diff --git a/package/samba4/Config.in b/package/samba4/Config.in
index ba48b8ab37..298fdc6608 100644
--- a/package/samba4/Config.in
+++ b/package/samba4/Config.in
@@ -1,6 +1,6 @@
-comment "samba4 needs a toolchain w/ RPC, wchar, dynamic library, NPTL"
+comment "samba4 needs a uClibc or glibc toolchain w/ wchar, dynamic library, NPTL"
 	depends on BR2_TOOLCHAIN_HAS_SYNC_4
-	depends on !BR2_USE_WCHAR || !BR2_TOOLCHAIN_HAS_NATIVE_RPC \
+	depends on !BR2_USE_WCHAR || BR2_TOOLCHAIN_USES_MUSL \
 		|| BR2_STATIC_LIBS || !BR2_TOOLCHAIN_HAS_THREADS_NPTL
 	depends on BR2_USE_MMU
 
@@ -8,12 +8,13 @@ config BR2_PACKAGE_SAMBA4
 	bool "samba4"
 	depends on BR2_USE_MMU # fork()
 	depends on BR2_USE_WCHAR # python
-	depends on BR2_TOOLCHAIN_HAS_NATIVE_RPC
 	depends on BR2_TOOLCHAIN_HAS_THREADS_NPTL # python -> libffi
 	depends on !BR2_STATIC_LIBS # python, gnutls
 	depends on !BR2_nios2 # binary too large, relocations don't fit
 	depends on BR2_TOOLCHAIN_HAS_SYNC_4
+	depends on !BR2_TOOLCHAIN_USES_MUSL
 	select BR2_PACKAGE_E2FSPROGS
+	select BR2_PACKAGE_LIBTIRPC if !BR2_TOOLCHAIN_HAS_NATIVE_RPC
 	select BR2_PACKAGE_POPT
 	select BR2_PACKAGE_PYTHON
 	select BR2_PACKAGE_ZLIB
diff --git a/package/samba4/samba4.mk b/package/samba4/samba4.mk
index 72fbd7448f..ffa101b73f 100644
--- a/package/samba4/samba4.mk
+++ b/package/samba4/samba4.mk
@@ -17,6 +17,17 @@ SAMBA4_DEPENDENCIES = \
 	$(if $(BR2_PACKAGE_LIBCAP),libcap) \
 	$(if $(BR2_PACKAGE_READLINE),readline) \
 	$(TARGET_NLS_DEPENDENCIES)
+SAMBA4_CFLAGS = $(TARGET_CFLAGS)
+SAMBA4_LDFLAGS = $(TARGET_LDFLAGS)
+SAMBA4_CONF_ENV = \
+	CFLAGS="$(SAMBA4_CFLAGS)" \
+	LDFLAGS="$(SAMBA4_LDFLAGS)"
+
+ifeq ($(BR2_PACKAGE_LIBTIRPC),y)
+SAMBA4_CFLAGS += `$(PKG_CONFIG_HOST_BINARY) --cflags libtirpc`
+SAMBA4_LDFLAGS += `$(PKG_CONFIG_HOST_BINARY) --libs libtirpc`
+SAMBA4_DEPENDENCIES += libtirpc host-pkgconf
+endif
 
 ifeq ($(BR2_PACKAGE_ACL),y)
 SAMBA4_CONF_OPTS += --with-acl-support