diff --git a/CODEOWNERS b/CODEOWNERS
index 832c571ae4..b3c66c775b 100644
--- a/CODEOWNERS
+++ b/CODEOWNERS
@@ -332,6 +332,7 @@ esphome/components/pca6416a/* @Mat931
 esphome/components/pca9554/* @clydebarrow @hwstar
 esphome/components/pcf85063/* @brogon
 esphome/components/pcf8563/* @KoenBreeman
+esphome/components/pi4ioe5v6408/* @jesserockz
 esphome/components/pid/* @OttoWinter
 esphome/components/pipsolar/* @andreashergert1984
 esphome/components/pm1006/* @habbie
diff --git a/esphome/components/pi4ioe5v6408/__init__.py b/esphome/components/pi4ioe5v6408/__init__.py
new file mode 100644
index 0000000000..c64f923823
--- /dev/null
+++ b/esphome/components/pi4ioe5v6408/__init__.py
@@ -0,0 +1,84 @@
+from esphome import pins
+import esphome.codegen as cg
+from esphome.components import i2c
+import esphome.config_validation as cv
+from esphome.const import (
+    CONF_ID,
+    CONF_INPUT,
+    CONF_INVERTED,
+    CONF_MODE,
+    CONF_NUMBER,
+    CONF_OUTPUT,
+    CONF_PULLDOWN,
+    CONF_PULLUP,
+    CONF_RESET,
+)
+
+AUTO_LOAD = ["gpio_expander"]
+CODEOWNERS = ["@jesserockz"]
+DEPENDENCIES = ["i2c"]
+MULTI_CONF = True
+
+
+pi4ioe5v6408_ns = cg.esphome_ns.namespace("pi4ioe5v6408")
+PI4IOE5V6408Component = pi4ioe5v6408_ns.class_(
+    "PI4IOE5V6408Component", cg.Component, i2c.I2CDevice
+)
+PI4IOE5V6408GPIOPin = pi4ioe5v6408_ns.class_("PI4IOE5V6408GPIOPin", cg.GPIOPin)
+
+CONF_PI4IOE5V6408 = "pi4ioe5v6408"
+
+CONFIG_SCHEMA = (
+    cv.Schema(
+        {
+            cv.Required(CONF_ID): cv.declare_id(PI4IOE5V6408Component),
+            cv.Optional(CONF_RESET, default=True): cv.boolean,
+        }
+    )
+    .extend(cv.COMPONENT_SCHEMA)
+    .extend(i2c.i2c_device_schema(0x43))
+)
+
+
+async def to_code(config):
+    var = cg.new_Pvariable(config[CONF_ID])
+    await cg.register_component(var, config)
+    await i2c.register_i2c_device(var, config)
+
+    cg.add(var.set_reset(config[CONF_RESET]))
+
+
+def validate_mode(value):
+    if not (value[CONF_INPUT] or value[CONF_OUTPUT]):
+        raise cv.Invalid("Mode must be either input or output")
+    if value[CONF_INPUT] and value[CONF_OUTPUT]:
+        raise cv.Invalid("Mode must be either input or output")
+    return value
+
+
+PI4IOE5V6408_PIN_SCHEMA = pins.gpio_base_schema(
+    PI4IOE5V6408GPIOPin,
+    cv.int_range(min=0, max=7),
+    modes=[
+        CONF_INPUT,
+        CONF_OUTPUT,
+        CONF_PULLUP,
+        CONF_PULLDOWN,
+    ],
+    mode_validator=validate_mode,
+).extend(
+    {
+        cv.Required(CONF_PI4IOE5V6408): cv.use_id(PI4IOE5V6408Component),
+    }
+)
+
+
+@pins.PIN_SCHEMA_REGISTRY.register(CONF_PI4IOE5V6408, PI4IOE5V6408_PIN_SCHEMA)
+async def pi4ioe5v6408_pin_schema(config):
+    var = cg.new_Pvariable(config[CONF_ID])
+    await cg.register_parented(var, config[CONF_PI4IOE5V6408])
+
+    cg.add(var.set_pin(config[CONF_NUMBER]))
+    cg.add(var.set_inverted(config[CONF_INVERTED]))
+    cg.add(var.set_flags(pins.gpio_flags_expr(config[CONF_MODE])))
+    return var
diff --git a/esphome/components/pi4ioe5v6408/pi4ioe5v6408.cpp b/esphome/components/pi4ioe5v6408/pi4ioe5v6408.cpp
new file mode 100644
index 0000000000..55b8edffc8
--- /dev/null
+++ b/esphome/components/pi4ioe5v6408/pi4ioe5v6408.cpp
@@ -0,0 +1,171 @@
+#include "pi4ioe5v6408.h"
+#include "esphome/core/log.h"
+
+namespace esphome {
+namespace pi4ioe5v6408 {
+
+static const uint8_t PI4IOE5V6408_REGISTER_DEVICE_ID = 0x01;
+static const uint8_t PI4IOE5V6408_REGISTER_IO_DIR = 0x03;
+static const uint8_t PI4IOE5V6408_REGISTER_OUT_SET = 0x05;
+static const uint8_t PI4IOE5V6408_REGISTER_OUT_HIGH_IMPEDENCE = 0x07;
+static const uint8_t PI4IOE5V6408_REGISTER_IN_DEFAULT_STATE = 0x09;
+static const uint8_t PI4IOE5V6408_REGISTER_PULL_ENABLE = 0x0B;
+static const uint8_t PI4IOE5V6408_REGISTER_PULL_SELECT = 0x0D;
+static const uint8_t PI4IOE5V6408_REGISTER_IN_STATE = 0x0F;
+static const uint8_t PI4IOE5V6408_REGISTER_INTERRUPT_ENABLE_MASK = 0x11;
+static const uint8_t PI4IOE5V6408_REGISTER_INTERRUPT_STATUS = 0x13;
+
+static const char *const TAG = "pi4ioe5v6408";
+
+void PI4IOE5V6408Component::setup() {
+  ESP_LOGCONFIG(TAG, "Running setup");
+  if (this->reset_) {
+    this->reg(PI4IOE5V6408_REGISTER_DEVICE_ID) |= 0b00000001;
+    this->reg(PI4IOE5V6408_REGISTER_OUT_HIGH_IMPEDENCE) = 0b00000000;
+  } else {
+    if (!this->read_gpio_modes_()) {
+      this->mark_failed();
+      ESP_LOGE(TAG, "Failed to read GPIO modes");
+      return;
+    }
+    if (!this->read_gpio_outputs_()) {
+      this->mark_failed();
+      ESP_LOGE(TAG, "Failed to read GPIO outputs");
+      return;
+    }
+  }
+}
+void PI4IOE5V6408Component::dump_config() {
+  ESP_LOGCONFIG(TAG, "PI4IOE5V6408:");
+  LOG_I2C_DEVICE(this)
+  if (this->is_failed()) {
+    ESP_LOGE(TAG, ESP_LOG_MSG_COMM_FAIL);
+  }
+}
+void PI4IOE5V6408Component::pin_mode(uint8_t pin, gpio::Flags flags) {
+  if (flags & gpio::FLAG_OUTPUT) {
+    // Set mode mask bit
+    this->mode_mask_ |= 1 << pin;
+  } else if (flags & gpio::FLAG_INPUT) {
+    // Clear mode mask bit
+    this->mode_mask_ &= ~(1 << pin);
+    if (flags & gpio::FLAG_PULLUP) {
+      this->pull_up_down_mask_ |= 1 << pin;
+      this->pull_enable_mask_ |= 1 << pin;
+    } else if (flags & gpio::FLAG_PULLDOWN) {
+      this->pull_up_down_mask_ &= ~(1 << pin);
+      this->pull_enable_mask_ |= 1 << pin;
+    }
+  }
+  // Write GPIO to enable input mode
+  this->write_gpio_modes_();
+}
+
+void PI4IOE5V6408Component::loop() { this->reset_pin_cache_(); }
+
+bool PI4IOE5V6408Component::read_gpio_outputs_() {
+  if (this->is_failed())
+    return false;
+
+  uint8_t data;
+  if (!this->read_byte(PI4IOE5V6408_REGISTER_OUT_SET, &data)) {
+    this->status_set_warning("Failed to read output register");
+    return false;
+  }
+  this->output_mask_ = data;
+  this->status_clear_warning();
+  return true;
+}
+
+bool PI4IOE5V6408Component::read_gpio_modes_() {
+  if (this->is_failed())
+    return false;
+
+  uint8_t data;
+  if (!this->read_byte(PI4IOE5V6408_REGISTER_IO_DIR, &data)) {
+    this->status_set_warning("Failed to read GPIO modes");
+    return false;
+  }
+#if ESPHOME_LOG_LEVEL >= ESPHOME_LOG_LEVEL_VERBOSE
+  ESP_LOGV(TAG, "Read GPIO modes: 0b" BYTE_TO_BINARY_PATTERN, BYTE_TO_BINARY(data));
+#endif
+  this->mode_mask_ = data;
+  this->status_clear_warning();
+  return true;
+}
+
+bool PI4IOE5V6408Component::digital_read_hw(uint8_t pin) {
+  if (this->is_failed())
+    return false;
+
+  uint8_t data;
+  if (!this->read_byte(PI4IOE5V6408_REGISTER_IN_STATE, &data)) {
+    this->status_set_warning("Failed to read GPIO state");
+    return false;
+  }
+  this->input_mask_ = data;
+  this->status_clear_warning();
+  return true;
+}
+
+void PI4IOE5V6408Component::digital_write_hw(uint8_t pin, bool value) {
+  if (this->is_failed())
+    return;
+
+  if (value) {
+    this->output_mask_ |= (1 << pin);
+  } else {
+    this->output_mask_ &= ~(1 << pin);
+  }
+  if (!this->write_byte(PI4IOE5V6408_REGISTER_OUT_SET, this->output_mask_)) {
+    this->status_set_warning("Failed to write output register");
+    return;
+  }
+#if ESPHOME_LOG_LEVEL >= ESPHOME_LOG_LEVEL_VERBOSE
+  ESP_LOGV(TAG, "Wrote GPIO output: 0b" BYTE_TO_BINARY_PATTERN, BYTE_TO_BINARY(this->output_mask_));
+#endif
+  this->status_clear_warning();
+}
+
+bool PI4IOE5V6408Component::write_gpio_modes_() {
+  if (this->is_failed())
+    return false;
+
+  if (!this->write_byte(PI4IOE5V6408_REGISTER_IO_DIR, this->mode_mask_)) {
+    this->status_set_warning("Failed to write GPIO modes");
+    return false;
+  }
+  if (!this->write_byte(PI4IOE5V6408_REGISTER_PULL_SELECT, this->pull_up_down_mask_)) {
+    this->status_set_warning("Failed to write GPIO pullup/pulldown");
+    return false;
+  }
+  if (!this->write_byte(PI4IOE5V6408_REGISTER_PULL_ENABLE, this->pull_enable_mask_)) {
+    this->status_set_warning("Failed to write GPIO pull enable");
+    return false;
+  }
+#if ESPHOME_LOG_LEVEL >= ESPHOME_LOG_LEVEL_VERBOSE
+  ESP_LOGV(TAG,
+           "Wrote GPIO modes: 0b" BYTE_TO_BINARY_PATTERN "\n"
+           "Wrote GPIO pullup/pulldown: 0b" BYTE_TO_BINARY_PATTERN "\n"
+           "Wrote GPIO pull enable: 0b" BYTE_TO_BINARY_PATTERN,
+           BYTE_TO_BINARY(this->mode_mask_), BYTE_TO_BINARY(this->pull_up_down_mask_),
+           BYTE_TO_BINARY(this->pull_enable_mask_));
+#endif
+  this->status_clear_warning();
+  return true;
+}
+
+bool PI4IOE5V6408Component::digital_read_cache(uint8_t pin) { return (this->input_mask_ & (1 << pin)); }
+
+float PI4IOE5V6408Component::get_setup_priority() const { return setup_priority::IO; }
+
+void PI4IOE5V6408GPIOPin::setup() { this->pin_mode(this->flags_); }
+void PI4IOE5V6408GPIOPin::pin_mode(gpio::Flags flags) { this->parent_->pin_mode(this->pin_, flags); }
+bool PI4IOE5V6408GPIOPin::digital_read() { return this->parent_->digital_read(this->pin_) != this->inverted_; }
+void PI4IOE5V6408GPIOPin::digital_write(bool value) {
+  this->parent_->digital_write(this->pin_, value != this->inverted_);
+}
+std::string PI4IOE5V6408GPIOPin::dump_summary() const { return str_sprintf("%u via PI4IOE5V6408", this->pin_); }
+
+}  // namespace pi4ioe5v6408
+}  // namespace esphome
diff --git a/esphome/components/pi4ioe5v6408/pi4ioe5v6408.h b/esphome/components/pi4ioe5v6408/pi4ioe5v6408.h
new file mode 100644
index 0000000000..82b3076fab
--- /dev/null
+++ b/esphome/components/pi4ioe5v6408/pi4ioe5v6408.h
@@ -0,0 +1,70 @@
+#pragma once
+
+#include "esphome/components/gpio_expander/cached_gpio.h"
+#include "esphome/components/i2c/i2c.h"
+#include "esphome/core/component.h"
+#include "esphome/core/hal.h"
+
+namespace esphome {
+namespace pi4ioe5v6408 {
+class PI4IOE5V6408Component : public Component,
+                              public i2c::I2CDevice,
+                              public gpio_expander::CachedGpioExpander<uint8_t, 8> {
+ public:
+  PI4IOE5V6408Component() = default;
+
+  void setup() override;
+  void pin_mode(uint8_t pin, gpio::Flags flags);
+
+  float get_setup_priority() const override;
+  void dump_config() override;
+  void loop() override;
+
+  /// Indicate if the component should reset the state during setup
+  void set_reset(bool reset) { this->reset_ = reset; }
+
+ protected:
+  bool digital_read_hw(uint8_t pin) override;
+  bool digital_read_cache(uint8_t pin) override;
+  void digital_write_hw(uint8_t pin, bool value) override;
+
+  /// Mask for the pin mode - 1 means output, 0 means input
+  uint8_t mode_mask_{0x00};
+  /// The mask to write as output state - 1 means HIGH, 0 means LOW
+  uint8_t output_mask_{0x00};
+  /// The state read in digital_read_hw - 1 means HIGH, 0 means LOW
+  uint8_t input_mask_{0x00};
+  /// The mask to write as input buffer state - 1 means enabled, 0 means disabled
+  uint8_t pull_enable_mask_{0x00};
+  /// The mask to write as pullup state - 1 means pullup, 0 means pulldown
+  uint8_t pull_up_down_mask_{0x00};
+
+  bool reset_{true};
+
+  bool read_gpio_modes_();
+  bool write_gpio_modes_();
+  bool read_gpio_outputs_();
+};
+
+class PI4IOE5V6408GPIOPin : public GPIOPin, public Parented<PI4IOE5V6408Component> {
+ public:
+  void setup() override;
+  void pin_mode(gpio::Flags flags) override;
+  bool digital_read() override;
+  void digital_write(bool value) override;
+  std::string dump_summary() const override;
+
+  void set_pin(uint8_t pin) { this->pin_ = pin; }
+  void set_inverted(bool inverted) { this->inverted_ = inverted; }
+  void set_flags(gpio::Flags flags) { this->flags_ = flags; }
+
+  gpio::Flags get_flags() const override { return this->flags_; }
+
+ protected:
+  uint8_t pin_;
+  bool inverted_;
+  gpio::Flags flags_;
+};
+
+}  // namespace pi4ioe5v6408
+}  // namespace esphome
diff --git a/tests/components/pi4ioe5v6408/common.yaml b/tests/components/pi4ioe5v6408/common.yaml
new file mode 100644
index 0000000000..4130dc2652
--- /dev/null
+++ b/tests/components/pi4ioe5v6408/common.yaml
@@ -0,0 +1,22 @@
+i2c:
+  id: i2c_pi4ioe5v6408
+  sda: ${i2c_sda}
+  scl: ${i2c_scl}
+
+pi4ioe5v6408:
+  id: pi4ioe1
+  address: 0x44
+
+switch:
+  - platform: gpio
+    id: switch1
+    pin:
+      pi4ioe5v6408: pi4ioe1
+      number: 0
+
+binary_sensor:
+  - platform: gpio
+    id: sensor1
+    pin:
+      pi4ioe5v6408: pi4ioe1
+      number: 1
diff --git a/tests/components/pi4ioe5v6408/test.esp32-ard.yaml b/tests/components/pi4ioe5v6408/test.esp32-ard.yaml
new file mode 100644
index 0000000000..55e6edfbf3
--- /dev/null
+++ b/tests/components/pi4ioe5v6408/test.esp32-ard.yaml
@@ -0,0 +1,5 @@
+substitutions:
+  i2c_sda: GPIO21
+  i2c_scl: GPIO22
+
+<<: !include common.yaml
diff --git a/tests/components/pi4ioe5v6408/test.esp32-idf.yaml b/tests/components/pi4ioe5v6408/test.esp32-idf.yaml
new file mode 100644
index 0000000000..55e6edfbf3
--- /dev/null
+++ b/tests/components/pi4ioe5v6408/test.esp32-idf.yaml
@@ -0,0 +1,5 @@
+substitutions:
+  i2c_sda: GPIO21
+  i2c_scl: GPIO22
+
+<<: !include common.yaml
diff --git a/tests/components/pi4ioe5v6408/test.rp2040-ard.yaml b/tests/components/pi4ioe5v6408/test.rp2040-ard.yaml
new file mode 100644
index 0000000000..b7b6b13bfe
--- /dev/null
+++ b/tests/components/pi4ioe5v6408/test.rp2040-ard.yaml
@@ -0,0 +1,5 @@
+substitutions:
+  i2c_sda: GPIO4
+  i2c_scl: GPIO5
+
+<<: !include common.yaml