diff --git a/src/components/device/ha-device-picker.ts b/src/components/device/ha-device-picker.ts
index d93e717b27..c51032eee9 100644
--- a/src/components/device/ha-device-picker.ts
+++ b/src/components/device/ha-device-picker.ts
@@ -84,6 +84,14 @@ export class HaDevicePicker extends SubscribeMixin(LitElement) {
   @property({ type: Array, attribute: "include-device-classes" })
   public includeDeviceClasses?: string[];
 
+  /**
+   * List of devices to be excluded.
+   * @type {Array}
+   * @attr exclude-devices
+   */
+  @property({ type: Array, attribute: "exclude-devices" })
+  public excludeDevices?: string[];
+
   @property() public deviceFilter?: HaDevicePickerDeviceFilterFunc;
 
   @property({ type: Boolean }) public disabled?: boolean;
@@ -104,7 +112,8 @@ export class HaDevicePicker extends SubscribeMixin(LitElement) {
       includeDomains: this["includeDomains"],
       excludeDomains: this["excludeDomains"],
       includeDeviceClasses: this["includeDeviceClasses"],
-      deviceFilter: this["deviceFilter"]
+      deviceFilter: this["deviceFilter"],
+      excludeDevices: this["excludeDevices"]
     ): Device[] => {
       if (!devices.length) {
         return [
@@ -164,6 +173,12 @@ export class HaDevicePicker extends SubscribeMixin(LitElement) {
         });
       }
 
+      if (excludeDevices) {
+        inputDevices = inputDevices.filter(
+          (device) => !excludeDevices!.includes(device.id)
+        );
+      }
+
       if (includeDeviceClasses) {
         inputDevices = inputDevices.filter((device) => {
           const devEntities = deviceEntityLookup[device.id];
@@ -258,7 +273,8 @@ export class HaDevicePicker extends SubscribeMixin(LitElement) {
         this.includeDomains,
         this.excludeDomains,
         this.includeDeviceClasses,
-        this.deviceFilter
+        this.deviceFilter,
+        this.excludeDevices
       );
     }
   }
diff --git a/src/components/ha-area-picker.ts b/src/components/ha-area-picker.ts
index ec242ba8cc..d45f4fdb89 100644
--- a/src/components/ha-area-picker.ts
+++ b/src/components/ha-area-picker.ts
@@ -73,6 +73,14 @@ export class HaAreaPicker extends LitElement {
   @property({ type: Array, attribute: "include-device-classes" })
   public includeDeviceClasses?: string[];
 
+  /**
+   * List of areas to be excluded.
+   * @type {Array}
+   * @attr exclude-areas
+   */
+  @property({ type: Array, attribute: "exclude-areas" })
+  public excludeAreas?: string[];
+
   @property() public deviceFilter?: HaDevicePickerDeviceFilterFunc;
 
   @property() public entityFilter?: (entity: EntityRegistryEntry) => boolean;
@@ -109,7 +117,8 @@ export class HaAreaPicker extends LitElement {
       includeDeviceClasses: this["includeDeviceClasses"],
       deviceFilter: this["deviceFilter"],
       entityFilter: this["entityFilter"],
-      noAdd: this["noAdd"]
+      noAdd: this["noAdd"],
+      excludeAreas: this["excludeAreas"]
     ): AreaRegistryEntry[] => {
       if (!areas.length) {
         return [
@@ -235,6 +244,12 @@ export class HaAreaPicker extends LitElement {
         outputAreas = areas.filter((area) => areaIds!.includes(area.area_id));
       }
 
+      if (excludeAreas) {
+        outputAreas = outputAreas.filter(
+          (area) => !excludeAreas!.includes(area.area_id)
+        );
+      }
+
       if (!outputAreas.length) {
         outputAreas = [
           {
@@ -264,7 +279,7 @@ export class HaAreaPicker extends LitElement {
       (this._init && changedProps.has("_opened") && this._opened)
     ) {
       this._init = true;
-      (this.comboBox as any).items = this._getAreas(
+      const areas = this._getAreas(
         Object.values(this.hass.areas),
         Object.values(this.hass.devices),
         Object.values(this.hass.entities),
@@ -273,8 +288,11 @@ export class HaAreaPicker extends LitElement {
         this.includeDeviceClasses,
         this.deviceFilter,
         this.entityFilter,
-        this.noAdd
+        this.noAdd,
+        this.excludeAreas
       );
+      (this.comboBox as any).items = areas;
+      (this.comboBox as any).filteredItems = areas;
     }
   }
 
@@ -384,7 +402,8 @@ export class HaAreaPicker extends LitElement {
             this.includeDeviceClasses,
             this.deviceFilter,
             this.entityFilter,
-            this.noAdd
+            this.noAdd,
+            this.excludeAreas
           );
           await this.updateComplete;
           await this.comboBox.updateComplete;
diff --git a/src/components/ha-target-picker.ts b/src/components/ha-target-picker.ts
index 09336afc65..3aa581b441 100644
--- a/src/components/ha-target-picker.ts
+++ b/src/components/ha-target-picker.ts
@@ -345,6 +345,7 @@ export class HaTargetPicker extends SubscribeMixin(LitElement) {
             .entityFilter=${this.entityRegFilter}
             .includeDeviceClasses=${this.includeDeviceClasses}
             .includeDomains=${this.includeDomains}
+            .excludeAreas=${ensureArray(this.value?.area_id)}
             @value-changed=${this._targetPicked}
           ></ha-area-picker>
         `;
@@ -360,6 +361,7 @@ export class HaTargetPicker extends SubscribeMixin(LitElement) {
             .deviceFilter=${this.deviceFilter}
             .includeDeviceClasses=${this.includeDeviceClasses}
             .includeDomains=${this.includeDomains}
+            .excludeDevices=${ensureArray(this.value?.device_id)}
             @value-changed=${this._targetPicked}
           ></ha-device-picker>
         `;
@@ -375,6 +377,7 @@ export class HaTargetPicker extends SubscribeMixin(LitElement) {
             .entityFilter=${this.entityFilter}
             .includeDeviceClasses=${this.includeDeviceClasses}
             .includeDomains=${this.includeDomains}
+            .excludeEntities=${ensureArray(this.value?.entity_id)}
             @value-changed=${this._targetPicked}
             allow-custom-entity
           ></ha-entity-picker>
@@ -392,6 +395,13 @@ export class HaTargetPicker extends SubscribeMixin(LitElement) {
     const target = ev.currentTarget;
     target.value = "";
     this._addMode = undefined;
+    if (
+      this.value &&
+      this.value[target.type] &&
+      ensureArray(this.value[target.type]).includes(value)
+    ) {
+      return;
+    }
     fireEvent(this, "value-changed", {
       value: this.value
         ? {