vol.Required(CONF_APP_ID): cv.string,
-                vol.Required("access_key"): cv.string,
-            }
-        )
-    },
-    extra=vol.ALLOW_EXTRA,
-)
-
-
-async def async_setup(hass: HomeAssistant, config: ConfigType) -> bool:
-    """Initialize of The Things Network component."""
-
-    if DOMAIN in config:
-        ir.async_create_issue(
-            hass,
-            DOMAIN,
-            "manual_migration",
-            breaks_in_ha_version="2024.12.0",
-            is_fixable=False,
-            severity=ir.IssueSeverity.ERROR,
-            translation_key="manual_migration",
-            translation_placeholders={
-                "domain": DOMAIN,
-                "v2_v3_migration_url": "https://www.thethingsnetwork.org/forum/c/v2-to-v3-upgrade/102",
-                "v2_deprecation_url": "https://www.thethingsnetwork.org/forum/t/the-things-network-v2-is-permanently-shutting-down-completed/50710",
-            },
-        )
-
-    return True
-
 
 async def async_setup_entry(hass: HomeAssistant, entry: ConfigEntry) -> bool:
     """Establish connection with The Things Network."""
diff --git a/homeassistant/components/thethingsnetwork/strings.json b/homeassistant/components/thethingsnetwork/strings.json
index 98572cb318c..f5a4fcef8fd 100644
--- a/homeassistant/components/thethingsnetwork/strings.json
+++ b/homeassistant/components/thethingsnetwork/strings.json
@@ -22,11 +22,5 @@
       "invalid_auth": "[%key:common::config_flow::error::invalid_auth%]",
       "unknown": "[%key:common::config_flow::error::unknown%]"
     }
-  },
-  "issues": {
-    "manual_migration": {
-      "description": "Configuring {domain} using YAML was removed as part of migrating to [The Things Network v3]({v2_v3_migration_url}). [The Things Network v2 has shutted down]({v2_deprecation_url}).\n\nPlease remove the {domain} entry from the configuration.yaml and add re-add the integration using the config_flow",
-      "title": "The {domain} YAML configuration is not supported"
-    }
   }
 }
diff --git a/tests/components/thethingsnetwork/test_init.py b/tests/components/thethingsnetwork/test_init.py
index 1e0b64c933d..e39c764d5f9 100644
--- a/tests/components/thethingsnetwork/test_init.py
+++ b/tests/components/thethingsnetwork/test_init.py
@@ -4,22 +4,6 @@ import pytest
 from ttn_client import TTNAuthError
 
 from homeassistant.core import HomeAssistant
-from homeassistant.helpers import issue_registry as ir
-from homeassistant.setup import async_setup_component
-
-from .conftest import DOMAIN
-
-
-async def test_error_configuration(
-    hass: HomeAssistant,
-    issue_registry: ir.IssueRegistry,
-) -> None:
-    """Test issue is logged when deprecated configuration is used."""
-    await async_setup_component(
-        hass, DOMAIN, {DOMAIN: {"app_id": "123", "access_key": "42"}}
-    )
-    await hass.async_block_till_done()
-    assert issue_registry.async_get_issue(DOMAIN, "manual_migration")
 
 
 @pytest.mark.parametrize(("exception_class"), [TTNAuthError, Exception])