diff --git a/src/components/ha-sidebar.ts b/src/components/ha-sidebar.ts
index fe349178c1..01e84f32ca 100644
--- a/src/components/ha-sidebar.ts
+++ b/src/components/ha-sidebar.ts
@@ -48,6 +48,7 @@ import "./ha-menu-button";
 import "./ha-sortable";
 import "./ha-svg-icon";
 import "./user/ha-user-badge";
+import { preventDefault } from "../common/dom/prevent_default";
 
 const SHOW_AFTER_SPACER = ["config", "developer-tools"];
 
@@ -404,6 +405,7 @@ class HaSidebar extends SubscribeMixin(LitElement) {
         @focusout=${this._listboxFocusOut}
         @scroll=${this._listboxScroll}
         @keydown=${this._listboxKeydown}
+        @iron-activate=${preventDefault}
       >
         ${this.editMode
           ? this._renderPanelsEdit(beforeSpacer)
diff --git a/src/mixins/prevent-unsaved-mixin.ts b/src/mixins/prevent-unsaved-mixin.ts
new file mode 100644
index 0000000000..a1c7b5af92
--- /dev/null
+++ b/src/mixins/prevent-unsaved-mixin.ts
@@ -0,0 +1,57 @@
+import type { LitElement, PropertyValues } from "lit";
+import { isNavigationClick } from "../common/dom/is-navigation-click";
+import type { Constructor } from "../types";
+
+export const PreventUnsavedMixin = <T extends Constructor<LitElement>>(
+  superClass: T
+) =>
+  class extends superClass {
+    private _handleClick = async (e: MouseEvent) => {
+      // get the right target, otherwise the composedPath would return <home-assistant> in the new event
+      const target = e.composedPath()[0];
+      if (!isNavigationClick(e)) {
+        return;
+      }
+
+      const result = await this.promptDiscardChanges();
+      if (result) {
+        this._removeListeners();
+        if (target) {
+          const newEvent = new MouseEvent(e.type, e);
+          target.dispatchEvent(newEvent);
+        }
+      }
+    };
+
+    private _handleUnload = (e: BeforeUnloadEvent) => e.preventDefault();
+
+    private _removeListeners() {
+      window.removeEventListener("click", this._handleClick, true);
+      window.removeEventListener("beforeunload", this._handleUnload);
+    }
+
+    public willUpdate(changedProperties: PropertyValues): void {
+      super.willUpdate(changedProperties);
+
+      if (this.isDirty) {
+        window.addEventListener("click", this._handleClick, true);
+        window.addEventListener("beforeunload", this._handleUnload);
+      } else {
+        this._removeListeners();
+      }
+    }
+
+    public disconnectedCallback(): void {
+      super.disconnectedCallback();
+
+      this._removeListeners();
+    }
+
+    protected get isDirty(): boolean {
+      return false;
+    }
+
+    protected async promptDiscardChanges(): Promise<boolean> {
+      return true;
+    }
+  };
diff --git a/src/panels/config/automation/ha-automation-editor.ts b/src/panels/config/automation/ha-automation-editor.ts
index de9ef7e788..6f0a809257 100644
--- a/src/panels/config/automation/ha-automation-editor.ts
+++ b/src/panels/config/automation/ha-automation-editor.ts
@@ -64,6 +64,7 @@ import { showAutomationModeDialog } from "./automation-mode-dialog/show-dialog-a
 import { showAutomationRenameDialog } from "./automation-rename-dialog/show-dialog-automation-rename";
 import "./blueprint-automation-editor";
 import "./manual-automation-editor";
+import { PreventUnsavedMixin } from "../../../mixins/prevent-unsaved-mixin";
 
 declare global {
   interface HTMLElementTagNameMap {
@@ -82,7 +83,9 @@ declare global {
   }
 }
 
-export class HaAutomationEditor extends KeyboardShortcutMixin(LitElement) {
+export class HaAutomationEditor extends PreventUnsavedMixin(
+  KeyboardShortcutMixin(LitElement)
+) {
   @property({ attribute: false }) public hass!: HomeAssistant;
 
   @property({ attribute: false }) public automationId: string | null = null;
@@ -847,6 +850,14 @@ export class HaAutomationEditor extends KeyboardShortcutMixin(LitElement) {
     };
   }
 
+  protected get isDirty() {
+    return this._dirty;
+  }
+
+  protected async promptDiscardChanges() {
+    return this._confirmUnsavedChanged();
+  }
+
   static get styles(): CSSResultGroup {
     return [
       haStyle,
diff --git a/src/panels/config/scene/ha-scene-editor.ts b/src/panels/config/scene/ha-scene-editor.ts
index ddcb1ca7e8..23eaea4601 100644
--- a/src/panels/config/scene/ha-scene-editor.ts
+++ b/src/panels/config/scene/ha-scene-editor.ts
@@ -77,6 +77,7 @@ import { haStyle } from "../../../resources/styles";
 import type { HomeAssistant, Route } from "../../../types";
 import { showToast } from "../../../util/toast";
 import "../ha-config-section";
+import { PreventUnsavedMixin } from "../../../mixins/prevent-unsaved-mixin";
 
 interface DeviceEntities {
   id: string;
@@ -89,8 +90,8 @@ interface DeviceEntitiesLookup {
 }
 
 @customElement("ha-scene-editor")
-export class HaSceneEditor extends SubscribeMixin(
-  KeyboardShortcutMixin(LitElement)
+export class HaSceneEditor extends PreventUnsavedMixin(
+  SubscribeMixin(KeyboardShortcutMixin(LitElement))
 ) {
   @property({ attribute: false }) public hass!: HomeAssistant;
 
@@ -1225,6 +1226,14 @@ export class HaSceneEditor extends SubscribeMixin(
     });
   }
 
+  protected get isDirty() {
+    return this._dirty;
+  }
+
+  protected async promptDiscardChanges() {
+    return this._confirmUnsavedChanged();
+  }
+
   static get styles(): CSSResultGroup {
     return [
       haStyle,
diff --git a/src/panels/config/script/ha-script-editor.ts b/src/panels/config/script/ha-script-editor.ts
index 0337604713..9e65ec9b33 100644
--- a/src/panels/config/script/ha-script-editor.ts
+++ b/src/panels/config/script/ha-script-editor.ts
@@ -57,8 +57,11 @@ import "./blueprint-script-editor";
 import "./manual-script-editor";
 import type { HaManualScriptEditor } from "./manual-script-editor";
 import { substituteBlueprint } from "../../../data/blueprint";
+import { PreventUnsavedMixin } from "../../../mixins/prevent-unsaved-mixin";
 
-export class HaScriptEditor extends KeyboardShortcutMixin(LitElement) {
+export class HaScriptEditor extends PreventUnsavedMixin(
+  KeyboardShortcutMixin(LitElement)
+) {
   @property({ attribute: false }) public hass!: HomeAssistant;
 
   @property({ attribute: false }) public scriptId: string | null = null;
@@ -813,6 +816,14 @@ export class HaScriptEditor extends KeyboardShortcutMixin(LitElement) {
     };
   }
 
+  protected get isDirty() {
+    return this._dirty;
+  }
+
+  protected async promptDiscardChanges() {
+    return this._confirmUnsavedChanged();
+  }
+
   static get styles(): CSSResultGroup {
     return [
       haStyle,