diff --git a/tests/integration/conftest.py b/tests/integration/conftest.py
index 8f5f77ca52..aead6a73af 100644
--- a/tests/integration/conftest.py
+++ b/tests/integration/conftest.py
@@ -165,6 +165,19 @@ async def compile_esphome(
     """Compile an ESPHome configuration and return the binary path."""
 
     async def _compile(config_path: Path) -> Path:
+        # Create a unique PlatformIO directory for this test to avoid race conditions
+        platformio_dir = integration_test_dir / ".platformio"
+        platformio_dir.mkdir(parents=True, exist_ok=True)
+
+        # Create cache directory as well
+        platformio_cache_dir = platformio_dir / ".cache"
+        platformio_cache_dir.mkdir(parents=True, exist_ok=True)
+
+        # Set up environment with isolated PlatformIO directories
+        env = os.environ.copy()
+        env["PLATFORMIO_CORE_DIR"] = str(platformio_dir)
+        env["PLATFORMIO_CACHE_DIR"] = str(platformio_cache_dir)
+
         # Retry compilation up to 3 times if we get a segfault
         max_retries = 3
         for attempt in range(max_retries):
@@ -179,6 +192,7 @@ async def compile_esphome(
                 stdin=asyncio.subprocess.DEVNULL,
                 # Start in a new process group to isolate signal handling
                 start_new_session=True,
+                env=env,
             )
             await proc.wait()