diff --git a/homeassistant/components/mqtt/client.py b/homeassistant/components/mqtt/client.py
index 2ebd105b432..40e5532c71a 100644
--- a/homeassistant/components/mqtt/client.py
+++ b/homeassistant/components/mqtt/client.py
@@ -309,10 +309,11 @@ class MqttClientSetup:
         if (client_id := config.get(CONF_CLIENT_ID)) is None:
             # PAHO MQTT relies on the MQTT server to generate random client IDs.
             # However, that feature is not mandatory so we generate our own.
-            client_id = mqtt.base62(uuid.uuid4().int, padding=22)
+            client_id = mqtt._base62(uuid.uuid4().int, padding=22)  # type: ignore[attr-defined]
         transport: str = config.get(CONF_TRANSPORT, DEFAULT_TRANSPORT)
         self._client = AsyncMQTTClient(
-            client_id,
+            callback_api_version=mqtt.CallbackAPIVersion.VERSION2,
+            client_id=client_id,
             protocol=proto,
             transport=transport,
             reconnect_on_failure=False,
@@ -1132,13 +1133,10 @@ class MQTT:
         _mqttc: mqtt.Client,
         _userdata: None,
         mid: int,
-        _granted_qos_reason: tuple[int, ...] | mqtt.ReasonCodes | None = None,
-        _properties_reason: mqtt.ReasonCodes | None = None,
+        _reason: mqtt.ReasonCodes | None = None,
+        _properties: mqtt.Properties | None = None,
     ) -> None:
         """Publish / Subscribe / Unsubscribe callback."""
-        # The callback signature for on_unsubscribe is different from on_subscribe
-        # see https://github.com/eclipse/paho.mqtt.python/issues/687
-        # properties and reason codes are not used in Home Assistant
         future = self._async_get_mid_future(mid)
         if future.done() and (future.cancelled() or future.exception()):
             # Timed out or cancelled
diff --git a/homeassistant/components/mqtt/manifest.json b/homeassistant/components/mqtt/manifest.json
index 34370c82507..7e09af6d398 100644
--- a/homeassistant/components/mqtt/manifest.json
+++ b/homeassistant/components/mqtt/manifest.json
@@ -7,5 +7,5 @@
   "documentation": "https://www.home-assistant.io/integrations/mqtt",
   "iot_class": "local_push",
   "quality_scale": "platinum",
-  "requirements": ["paho-mqtt==1.6.1"]
+  "requirements": ["paho-mqtt==2.1.0"]
 }
diff --git a/homeassistant/package_constraints.txt b/homeassistant/package_constraints.txt
index 2509737d87a..3bae780f68b 100644
--- a/homeassistant/package_constraints.txt
+++ b/homeassistant/package_constraints.txt
@@ -41,7 +41,7 @@ lru-dict==1.3.0
 mutagen==1.47.0
 orjson==3.10.6
 packaging>=23.1
-paho-mqtt==1.6.1
+paho-mqtt==2.1.0
 Pillow==10.3.0
 pip>=21.3.1
 psutil-home-assistant==0.0.1
diff --git a/requirements_all.txt b/requirements_all.txt
index 00b421526c0..e29879beb06 100644
--- a/requirements_all.txt
+++ b/requirements_all.txt
@@ -1523,7 +1523,7 @@ ovoenergy==2.0.0
 p1monitor==3.0.1
 
 # homeassistant.components.mqtt
-paho-mqtt==1.6.1
+paho-mqtt==2.1.0
 
 # homeassistant.components.panasonic_bluray
 panacotta==0.2
diff --git a/requirements_test_all.txt b/requirements_test_all.txt
index 9595d2c0c08..63184d834af 100644
--- a/requirements_test_all.txt
+++ b/requirements_test_all.txt
@@ -1238,7 +1238,7 @@ ovoenergy==2.0.0
 p1monitor==3.0.1
 
 # homeassistant.components.mqtt
-paho-mqtt==1.6.1
+paho-mqtt==2.1.0
 
 # homeassistant.components.panasonic_viera
 panasonic-viera==0.4.2