diff --git a/homeassistant/components/plugwise/gateway.py b/homeassistant/components/plugwise/gateway.py
index f540c6d0b9c..648765155e4 100644
--- a/homeassistant/components/plugwise/gateway.py
+++ b/homeassistant/components/plugwise/gateway.py
@@ -4,6 +4,7 @@ from __future__ import annotations
 import asyncio
 from typing import Any
 
+from aiohttp import ClientConnectionError
 from plugwise.exceptions import InvalidAuthentication, PlugwiseException
 from plugwise.smile import Smile
 
@@ -44,7 +45,7 @@ async def async_setup_entry_gw(hass: HomeAssistant, entry: ConfigEntry) -> bool:
     except InvalidAuthentication:
         LOGGER.error("Invalid username or Smile ID")
         return False
-    except PlugwiseException as err:
+    except (ClientConnectionError, PlugwiseException) as err:
         raise ConfigEntryNotReady(
             f"Error while communicating to device {api.smile_name}"
         ) from err
diff --git a/tests/components/plugwise/test_init.py b/tests/components/plugwise/test_init.py
index 811018db7e2..557680cb060 100644
--- a/tests/components/plugwise/test_init.py
+++ b/tests/components/plugwise/test_init.py
@@ -2,6 +2,7 @@
 import asyncio
 from unittest.mock import MagicMock
 
+import aiohttp
 from plugwise.exceptions import (
     ConnectionFailedError,
     PlugwiseException,
@@ -49,6 +50,7 @@ async def test_load_unload_config_entry(
         (PlugwiseException),
         (XMLDataMissingError),
         (asyncio.TimeoutError),
+        (aiohttp.ClientConnectionError),
     ],
 )
 async def test_config_entry_not_ready(