diff --git a/homeassistant/package_constraints.txt b/homeassistant/package_constraints.txt
index c1acde9fcbd..cf68cda8531 100644
--- a/homeassistant/package_constraints.txt
+++ b/homeassistant/package_constraints.txt
@@ -50,7 +50,7 @@ httplib2>=0.19.0
 # gRPC is an implicit dependency that we want to make explicit so we manage
 # upgrades intentionally. It is a large package to build from source and we
 # want to ensure we have wheels built.
-grpcio==1.44.0
+grpcio==1.45.0
 
 # libcst >=0.4.0 requires a newer Rust than we currently have available,
 # thus our wheels builds fail. This pins it to the last working version,
diff --git a/script/gen_requirements_all.py b/script/gen_requirements_all.py
index 896c87a2d80..c48a59f90d3 100755
--- a/script/gen_requirements_all.py
+++ b/script/gen_requirements_all.py
@@ -67,7 +67,7 @@ httplib2>=0.19.0
 # gRPC is an implicit dependency that we want to make explicit so we manage
 # upgrades intentionally. It is a large package to build from source and we
 # want to ensure we have wheels built.
-grpcio==1.44.0
+grpcio==1.45.0
 
 # libcst >=0.4.0 requires a newer Rust than we currently have available,
 # thus our wheels builds fail. This pins it to the last working version,