diff --git a/Dockerfile b/Dockerfile
index 44edbdf8e3e..2d95cf68d16 100644
--- a/Dockerfile
+++ b/Dockerfile
@@ -12,7 +12,7 @@ ENV \
 ARG QEMU_CPU
 
 # Install uv
-RUN pip3 install uv==0.4.17
+RUN pip3 install uv==0.4.22
 
 WORKDIR /usr/src
 
diff --git a/homeassistant/package_constraints.txt b/homeassistant/package_constraints.txt
index 34affc80e1e..3074604d32e 100644
--- a/homeassistant/package_constraints.txt
+++ b/homeassistant/package_constraints.txt
@@ -60,7 +60,7 @@ SQLAlchemy==2.0.31
 typing-extensions>=4.12.2,<5.0
 ulid-transform==1.0.2
 urllib3>=1.26.5,<2
-uv==0.4.17
+uv==0.4.22
 voluptuous-openapi==0.0.5
 voluptuous-serialize==2.6.0
 voluptuous==0.15.2
diff --git a/pyproject.toml b/pyproject.toml
index d79a0b03537..0f561eb4a48 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -69,7 +69,7 @@ dependencies    = [
     # Temporary setting an upper bound, to prevent compat issues with urllib3>=2
     # https://github.com/home-assistant/core/issues/97248
     "urllib3>=1.26.5,<2",
-    "uv==0.4.17",
+    "uv==0.4.22",
     "voluptuous==0.15.2",
     "voluptuous-serialize==2.6.0",
     "voluptuous-openapi==0.0.5",
diff --git a/requirements.txt b/requirements.txt
index 6075550a6c6..8811084601a 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -39,7 +39,7 @@ SQLAlchemy==2.0.31
 typing-extensions>=4.12.2,<5.0
 ulid-transform==1.0.2
 urllib3>=1.26.5,<2
-uv==0.4.17
+uv==0.4.22
 voluptuous==0.15.2
 voluptuous-serialize==2.6.0
 voluptuous-openapi==0.0.5
diff --git a/script/hassfest/docker/Dockerfile b/script/hassfest/docker/Dockerfile
index f1194e37e2f..5fe8b1ab8d2 100644
--- a/script/hassfest/docker/Dockerfile
+++ b/script/hassfest/docker/Dockerfile
@@ -14,7 +14,7 @@ WORKDIR "/github/workspace"
 COPY . /usr/src/homeassistant
 
 # Uv is only needed during build
-RUN --mount=from=ghcr.io/astral-sh/uv:0.4.17,source=/uv,target=/bin/uv \
+RUN --mount=from=ghcr.io/astral-sh/uv:0.4.22,source=/uv,target=/bin/uv \
     # Required for PyTurboJPEG
     apk add --no-cache libturbojpeg \
     && uv pip install \