diff --git a/package/valgrind/Config.in b/package/valgrind/Config.in
index 56e4af21fa..8fe7080cd7 100644
--- a/package/valgrind/Config.in
+++ b/package/valgrind/Config.in
@@ -2,7 +2,10 @@ config BR2_PACKAGE_VALGRIND_ARCH_SUPPORTS
 	bool
 	default y if BR2_aarch64
 	default y if BR2_ARM_CPU_ARMV7A
-	default y if BR2_mips || BR2_mipsel || BR2_mips64 || BR2_mips64el
+	default y if BR2_mips || BR2_mipsel
+	# MIPS64 R6 is unsupported
+	default y if BR2_mips64 && !BR2_mips_64r6
+	default y if BR2_mips64el && !BR2_mips_64r6
 	default y if BR2_i386 || BR2_x86_64
 	default y if BR2_powerpc || BR2_powerpc64 || BR2_powerpc64le
 	depends on !BR2_MIPS_SOFT_FLOAT