diff --git a/gallery/src/pages/misc/integration-card.ts b/gallery/src/pages/misc/integration-card.ts
index e9d74f2f1b..53f16a16b2 100644
--- a/gallery/src/pages/misc/integration-card.ts
+++ b/gallery/src/pages/misc/integration-card.ts
@@ -29,6 +29,7 @@ const createConfigEntry = (
   source: "zeroconf",
   state: "loaded",
   supports_options: false,
+  supports_remove_device: false,
   supports_unload: true,
   disabled_by: null,
   pref_disable_new_entities: false,
diff --git a/src/data/config_entries.ts b/src/data/config_entries.ts
index 78cbe6105a..f2e84ddac0 100644
--- a/src/data/config_entries.ts
+++ b/src/data/config_entries.ts
@@ -13,6 +13,7 @@ export interface ConfigEntry {
     | "not_loaded"
     | "failed_unload";
   supports_options: boolean;
+  supports_remove_device: boolean;
   supports_unload: boolean;
   pref_disable_new_entities: boolean;
   pref_disable_polling: boolean;
diff --git a/src/data/device_registry.ts b/src/data/device_registry.ts
index 65c0bcec56..64e29d3a20 100644
--- a/src/data/device_registry.ts
+++ b/src/data/device_registry.ts
@@ -77,6 +77,17 @@ export const updateDeviceRegistryEntry = (
     ...updates,
   });
 
+export const removeConfigEntryFromDevice = (
+  hass: HomeAssistant,
+  deviceId: string,
+  configEntryId: string
+) =>
+  hass.callWS<DeviceRegistryEntry>({
+    type: "config/device_registry/remove_config_entry",
+    device_id: deviceId,
+    config_entry_id: configEntryId,
+  });
+
 export const fetchDeviceRegistry = (conn) =>
   conn.sendMessagePromise({
     type: "config/device_registry/list",
diff --git a/src/panels/config/devices/ha-config-device-page.ts b/src/panels/config/devices/ha-config-device-page.ts
index b29aa39951..5572834106 100644
--- a/src/panels/config/devices/ha-config-device-page.ts
+++ b/src/panels/config/devices/ha-config-device-page.ts
@@ -27,6 +27,7 @@ import {
   computeDeviceName,
   DeviceRegistryEntry,
   updateDeviceRegistryEntry,
+  removeConfigEntryFromDevice,
 } from "../../../data/device_registry";
 import {
   fetchDiagnosticHandler,
@@ -95,6 +96,8 @@ export class HaConfigDevicePage extends LitElement {
     | number
     | (TemplateResult | string)[];
 
+  @state() private _deleteButtons?: (TemplateResult | string)[];
+
   private _device = memoizeOne(
     (
       deviceId: string,
@@ -186,10 +189,11 @@ export class HaConfigDevicePage extends LitElement {
       changedProps.has("entries")
     ) {
       this._diagnosticDownloadLinks = undefined;
+      this._deleteButtons = undefined;
     }
 
     if (
-      this._diagnosticDownloadLinks ||
+      (this._diagnosticDownloadLinks && this._deleteButtons) ||
       !this.devices ||
       !this.deviceId ||
       !this.entries
@@ -198,7 +202,9 @@ export class HaConfigDevicePage extends LitElement {
     }
 
     this._diagnosticDownloadLinks = Math.random();
+    this._deleteButtons = []; // To prevent re-rendering if no delete buttons
     this._renderDiagnosticButtons(this._diagnosticDownloadLinks);
+    this._renderDeleteButtons();
   }
 
   private async _renderDiagnosticButtons(requestId: number): Promise<void> {
@@ -263,6 +269,55 @@ export class HaConfigDevicePage extends LitElement {
     }
   }
 
+  private _renderDeleteButtons() {
+    const device = this._device(this.deviceId, this.devices);
+
+    if (!device) {
+      return;
+    }
+
+    const buttons: TemplateResult[] = [];
+    this._integrations(device, this.entries).forEach((entry) => {
+      if (entry.state !== "loaded" || !entry.supports_remove_device) {
+        return;
+      }
+      buttons.push(html`
+        <mwc-button
+          class="warning"
+          .entryId=${entry.entry_id}
+          @click=${this._confirmDeleteEntry}
+        >
+          ${buttons.length > 1
+            ? this.hass.localize(
+                `ui.panel.config.devices.delete_device_integration`,
+                {
+                  integration: domainToName(this.hass.localize, entry.domain),
+                }
+              )
+            : this.hass.localize(`ui.panel.config.devices.delete_device`)}
+        </mwc-button>
+      `);
+    });
+
+    if (buttons.length > 0) {
+      this._deleteButtons = buttons;
+    }
+  }
+
+  private async _confirmDeleteEntry(e: MouseEvent): Promise<void> {
+    const entryId = (e.currentTarget as any).entryId;
+
+    const confirmed = await showConfirmationDialog(this, {
+      text: this.hass.localize("ui.panel.config.devices.confirm_delete"),
+    });
+
+    if (!confirmed) {
+      return;
+    }
+
+    await removeConfigEntryFromDevice(this.hass!, this.deviceId, entryId);
+  }
+
   protected firstUpdated(changedProps) {
     super.firstUpdated(changedProps);
     loadDeviceRegistryDetailDialog();
@@ -375,6 +430,9 @@ export class HaConfigDevicePage extends LitElement {
     if (Array.isArray(this._diagnosticDownloadLinks)) {
       deviceActions.push(...this._diagnosticDownloadLinks);
     }
+    if (this._deleteButtons) {
+      deviceActions.push(...this._deleteButtons);
+    }
 
     return html`
       <hass-tabs-subpage
diff --git a/src/translations/en.json b/src/translations/en.json
index 4dc5490f83..36998964a5 100755
--- a/src/translations/en.json
+++ b/src/translations/en.json
@@ -2287,6 +2287,8 @@
           "open_configuration_url_service": "Visit service",
           "download_diagnostics": "Download diagnostics",
           "download_diagnostics_integration": "Download {integration} diagnostics",
+          "delete_device": "Delete device",
+          "delete_device_integration": "Remove {integration} from device",
           "type": {
             "device_heading": "Device",
             "device": "device",