diff --git a/script/setup b/script/setup
index 0faa746f3a..acc2ec58b4 100755
--- a/script/setup
+++ b/script/setup
@@ -4,25 +4,28 @@
 set -e
 
 cd "$(dirname "$0")/.."
-location="venv/bin/activate"
 if [ ! -n "$DEVCONTAINER" ] && [ ! -n "$VIRTUAL_ENV" ] && [ ! "$ESPHOME_NO_VENV" ]; then
-  python3 -m venv venv
-  if [ -f venv/Scripts/activate ]; then
-    location="venv/Scripts/activate"
+  if [ -x "$(command -v uv)" ]; then
+    uv venv venv
+  else
+    python3 -m venv venv
   fi
-  source $location
+  source venv/bin/activate
 fi
 
-pip3 install -r requirements.txt -r requirements_test.txt -r requirements_dev.txt
-pip3 install setuptools wheel
-pip3 install -e ".[dev,test]" --config-settings editable_mode=compat
+if ! [ -x "$(command -v uv)" ]; then
+  python3 -m pip install uv
+fi
+
+uv pip install setuptools wheel
+uv pip install -e ".[dev,test]" --config-settings editable_mode=compat
 
 pre-commit install
 
 script/platformio_install_deps.py platformio.ini --libraries --tools --platforms
 
-mkdir .temp
+mkdir -p .temp
 
 echo
 echo
-echo "Virtual environment created. Run 'source $location' to use it."
+echo "Virtual environment created. Run 'source venv/bin/activate' to use it."